Abstract:
:The influence of estrogen therapy on changes in arthritis and bone mineral density (BMD) was evaluated using an estrogen-replete collagen-induced arthritis (CIA) rat model. Seven-month-old female Sprague-Dawley rats (n = 30) were divided into the three groups; control (CONT), collagen sensitization (CIA), and CIA + 17beta-estradiol administration for 7 weeks (CIA + E). BMD was measured by peripheral quantitative computed tomography in the proximal tibia every 2 weeks. Eight weeks after the initial sensitization the rats were killed and histomorphometry of tibia was performed. The hind paw thickness increased with time in CIA rats and there was a significant difference between CONT and CIA at 8 weeks after the initial sensitization. Estrogen tended to make the development of arthritis milder. In CIA, BMD at metaphyseal cancellous bone began to decrease with the onset of arthritis and became significantly lower than in CONT after 8 weeks. Compared with the CIA, the deterioration in BMD was inhibited in CIA + E. Histomorphometrical parameters of bone resorption were increased in CIA compared with CONT, and those elevations were reduced by estrogen treatment, but estrogen had no effect on bone formation parameters. In conclusion, estrogen could partially suppress arthritis and bone loss in estrogen-replete rats as well as estrogen-deplete ones.
journal_name
Mod Rheumatoljournal_title
Modern rheumatologyauthors
Yoshioka T,Hagino H,Yamasaki D,Okano T,Teshima Rdoi
10.1007/s10165-007-0011-2subject
Has Abstractpub_date
2008-01-01 00:00:00pages
23-8issue
1eissn
1439-7595issn
1439-7609journal_volume
18pub_type
杂志文章abstract:OBJECTIVES:This pilot multicenter exercise aimed to evaluate the inter-observer reproducibility of synovial power Doppler (PD) signals in rheumatoid arthritis (RA) patients and to determine the factors influencing the measurements. METHODS:Two representative RA patients were assessed by four independent experienced so...
journal_title:Modern rheumatology
pub_type: 杂志文章,多中心研究
doi:10.3109/14397595.2013.843763
更新日期:2014-05-01 00:00:00
abstract:INTRODUCTION:Assessment of synovitis in the metatarsophalangeal (MTP) joints with ultrasound has been shown to improve the accuracy of assessment of rheumatoid arthritis (RA). However, the presence of intraarticular low-echoic synovial area (LESA) in the MTP joints in healthy subjects complicates the sonographic assess...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2014.970740
更新日期:2015-05-01 00:00:00
abstract:OBJECTIVE:This study aimed to evaluate whether the level of serum matrix metalloproteinase-3 (MMP-3), a marker of synovium inflammation, is affected by clinical characteristics of patients in rheumatoid arthritis (RA) patients. METHODS:We analyzed data from 1087 female patients with RA. Pearson's correlation coefficie...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2017.1354431
更新日期:2018-03-01 00:00:00
abstract::A 68-year-old Japanese male presented with atrophic erythematous white lesions with peripheral dark reddish rims on his back. Multiple ulcers were detected from his stomach to his large intestine using endoscopy. Although the patient was given high doses of a steroid, aspirin, dipyridamole, and intravenous immunoglobu...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2013.874761
更新日期:2015-05-01 00:00:00
abstract::Objective: This study aimed to clarify whether plasma acrolein level actually increases in rheumatoid arthritis (RA) patients, and to elucidate whether any relationship exists between the levels and the RA background variables.Methods: Plasma levels of protein-conjugated acrolein (PC-Acro) in 84 patients (RA group) an...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2020.1775921
更新日期:2020-06-16 00:00:00
abstract::The purpose of this study was to describe the prevalence of total joint arthroplasty (TJA) in Japanese rheumatoid arthritis (RA) patients undergoing conventional drug treatment in a large observational cohort in Japan. A total of 5,177 RA patients were studied for the prevalence of TJA, who were enrolled in the NinJa ...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-009-0163-3
更新日期:2009-01-01 00:00:00
abstract::Abstract The synovium in a knee joint has an extensive neural network in the somatic and autonomic nervous systems. In medial compartmental osteoarthritis of the knee, neuropeptides were most abundant, with an especially large number of substance P and calcitonin gene-related peptide-immunoreactive free nerve endings....
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/s10165-003-0253-6
更新日期:2003-12-01 00:00:00
abstract::Peripheral neuropathies should be recognized as the adverse effects of biological agents, especially anti-TNF agents. However, no solid clinical databases for biological agent-associated peripheral neuropathies (BAPN) have been established in Japan. Here we report two cases of peripheral neuropathy associated with ant...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2013.859770
更新日期:2016-01-01 00:00:00
abstract::The current study investigates the role of regulatory T (Treg) cells in the pathogenesis of ocular attack in patients with Behcet's disease (BD). Nineteen BD patients with ocular complications (BDo), including 11 BD patients with ocular attack (BDa) and eight BD patients with inactive ocular complications (BDi), were ...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-008-0064-x
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVES:Cryopyrin-associated periodic syndrome (CAPS) is caused by unrestricted IL-1β release due to mutation of the gene coding NLRP3. This study aimed to clarify whether NLRP3-related IL-1β release is dependent on the NF-κB pathway. METHODS:Peripheral blood mononuclear cells (PBMCs) from healthy subjects or patie...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2013.844298
更新日期:2014-05-01 00:00:00
abstract::We aimed to retrospectively review the incidence of pre-diabetes mellitus (preDM), one of the factors in metabolic syndrome screening, in patients with rheumatic diseases. We examined the levels of hemoglobin A1c (HbA1c) in a total of 498 patients with rheumatic diseases between April 2007 and March 2008 at the Depart...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-011-0433-8
更新日期:2011-10-01 00:00:00
abstract::Abstract An accumulating body of evidence shows that gene therapy can be successfully used to treat animal models of arthritis. Based on this success, a clinical trial of gene therapy for rheumatoid arthritis has been initiated. We review the methods and genes used for the previous gene transfer experiments, including...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/s101650050003
更新日期:2000-06-01 00:00:00
abstract::The association of either thrombotic thrombocytopenic purpura (TTP) or crescentic glomerulonephritis with Sjögren's syndrome is rare. We report a case of TTP appearing after the diagnosis of SjOgren's syndrome with crescentic glomerulonephritis and membranous nephropathy. Circulating immune complex was detected, and i...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-004-0287-4
更新日期:2004-01-01 00:00:00
abstract:INTRODUCTION:We aimed to identify causes of false-positives in ultrasound scanning of synovial/tenosynovial/bursal inflammation and provide corresponding imaging examples. METHODS:We first performed systematic literature review to identify previously reported causes of false-positives. We next determined causes of fal...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2015.1091123
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVES:To evaluate the long-term efficacy and safety of certolizumab pegol (CZP) plus methotrexate treatment and to assess the efficacy of two CZP maintenance dosing schedules in Japanese rheumatoid arthritis (RA) patients with an inadequate response to methotrexate. METHODS:J-RAPID double-blind patients were ente...
journal_title:Modern rheumatology
pub_type: 杂志文章,随机对照试验
doi:10.3109/14397595.2014.881709
更新日期:2014-09-01 00:00:00
abstract::A 24-year-old Japanese woman was admitted to our hospital suffering from high fever and progressive paralysis in both legs. Magnetic resonance imaging of the spinal cord showed high-intensity signals from C5 to Th4 and from Th7 to L1 on T2-weighted images. The patient was diagnosed as having acute transverse myelitis ...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-004-0376-4
更新日期:2005-01-01 00:00:00
abstract::Anti-tumor necrosis factor (anti-TNF) biologics are effective in the treatment of rheumatoid arthritis (RA); however, it is still not clear whether this treatment promotes the development of malignancies such as lymphoma. Human T-lymphotropic virus type 1 (HTLV-1), which is a causative agent of adult T-cell lymphoma (...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2013.844389
更新日期:2015-09-01 00:00:00
abstract::We evaluated the utility of HEp-2 cells transfected with the 60 kDa SS-A/Ro as a substrate for indirect immunofluorescence (IIF-HEp-2000) to compare several methods for screening Japanese serum samples for anti-SS-A/Ro antibodies. Serum samples from 243 Japanese patients were analyzed by IIF for anti-nuclear antibodie...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-008-0100-x
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVES:The characteristics of lymphoproliferative disorders (LPD) in patients with rheumatoid arthritis (RA) remain unclear. Therefore, we retrospectively analyzed the clinical characteristics of these patients in our department. METHODS:Twenty RA patients who developed LPD between April 2003 and August 2016 in ou...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2017.1387223
更新日期:2018-07-01 00:00:00
abstract::Objectives: Delayed wound healing is one of the most common complications following forefoot surgery in patients with rheumatoid arthritis. We aimed to identify the risk factors for delayed wound healing following rheumatoid forefoot surgery.Methods: Consecutive patients who underwent primary rheumatoid forefoot surge...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2020.1775960
更新日期:2020-06-16 00:00:00
abstract:OBJECTIVES:In this study, we aimed to assess the effect of combination of proliferative and membranous lesions (Class III + V or IV + V) on renal outcomes as an independent category distinct from Class III and IV. METHODS:We retrospectively analyzed 103 Japanese patients (14 male and 89 female) with Class III/IV LN, w...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2016.1158896
更新日期:2016-11-01 00:00:00
abstract::Objectives: To assess the clinicopathologic features of Multicentric Castleman disease (MCD) patients in Japan.Methods: We assessed baseline data for 342 Japanese MCD patients with a biopsy-proven diagnosis, enrolled in a prospective, observational study for tocilizumab treatment.Results: Of 342 patients, 86.0% had pl...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2019.1704983
更新日期:2020-09-01 00:00:00
abstract::Abstract A 56-year-old man presented with hyperproteinemia and renal dysfunction associated with antineutrophil cytoplasmic antibodies (ANCA). He had had a ventriculoperitoneal shunt tube made of silicone implanted 4 years earlier. In his renal biopsy, necrotizing crescentic glomerulonephritis was identified: tests fo...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/s101650300011
更新日期:2003-03-01 00:00:00
abstract:OBJECTIVES:To evaluate joint inflammation using 3-T MRI in rheumatoid arthritis (RA) patients treated with conventional disease modifying anti-rheumatic drugs (cDMARDs) as compared to inhibitors for tumor necrosis factor α (TNFi) over 12 months. METHODS:Prospective epidemiologic clinical pilot study using the RA MRI s...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2018.1467525
更新日期:2019-05-01 00:00:00
abstract::Research into the bone destruction associated with rheumatoid arthritis has highlighted the importance of the interplay of the immune and skeletal systems. Arthritic bone destruction is attributable to the defective control of osteoclastogenesis by T cells. We revealed that excessive expression of receptor activator o...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-005-0398-6
更新日期:2005-01-01 00:00:00
abstract::Abstract We investigated the role of nuclear factor (NF)-κB on tumor necrosis factor (TNF)-α-induced regulated upon activation, normal T-cell expressed and secreted (RANTES) expression in fibroblast-like synoviocytes from patients with rheumatoid arthritis (RA). Using cultured human fibroblast-like synoviocytes from p...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/s101650200006
更新日期:2002-03-01 00:00:00
abstract::Here, we report the case of a 69-year-old man with limited granulomatosis with polyangiitis (GPA; formerly Wegener's granulomatosis) who developed papillary thyroid cancer, adenocarcinoma of the stomach, and myelodysplastic syndrome following glucocorticoid treatment. This is the first report to present multiple malig...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2014.891494
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:Neutrophil extracellular traps (NETs) are peculiar structures composed of the externalized chromatin with intracellular proteins and formed by activated neutrophils in a reactive oxygen species (ROS)-dependent manner. Aberrant NETs are considered to be autoantigens for anti-neutrophil cytoplasmic antibodies (...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2017.1367116
更新日期:2018-05-01 00:00:00
abstract:OBJECTIVES:The aim of our study is to clarify the association of myositis-specific autoantibodies (MSAs) with clinical and laboratory features in Japanese patients with juvenile idiopathic inflammatory myopathies (JIIMs). METHODS:We retrospectively analyzed the frequency of MSAs and their association with clinical or ...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2018.1452353
更新日期:2019-03-01 00:00:00
abstract::The development of multiple large tophi in patients with gout is rare. We report magnetic resonance (MR) and histological features of large subcutaneous tophi in a 32-year-old male patient with no known arthritis. His subcutaneous lesions were confused with a neoplastic process, evaluated by MR imaging, and surgically...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-005-0401-2
更新日期:2005-01-01 00:00:00