Abstract:
OBJECTIVES:To evaluate joint inflammation using 3-T MRI in rheumatoid arthritis (RA) patients treated with conventional disease modifying anti-rheumatic drugs (cDMARDs) as compared to inhibitors for tumor necrosis factor α (TNFi) over 12 months. METHODS:Prospective epidemiologic clinical pilot study using the RA MRI system (RAMRIS), the visual analog scale (VAS, 0-100) and the Disease Activity Score 28-joint count (DAS28) at baseline, 4, and 12 months after initiation of etanercept (ETA). Ten patients with inadequate response to two cDMARDs were treated with ETA and compared to 10 patients responding to cDMARDs. RESULTS:In cDMARD patients, parameters at baseline and 12 months did not change: VAS: 21.0 ± 11.3 and 20.2 ± 24.6; DAS28: 2.1 ± 0.6 and 2.9 ± 1.0; and RAMRIS: 11.0 ± 2.3 and 11.8 ± 2.8, respectively. In contrast, in the ETA-patients the same parameters were as follows at baseline, 4, and 12 months: VAS: 46.3 ± 7.9, 23.9 ± 7.1, and 24.0 ± 6.3 (each p = .04); DAS28: 3.8 ± 0.4, 2.8 ± 0.3 (ns), and 2.5 ± 0.3 (p = .01); and RAMRIS: 28.9 ± 5.0, 25.8 ± 4.7 (ns), and 24.6 ± 4.5 (ns). Comparing ETA and cDMARD patients, RAMRIS was significantly different. CONCLUSION:The data suggest that synovial inflammation and DAS28 remission are separate entities in RA. MRI scoring before starting a treatment may therefore indicate the requirement for TNFi.
journal_name
Mod Rheumatoljournal_title
Modern rheumatologyauthors
Oleszowsky M,Willinek W,Marinova M,Seidel MFdoi
10.1080/14397595.2018.1467525subject
Has Abstractpub_date
2019-05-01 00:00:00pages
441-446issue
3eissn
1439-7595issn
1439-7609journal_volume
29pub_type
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journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/s10165-001-8066-y
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journal_title:Modern rheumatology
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journal_title:Modern rheumatology
pub_type: 杂志文章,meta分析,评审
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pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:Modern rheumatology
pub_type: 临床试验,杂志文章
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journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2013.879416
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pub_type: 杂志文章
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