Possible participation of IgG4 in the activation of complement in IgG4-related disease with hypocomplementemia.

abstract：:Methotrexate (MTX) is indispensable for the treatment of rheumatoid arthritis (RA). However, a small number of patients treated with MTX occasionally encounter some life-threatening events, including myelosuppression. Renal insufficiency, one of risk factors for these events, is difficult to assess because the serum c...

journal_title：Modern rheumatology

authors： Hayashi T,Ito S,Goto D,Matsumoto I,Sumida T

更新日期：2010-12-01 00:00:00

abstract：OBJECTIVES:We investigated the association between hand dysfunction and ultrasound (US)-detected articular synovitis and tenosynovitis in patients with rheumatoid arthritis (RA). METHODS:Thirty RA patients were examined. In both hands of all subjects, articular synovitis and tenosynovitis were assessed by US at 22 joi...

journal_title：Modern rheumatology

authors： Nishino A,Kawashiri SY,Shimizu T,Umeda M,Fukui S,Koga T,Iwamoto N,Ichinose K,Tamai M,Nakamura H,Origuchi T,Nagata Y,Maeda T,Aoyagi K,Kawakami A

更新日期：2017-07-01 00:00:00

abstract：OBJECTIVES:A self-administered foot evaluation questionnaire (SAFE-Q) was developed by the Japanese Society for Surgery of the Foot (JSSF). The aim of this study is to evaluate the validity and responsiveness of the SAFE-Q in patients with rheumatoid arthritis (RA). METHODS:In total, 180 patients with RA answered the ...

journal_title：Modern rheumatology

authors： Yano K,Ikari K,Ochi K,Ishida O,Sakuma Y,Yoshida S,Koyama T,Koenuma N,Momohara S

更新日期：2015-05-01 00:00:00

abstract：:Abstract Little is known about the specific effects of the ultra-high molecular weight polyethylene (UHMWP) debris that is obtained from human interface membranes after revision for a failed total hip arthroplasty. This paper reports the effects of retrieved polyethylene particles on human monocyte/macrophages (M/M). ...

journal_title：Modern rheumatology

authors： Chiba J,Inoue K

更新日期：2000-03-01 00:00:00

abstract：:Objectives: To assess the clinicopathologic features of Multicentric Castleman disease (MCD) patients in Japan.Methods: We assessed baseline data for 342 Japanese MCD patients with a biopsy-proven diagnosis, enrolled in a prospective, observational study for tocilizumab treatment.Results: Of 342 patients, 86.0% had pl...

journal_title：Modern rheumatology

authors： Murakami M,Johkoh T,Hayashi S,Ohshima S,Mizuki M,Nakatsuka SI,Tomobe M,Kuroyanagi K,Nakasone A,Nishimoto N

更新日期：2020-09-01 00:00:00

abstract：:Objective: We conducted a questionnaire survey within a standard clinical setting to clarify that picture superiority effect (PSE) could be obtained by musculoskeletal ultrasound (MSKUS) examination.Methods: One hundred patients with rheumatoid arthritis or arthralgia, who visited the Rheumatology Unit, Department of ...

journal_title：Modern rheumatology

authors： Matsuki-Muramoto Y,Ogasawara M,Kawamoto T,Yamaji K,Tamura N

更新日期：2020-07-01 00:00:00

abstract：OBJECTIVES:To determine whether ultrasonography (US) predicts Boolean remission in rheumatoid arthritis (RA) patients who had achieved disease activity score in 28 joints (DAS28)-based remission criteria. METHODS:Thirty-one RA patients in DAS28-based clinical remission were recruited. US semiquantitatively determined ...

journal_title：Modern rheumatology

authors： Yoshimi R,Hama M,Minegishi K,Kishimoto D,Watanabe T,Kamiyama R,Kirino Y,Asami Y,Ihata A,Tsunoda S,Ueda A,Takeno M,Ishigatsubo Y

更新日期：2014-07-01 00:00:00

abstract：:We report a case of acute generalized pustular bacterid (AGPB) concomitant with erythema nodosum (EN), polyarthritis, and Achilles tendinitis. The patient was admitted with a complaint of fever, widespread plural pustules, erythema, and polyarthralgia. Histopathological examination of the skin lesions demonstrated fea...

journal_title：Modern rheumatology

authors： Arita Y,Taguchi H,Hanada R,Tono T,Ohsone Y,Okata U,Irie R,Okano Y

更新日期：2019-01-01 00:00:00

abstract：:We report the case of a 73-year-old man with myelodysplastic syndrome (MDS) who developed Weber-Christian disease (WCD). Bone marrow aspirates showed refractory anemia with abnormal karyotypes such as trisomy 8, trisomy 8 and 14, and trisomy 8, 9, and 14. The patient had intermittent fever associated with multiple ten...

journal_title：Modern rheumatology

authors： Hojo N,Hasegawa H,Iwamasa K,Hojo S,Fujita S

更新日期：2004-01-01 00:00:00

abstract：:To evaluate the composite disease activity indices for rheumatoid arthritis (RA), we compared disease activities and the changes therein calculated using the Disease Activity Score based on 28 joint counts using erythrocyte sedimentation rate (DAS28-ESR), DAS28-CRP (C-reactive protein), Simplified Disease Activity Ind...

journal_title：Modern rheumatology

authors： Matsui T,Kuga Y,Nishino J,Kaneko A,Eto Y,Tohma S

更新日期：2011-04-01 00:00:00

abstract：:Abstract Sensitivity and specificity were compared among the American College of Rheumatology (ACR) 1987 classification criteria, the Yamasaki diagnostic criteria, and the Japan Rheumatism Association (JRA) diagnostic criteria for early rheumatoid arthritis (RA). The study included 90 patients who consulted our depart...

journal_title：Modern rheumatology

authors： Yamamoto N,Hagino H,Teshima R

更新日期：2000-09-01 00:00:00

abstract：:Abstract The human major histocompatibility complex (MHC) class I gene HLA-B27 bears a striking association with ankylosing spondylitis and related spondyloarthropathies. This association transcends all ethnic and geographical boundaries. The primary function of HLA-B27 as an MHC class I protein is to form a complex w...

journal_title：Modern rheumatology

authors： Mehra NK,Kanga U

更新日期：2001-12-01 00:00:00

abstract：OBJECTIVE:The aims of this study are to determine the incidence of congenital heart block (CHB) in the Japanese population and identify maternal factors predicting fetal CHB in anti-Ro/SSA antibody positive pregnancy. METHODS:A retrospective study was performed using 52,147 clinical records of pregnancies followed in ...

journal_title：Modern rheumatology

authors： Miyasato-Isoda M,Waguri M,Yamada Y,Miyano A,Wada Y

更新日期：2018-07-01 00:00:00

abstract：:The influence of estrogen therapy on changes in arthritis and bone mineral density (BMD) was evaluated using an estrogen-replete collagen-induced arthritis (CIA) rat model. Seven-month-old female Sprague-Dawley rats (n = 30) were divided into the three groups; control (CONT), collagen sensitization (CIA), and CIA + 17...

journal_title：Modern rheumatology

authors： Yoshioka T,Hagino H,Yamasaki D,Okano T,Teshima R

更新日期：2008-01-01 00:00:00

abstract：OBJECTIVES:Joint space narrowing and osteophyte formation, radiographic features of knee osteoarthritis (OA), are not necessarily synchronous processes. We evaluated the relationship between medial minimum joint space width (mJSW) and osteophyte formation. METHODS:We conducted a retrospective study of 1050 individuals...

journal_title：Modern rheumatology

authors： Komatsu D,Hasegawa Y,Kojima T,Seki T,Higuchi Y,Ishiguro N

更新日期：2017-07-01 00:00:00

abstract：INTRODUCTION:Assessment of synovitis in the metatarsophalangeal (MTP) joints with ultrasound has been shown to improve the accuracy of assessment of rheumatoid arthritis (RA). However, the presence of intraarticular low-echoic synovial area (LESA) in the MTP joints in healthy subjects complicates the sonographic assess...

journal_title：Modern rheumatology

authors： Hiraga M,Ikeda K,Shigeta K,Sato A,Yoshitama T,Hara R,Tanaka Y

更新日期：2015-05-01 00:00:00

abstract：:Abstract  This study examined the pathogenesis of large pseudocysts adjacent to knee joints in rheumatoid arthritis (RA). The radiological and histopathological features of 17 large subarticular pseudocysts in 12 knee joints of 10 patients were analyzed. Nine of the 10 patients were classified as class 2 according to ...

journal_title：Modern rheumatology

authors： Yoshida M,Ichinohe S,Uzuki M,Yoshida W,Sawai T,Shimamura T

更新日期：2002-06-01 00:00:00

abstract：:We report two cases of clinically amyopathic dermatomyositis (CADM) complicated by rapid progress interstitial lung disease (RPILD). The diagnosis of CADM was based on Gottron's papule and RPILD, and the absence of muscle weakness. The female patients were treated with early immunosuppressive therapies including stero...

journal_title：Modern rheumatology

authors： Horai Y,Isomoto E,Koga T,Okada A,Kawashiri SY,Tamai M,Yamasaki S,Nakamura H,Origuchi T,Hamaguchi Y,Fujimoto M,Kuwana M,Kawakami A

更新日期：2013-01-01 00:00:00

abstract：:Pneumatosis cystoides intestinalis (PCI), which is characterized by the presence of multiple gas-filled mucosal, submucosal, or subserosal cysts located throughout the colon and/or small intestine, is an unusual complication of systemic lupus erythematosus (SLE). We report a case of a 33-year-old woman with a 5-year h...

journal_title：Modern rheumatology

authors： Yamaguchi Y,Ohno S,Yamazaki S,Ideguchi H,Shirai A,Takeno M,Ishigatsubo Y

更新日期：2005-01-01 00:00:00

abstract：:Tocilizumab (TCZ) is an interleukin-6 (IL-6) inhibitor used for the treatment of rheumatoid arthritis (RA). It was developed in 2008, and its effectiveness is supported by evidence from all over the world based on its first decade of use. Although the overall efficacy and safety profiles of TCZ are similar to those of...

journal_title：Modern rheumatology

authors： Ogata A,Kato Y,Higa S,Yoshizaki K

更新日期：2019-03-01 00:00:00

abstract：: ...

journal_title：Modern rheumatology

authors： Hatta Y,Hasegawa M,Matsushita T,Hamaguchi Y,Fujimoto M,Takehara K

更新日期：2013-04-27 00:00:00

abstract：:We conducted a comprehensive meta-analysis to quantitatively evaluate the association of cytokine gene polymorphisms with systemic sclerosis (SSc) susceptibility. Electronic databases were used to identify published studies before July 2011. In total, 23 case-control studies including 3524 SSc cases and 6086 healthy c...

journal_title：Modern rheumatology

authors： Peng WJ,Pan HF,Tao JH,Wang BX,Lu MM,Wang S,He Q,Wang J

更新日期：2012-09-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a very heterogeneous systemic autoimmune disease, in which autoantibody synthesis against nuclear constituents is the main immunological characteristic. These autoantibodies underwent affinity maturation and isotype switching. Additionally, T-cell tolerance against nuclear autoant...

journal_title：Modern rheumatology

authors： Grossmayer GE,Munoz LE,Gaipl US,Franz S,Sheriff A,Voll RE,Kalden JR,Herrmann M

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVES:Gout is a polygenic auto-inflammatory disease, in which inflammation plays an important role in disease pathogenesis. The cytokine interleukin (IL)-23 promotes inflammation and helps to guide inflammatory cells, while studies have shown that the IL-23R gene is associated with susceptibility to several immune...

journal_title：Modern rheumatology

authors： Liu S,He H,Yu R,Han L,Wang C,Cui Y,Li C

更新日期：2015-05-01 00:00:00

abstract：OBJECTIVES:We aimed to clarify the characteristics of heme oxygenase (HO)-1 expressing cells in the synovium from rheumatoid arthritis (RA) and osteoarthritis (OA), and to investigate the co-expression of HO-1 and IgG-Fc/HLA-DR complex. METHODS:The characteristics of HO-1 expressing cells in the synovium were investig...

journal_title：Modern rheumatology

authors： Yang S,Ohe R,Aung NY,Kato T,Kabasawa T,Utsunomiya A,Takakubo Y,Takagi M,Yamakawa M

更新日期：2021-01-01 00:00:00

abstract：:The current study investigates the role of regulatory T (Treg) cells in the pathogenesis of ocular attack in patients with Behcet's disease (BD). Nineteen BD patients with ocular complications (BDo), including 11 BD patients with ocular attack (BDa) and eight BD patients with inactive ocular complications (BDi), were ...

journal_title：Modern rheumatology

authors： Nanke Y,Kotake S,Goto M,Ujihara H,Matsubara M,Kamatani N

更新日期：2008-01-01 00:00:00

abstract：OBJECTIVE:This study aimed to evaluate whether the level of serum matrix metalloproteinase-3 (MMP-3), a marker of synovium inflammation, is affected by clinical characteristics of patients in rheumatoid arthritis (RA) patients. METHODS:We analyzed data from 1087 female patients with RA. Pearson's correlation coefficie...

journal_title：Modern rheumatology

authors： Hattori Y,Kida D,Kaneko A

更新日期：2018-03-01 00:00:00

abstract：:To investigate the precise modality of association between SAA1 gene polymorphisms and the development of AA amyloidosis in patients with rheumatoid arthritis (RA), Japanese patients with RA (n=153), among whom 29 were histologically diagnosed as having amyloidosis, were genotyped for three single nucleotide polymorph...

journal_title：Modern rheumatology

authors： Ajiro J,Narita I,Sato F,Saga D,Hasegawa H,Kuroda T,Nakano M,Gejyo F

更新日期：2006-01-01 00:00:00

abstract：OBJECTIVES:In this study, we aimed to assess the effect of combination of proliferative and membranous lesions (Class III + V or IV + V) on renal outcomes as an independent category distinct from Class III and IV. METHODS:We retrospectively analyzed 103 Japanese patients (14 male and 89 female) with Class III/IV LN, w...

journal_title：Modern rheumatology

authors： Ikeuchi H,Hiromura K,Kayakabe K,Tshilela KA,Uchiyama K,Hamatani H,Sakairi T,Kaneko Y,Maeshima A,Nojima Y

更新日期：2016-11-01 00:00:00

abstract：OBJECTIVES:To evaluate the therapeutic efficacy of a novel inhibitor for IκB kinase alpha (IKKα), noraristeromycin (NAM), for murine experimental model of rheumatoid arthritis, collagen- induced arthritis (CIA). METHODS:NAM has been chemically synthesized as reported earlier. CIA was induced in DBA/1JNCrlj mice by int...

journal_title：Modern rheumatology

authors： Ito M,Hamano T,Komatsu T,Asamitsu K,Yamakawa T,Okamoto T

更新日期：2014-09-01 00:00:00