Anti-SS-A/Ro antibody determination by indirect immunofluorescence and comparison of different methods of anti-nuclear antibody screening: evaluation of the utility of HEp-2 cells transfected with the 60 kDa SS-A/Ro as a substrate.

abstract：OBJECTIVES:To evaluate the therapeutic efficacy of a novel inhibitor for IκB kinase alpha (IKKα), noraristeromycin (NAM), for murine experimental model of rheumatoid arthritis, collagen- induced arthritis (CIA). METHODS:NAM has been chemically synthesized as reported earlier. CIA was induced in DBA/1JNCrlj mice by int...

journal_title：Modern rheumatology

authors： Ito M,Hamano T,Komatsu T,Asamitsu K,Yamakawa T,Okamoto T

更新日期：2014-09-01 00:00:00

abstract：:The most representative kidney lesion of IgG4-related disease (IgG4-RD) is plasma cell-rich tubulointerstitial nephritis (TIN) with distinctive imaging findings including multiple low-density lesions on contrast-enhanced computed tomography. In addition, membranous glomerulonephritis is a representative glomerular les...

journal_title：Modern rheumatology

authors： Kawano M,Saeki T,Nakashima H

更新日期：2019-03-01 00:00:00

abstract：:A 68-year-old man with a fever of unknown origin was admitted to our hospital. Bilateral auricularis and nasal root inflammation, with auricular perichondritis positive for anti-type II collagen (CII) antibody, led to a diagnosis of relapsing polychondritis (RP). Because the patient was refractory for high-dose glucoc...

journal_title：Modern rheumatology

authors： Nakamura H,Suzuki T,Nagaoka K,Yamasaki S,Tamai M,Hayashi T,Kawakami A

更新日期：2011-12-01 00:00:00

abstract：OBJECTIVE:Evaluate the association between the multi-biomarker disease activity (MBDA) score and radiographic progression in patients with rheumatoid arthritis (RA) treated with tumor necrosis factor (TNF)-α inhibitors. METHODS:Change (Δ) in modified total Sharp score (mTSS) over 52 weeks and disease activity scores w...

journal_title：Modern rheumatology

authors： Hirata S,Li W,Kubo S,Fukuyo S,Mizuno Y,Hanami K,Sawamukai N,Yamaoka K,Saito K,Defranoux NA,Tanaka Y

更新日期：2016-11-01 00:00:00

abstract：:A 43-year-old Japanese woman with systemic lupus erythematosus (SLE) developed rapidly progressive renal failure and nephritic syndrome with a high titer of myeloperoxidase-antineutrophil cytoplasmic antibody (MPO-ANCA). Methylprednisolone pulse therapy did not suppress the progression of renal failure. Intravenous cy...

journal_title：Modern rheumatology

authors： Morimoto S,Watanabe T,Lee S,Amano H,Kanamaru Y,Ohsawa I,Tomino Y,Takasaki Y

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:Colchicine is the mainstay of the treatment of familial Mediterranean fever (FMF). However, 10% of FMF patients do not respond well to colchicine. Efficacy of interleukin (IL)-1 inhibitors in reducing attacks have been demonstrated in colchicine-resistant FMF (crFMF) patients recently. Colchicine is still th...

journal_title：Modern rheumatology

authors： Varan Ö,Kucuk H,Babaoglu H,Guven SC,Ozturk MA,Haznedaroglu S,Goker B,Tufan A

更新日期：2019-03-01 00:00:00

abstract：:The influence of estrogen therapy on changes in arthritis and bone mineral density (BMD) was evaluated using an estrogen-replete collagen-induced arthritis (CIA) rat model. Seven-month-old female Sprague-Dawley rats (n = 30) were divided into the three groups; control (CONT), collagen sensitization (CIA), and CIA + 17...

journal_title：Modern rheumatology

authors： Yoshioka T,Hagino H,Yamasaki D,Okano T,Teshima R

更新日期：2008-01-01 00:00:00

abstract：:Abstract A 17-year-old woman who was being treated with prednisolone for cutaneous vasculitis developed recurrent massive melena and abdominal pain. An emergency resection was performed because of uncontrollable melena, revealing many small intestinal ulcers with cytomegalic inclusion bodies, which were found by immun...

journal_title：Modern rheumatology

authors： Ota Y,Ohashi H,Otani C,Dei Y,Kondo S,Baba S

更新日期：2002-09-01 00:00:00

abstract：OBJECTIVES:The objective of this study is to evaluate the efficacy and safety of long-term (64 weeks; 52-week extension of a 12-week study) baricitinib treatment in Japanese patients with active rheumatoid arthritis (RA) despite methotrexate therapy. METHODS:Patients (N = 145) with active RA were randomized to placebo...

journal_title：Modern rheumatology

authors： Tanaka Y,Ishii T,Cai Z,Schlichting D,Rooney T,Macias W

更新日期：2018-01-01 00:00:00

abstract：:A 49-year-old Japanese woman treated with oral corticosteroids, methotrexate, and infliximab for malignant rheumatoid arthritis was admitted because of fever and low back pain. The white blood cell count and C-reactive protein concentration were elevated. Lumbar and pelvic computed tomography showed enlargement of the...

journal_title：Modern rheumatology

authors： Oda S,Fujinaga H,Takahashi K

更新日期：2006-01-01 00:00:00

abstract：:Bucillamine (Bc) is a cysteine derivative with two SH groups, and a homolog of D-penicillamine, a disease-modifying antirheumatic drug (DMARD) widely used in Japan. However, it remains unclear whether Bc repairs bone erosion in patients with RA. Here, we treated three RA patients with Bc who subsequently showed radiog...

journal_title：Modern rheumatology

authors： Nanke Y,Iwatani M,Kobashigawa T,Yago T,Yamanaka H,Kotake S

更新日期：2009-01-01 00:00:00

abstract：:Macrophage activation syndrome (MAS), also known as secondary hemophagocytic lymphohistiocytosis, is mediated by cytokine overproduction from excessive activation of T lymphocytes and macrophages. We present a dermatomyositis patient with MAS, caused by hypercytokinemia. The combination of tacrolimus and plasma exchan...

journal_title：Modern rheumatology

authors： Kaieda S,Yoshida N,Yamashita F,Okamoto M,Ida H,Hoshino T,Fukuda T

更新日期：2015-01-01 00:00:00

abstract：:We evaluated the prevalence of Helicobacter pylori infection and the association of H. pylori infection and/or nonsteroidal anti-inflammatory drug (NSAID) use with upper gastrointestinal (UGI) ulcers in a cohort of Japanese patients with rheumatoid arthritis (RA). Using the clinical database of the cohort of RA patien...

journal_title：Modern rheumatology

authors： Tanaka E,Singh G,Saito A,Syouji A,Yamada T,Urano W,Nakajima A,Taniguchi A,Tomatsu T,Hara M,Saito T,Kamatani N,Yamanaka H

更新日期：2005-01-01 00:00:00

abstract：:One of the severe adverse effects of intra-articular injection in the knee is septic arthritis of the knee joint. Staphylococcus aureus is the most frequent pathogen of septic arthritis. Staphylococcal scalded skin syndrome (SSSS) refers to a spectrum of blistering skin diseases caused by S. aureus exfoliative toxins....

journal_title：Modern rheumatology

authors： Kunugiza Y,Tani M,Tomita T,Yoshikawa H

更新日期：2011-06-01 00:00:00

abstract：OBJECTIVE:To investigate which IgG subclasses contribute to the activation of the complement pathway in IgG4-related disease (IgG4RD) patients with hypocomplementemia. METHODS:Sera of IgG4RD patients were analyzed for the binding ability of IgG subclasses to complement component 1q (C1q). Polyethylene glycol (PEG) pre...

journal_title：Modern rheumatology

authors： Sugimoto M,Watanabe H,Asano T,Sato S,Takagi T,Kobayashi H,Ohira H

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVES:The aim of our study is to clarify the association of myositis-specific autoantibodies (MSAs) with clinical and laboratory features in Japanese patients with juvenile idiopathic inflammatory myopathies (JIIMs). METHODS:We retrospectively analyzed the frequency of MSAs and their association with clinical or ...

journal_title：Modern rheumatology

authors： Ueki M,Kobayashi I,Takezaki S,Tozawa Y,Okura Y,Yamada M,Kuwana M,Ariga T

更新日期：2019-03-01 00:00:00

abstract：:Abstract Twenty-six patients with systemic lupus erythematosus (SLE) showing systemic lupus activity measure (SLAM) and SLE disease activity index (SLEDAI) scores ≤2, as well as a lower C4 concentration than the mean C4 levels of healthy controls, were selected to evaluate the C4 levels of SLE patients in remission. S...

journal_title：Modern rheumatology

authors： Yasuda M,Suenaga Y,Nishimukai H,Nobunaga M

更新日期：2002-09-01 00:00:00

abstract：OBJECTIVES:To assess the efficacy of tocilizumab for preventing damage to the joints of systemic juvenile idiopathic arthritis (sJIA) patients, we examined serial radiographs of the hands and large weight-bearing joints of these patients before and after treatment with this agent. METHODS:Nine patients with sJIA recei...

journal_title：Modern rheumatology

authors： Inaba Y,Ozawa R,Aoki C,Imagawa T,Mori M,Hara R,Miyamae T,Saito T,Yokota S

更新日期：2013-07-01 00:00:00

abstract：OBJECTIVES:We investigated the characteristics of circulating T-helper (Th) cells and CD4+ regulatory T cells (Tregs) in polyarteritis nodosa (PAN). METHODS:Peripheral blood samples were obtained from 14 patients with PAN. Nine patients having granulomatosis with polyangiitis (GPA) and 11 healthy individuals (HC) were...

journal_title：Modern rheumatology

authors： Shimojima Y,Ishii W,Kishida D,Fukushima K,Ikeda SI

更新日期：2017-01-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is a complex process of chronic and progressive inflammation associated with activation of numerous signaling molecules and transcription factors and hyperproliferation of synoviocytes of the affected joints, although the greater part of its pathophysiological process is explained by activati...

journal_title：Modern rheumatology

authors： Okamoto T

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVES:To assess changes in salivary epidermal growth factor (EGF) levels within three years and investigate the correlation between these changes and the severity of intraoral manifestations in patients with Sjögren's syndrome (SS). METHODS:Twenty-three SS patients (14 primary SS and 9 secondary SS) and 14 contro...

journal_title：Modern rheumatology

authors： Azuma N,Katada Y,Kitano S,Sekiguchi M,Kitano M,Nishioka A,Hashimoto N,Matsui K,Iwasaki T,Sano H

更新日期：2015-01-01 00:00:00

abstract：:Aortitis, inflammation of the aortic tissue, is most commonly caused by vasculitic rheumatic conditions, and less frequently infectious organisms. Involvement of the aorta is well defined in HLA-B27-associated spondyloarthropathies such as long-standing ankylosing spondylitis and Reiter's syndrome. However, unlike oth...

journal_title：Modern rheumatology

authors： Tufan A,Engin Tezcan M,Kaya A,Mercan R,Oner Y,Ozturk MA

更新日期：2012-09-01 00:00:00

abstract：:We investigated the clinical efficacy and safety of tocilizumab (a humanized anti-IL-6 receptor antibody) monotherapy in active rheumatoid arthritis (RA) patients with an inadequate response to low dose methotrexate (MTX). In a multicenter, double-blind, randomized, controlled trial, 125 patients were allocated to rec...

journal_title：Modern rheumatology

authors： Nishimoto N,Miyasaka N,Yamamoto K,Kawai S,Takeuchi T,Azuma J,Kishimoto T

更新日期：2009-01-01 00:00:00

abstract：OBJECTIVE:To evaluate the safety of peficitinib for the treatment of rheumatoid arthritis (RA) in Asian patients. METHODS:Safety data from one Phase 2b, two Phase 3, and one open-label long-term extension study [data cut-off 31 May 2018] were pooled into Phase 3 studies (peficitinib 100 and 150 mg/day, and placebo) an...

journal_title：Modern rheumatology

authors： Takeuchi T,Tanaka Y,Rokuda M,Izutsu H,Kaneko Y,Fukuda M,Kato D

更新日期：2020-11-09 00:00:00

abstract：OBJECTIVES:To establish a new assessment tool for ulnar drift (UD) in rheumatoid arthritis (RA). METHODS:We established an observational cohort of 67 patients (134 rheumatoid hands) beginning in 2004. Fifty-two patients (100 hands) had follow-up in 2009 and 37 patients (63 hands) completed follow-up in 2015. UD was ev...

journal_title：Modern rheumatology

authors： Toyama S,Oda R,Tokunaga D,Taniguchi D,Nakamura S,Asada M,Fujiwara H,Kubo T

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVES:We investigated the association between hand dysfunction and ultrasound (US)-detected articular synovitis and tenosynovitis in patients with rheumatoid arthritis (RA). METHODS:Thirty RA patients were examined. In both hands of all subjects, articular synovitis and tenosynovitis were assessed by US at 22 joi...

journal_title：Modern rheumatology

authors： Nishino A,Kawashiri SY,Shimizu T,Umeda M,Fukui S,Koga T,Iwamoto N,Ichinose K,Tamai M,Nakamura H,Origuchi T,Nagata Y,Maeda T,Aoyagi K,Kawakami A

更新日期：2017-07-01 00:00:00

abstract：OBJECTIVES:The objective of this study is to clarify the surgical indication for rheumatoid forefoot deformity according to background characteristics and plantar pressure. METHODS:Patients with rheumatoid arthritis were divided into a non-surgical group (group N) and a surgical group (group S). The former consisted o...

journal_title：Modern rheumatology

authors： Lee H,Ishikawa H,Miyagawa Y,Takai C,Nomura Y,Nemoto T,Kobayashi D,Abe A,Otani H,Ito S,Nakazono K,Ishii T,Saito S,Tokuhashi Y,Murasawa A

更新日期：2017-11-01 00:00:00

abstract：:Tocilizumab (TCZ) is an interleukin-6 (IL-6) inhibitor used for the treatment of rheumatoid arthritis (RA). It was developed in 2008, and its effectiveness is supported by evidence from all over the world based on its first decade of use. Although the overall efficacy and safety profiles of TCZ are similar to those of...

journal_title：Modern rheumatology

authors： Ogata A,Kato Y,Higa S,Yoshizaki K

更新日期：2019-03-01 00:00:00

abstract：OBJECTIVES:To evaluate the long-term efficacy and safety of certolizumab pegol (CZP) plus methotrexate treatment and to assess the efficacy of two CZP maintenance dosing schedules in Japanese rheumatoid arthritis (RA) patients with an inadequate response to methotrexate. METHODS:J-RAPID double-blind patients were ente...

journal_title：Modern rheumatology

authors： Tanaka Y,Yamamoto K,Takeuchi T,Yamanaka H,Ishiguro N,Eguchi K,Watanabe A,Origasa H,Shoji T,Miyasaka N,Koike T

更新日期：2014-09-01 00:00:00

abstract：OBJECTIVES:To develop and evaluate an exercise program that the elderly could sustainably perform in the community or at home to recover from locomotive syndrome. METHODS:We produced 2 types of teaching media, video and pamphlet, describing 10 physical and mobility training exercises. The pilot study examined changes ...

journal_title：Modern rheumatology

authors： Hashizume H,Yoshimura N,Nagata K,Miyazaki N,Ishimoto Y,Nishiyama R,Oka H,Yamada H,Yoshida M

更新日期：2014-03-01 00:00:00