Abstract:
:Abstract The human major histocompatibility complex (MHC) class I gene HLA-B27 bears a striking association with ankylosing spondylitis and related spondyloarthropathies. This association transcends all ethnic and geographical boundaries. The primary function of HLA-B27 as an MHC class I protein is to form a complex with β2-microglobulin resulting in a structure that is capable of presenting short antigenic peptides for recognition by cytotoxic T lymphocytes. HLA-B27 represents a family of 23 closely related alleles (B (*) 2701-23) called subtypes of HLA-B27, most of which have evolved from B (*) 2705. Studies from different parts of the world reveal differences in the population distribution. HLA-B27 subtypes are characterized by nucleotide substitutions (mostly nonsynonymous) in exons 2 and 3 which encode α1 and α2 domains of the peptide binding groove respectively. Gene conversion, point mutation, genetic draft, and recombination events are various mechanisms leading to heterogeneity of HLA-B27 and its evolution. Clustering of differences in the C/F pockets of HLA-B27 influences the peptide binding. Thus variations in strength of disease association of various HLA-B27 subtypes may be due to differences in peptide interaction of HLA-B27 subtypes. Because the association between HLA-B27 and disease is not absolute, possible influence of other genes on disease susceptibility needs further investigation. In this regard, the role of several candidate genes that include non-B27 MHC genes, MHC-related genes, MHC genes involved in antigen processing and transplant, cytokine genes, and markers on other chromosomes may be important. Besides these significant developments, satisfactory answers to many unresolved issues are sought. Understanding the exact mechanism of the HLA-B27 and disease association is continuing to be a subject of many studies.
journal_name
Mod Rheumatoljournal_title
Modern rheumatologyauthors
Mehra NK,Kanga Udoi
10.3109/s10165-001-8056-0subject
Has Abstractpub_date
2001-12-01 00:00:00pages
275-85issue
4eissn
1439-7595issn
1439-7609journal_volume
11pub_type
杂志文章abstract::IgG4-related disease (IgG4-RD) is a fascinating clinical entity first reported in this century in Japan, and includes a wide variety of diseases, such as formerly named Mikulicz's disease (MD), autoimmune pancreatitis (AIP), interstitial nephritis, prostatitis and retroperitoneal fibrosis. The Japanese IgG4 team organ...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2020.1859710
更新日期:2021-01-28 00:00:00
abstract::Leuconostoc infections are rare and usually occur in immunocompromised patients. This report describes a case of Leuconostoc lactis bacteremia in a patient with coexisting rheumatoid arthritis and tuberculosis arthritis. A disrupted gastrointestinal barrier due to gastrointestinal amyloidosis in long-standing rheumato...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-011-0465-0
更新日期:2011-12-01 00:00:00
abstract:OBJECTIVES:Several biological disease-modifying antirheumatic drugs (bDMARDs) are currently available for the treatment of rheumatoid arthritis (RA). Increasing evidence indicates that second-line bDMARDs are effective for inadequate responders to first-line bDMARDs. However, all previous studies investigated the use o...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2016.1206242
更新日期:2017-03-01 00:00:00
abstract:OBJECTIVES:To assess the efficacy and safety of intravenous (IV) belimumab plus standard systemic lupus erythematosus (SLE) therapy standard of care (SoC) in Japanese patients with SLE. METHODS:A Phase 3, multicenter, double-blind, placebo-controlled, 52-week study (BEL 113750; NCT01345253) in patients with SLE, rando...
journal_title:Modern rheumatology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1080/14397595.2018.1480915
更新日期:2019-05-01 00:00:00
abstract:OBJECTIVES:Anti-cytokine therapy is reportedly useful in amyloid A (AA) amyloidosis complicating rheumatic diseases. However, to date no studies have directly compared the utility of tumour necrosis factor (TNF) inhibition to that of interleukin-6. The aim of our retrospective study was to compare the clinical utility ...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2013.854048
更新日期:2014-01-01 00:00:00
abstract::Aortitis, inflammation of the aortic tissue, is most commonly caused by vasculitic rheumatic conditions, and less frequently infectious organisms. Involvement of the aorta is well defined in HLA-B27-associated spondyloarthropathies such as long-standing ankylosing spondylitis and Reiter's syndrome. However, unlike oth...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-011-0566-9
更新日期:2012-09-01 00:00:00
abstract::Bucillamine (Buc) is a disease-modifying antirheumatic drug (DMARD) developed in Japan, which has been used as one of the first-line DMARDs for the treatment of rheumatoid arthritis (RA) in Japan. However, direct comparison of this drug with standard DMARDs including sulfasalazine (SASP) and methotrexate (MTX) has bee...
journal_title:Modern rheumatology
pub_type: 临床试验,杂志文章
doi:10.1007/s10165-006-0527-x
更新日期:2006-01-01 00:00:00
abstract:OBJECTIVE:To clarify polyarticular juvenile idiopathic arthritis (pJIA) patients who failed to maintain prolonged remission with the first biologic agent. METHODS:Fourteen pJIA patients were observed for 47.5 months (median) after initiating the first biologic agent. RESULTS:Eight maintained sustained clinical remiss...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2015.1083147
更新日期:2016-01-01 00:00:00
abstract:AIM:The aim of this study was to analyze the effect of 18-week functional training (FT) program consisting in two sessions a week of in-water exercise and one of on-land exercise on pain, strength, and balance in women with fibromyalgia. METHODS:A sample consisting of 36 fibromyalgia patients was included in the study...
journal_title:Modern rheumatology
pub_type: 杂志文章,随机对照试验
doi:10.3109/14397595.2015.1040614
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:The aims of this study are to determine the incidence of congenital heart block (CHB) in the Japanese population and identify maternal factors predicting fetal CHB in anti-Ro/SSA antibody positive pregnancy. METHODS:A retrospective study was performed using 52,147 clinical records of pregnancies followed in ...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2017.1374235
更新日期:2018-07-01 00:00:00
abstract::Abstract To clarify the effect of leukemia inhibitory factor (LIF) on the destruction of rheumatoid arthritis (RA) joints, we investigated the production of LIF and the expression of LIF mRNA in synovial tissues from patients with RA and osteoarthritis (OA). Synovial fluids from RA were used to measure the LIF concent...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/s10165-002-0210-9
更新日期:2003-06-01 00:00:00
abstract::A 79-year-old man was diagnosed with relapsing polychondritis, from symptoms of bilateral auricular deformity and pigmentation, polyarthralgia, and audiovestibular damage, and from histological examination of the left auricular cartilage. The left auricular cartilage biopsy specimen revealed cartilage destruction with...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-011-0439-2
更新日期:2011-10-01 00:00:00
abstract:OBJECTIVES:Our primary objective was to retrospectively analyze whether bisphosphonates initiated in combination with immunosuppressive drugs and/or intravenous immunoglobulin (IVIG) resulted in a radiological and clinical improvement of dystrophic calcinosis in six female juvenile dermatomyositis (JDM) patients. METH...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2014.988197
更新日期:2015-07-01 00:00:00
abstract::An association between thrombotic thrombocytopenic purpura (TTP) and Sjögren's syndrome (SS) is rare. This is the first report of two patients with TTP who had inhibitory autoantibodies to ADAMTS13 (a disintegrin-like and metalloprotease with thrombospondin type 1 repeats) complicating primary SS. A rapid diagnosis of...
journal_title:Modern rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10165-012-0644-7
更新日期:2013-03-01 00:00:00
abstract::A 52-year-old woman with a 6-year history of systemic lupus erythematosus (SLE) developed acute abdominal pain, nausea, vomiting, and diarrhea accompanied by hypocomplementemia. Herpes simplex virus (HSV) esophagitis and lupus enteritis were diagnosed on the basis of the results of endoscopic and histological examinat...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-009-0237-2
更新日期:2010-02-01 00:00:00
abstract:OBJECTIVE:This retrospective study was designed to evaluate the outcomes of four different surgical reconstructions for extensor tendon ruptures in ulnar three fingers in 48 patients with rheumatoid arthritis. METHODS:The following four techniques were performed; palmaris longus tendon grafting (PL group; n = 9), exte...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2015.1070446
更新日期:2016-01-01 00:00:00
abstract::Objectives: The Childhood Health Assessment Questionnaire (CHAQ) is one of the most widely used self- report questionnaires to measure functional status in Juvenile idiopathic arthritis (JIA). The Japanese version of the CHAQ (JCHAQ) has been revised to meet requirements of clinical international trials which need the...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2019.1660027
更新日期:2020-09-01 00:00:00
abstract::OBJECTIVES: To validate the 2010 histopathological classification system of anti-neutrophil cytoplasmic antibodies (ANCA)-associated glomerulonephritis (GN) in a Japanese single-center cohort. METHODS: We retrospectively studied 54 patients (28 renally limited pauci-immune GN, 25 microscopic polyangiitis, and one Chur...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-013-0877-0
更新日期:2013-04-12 00:00:00
abstract:OBJECTIVES:To evaluate joint inflammation using 3-T MRI in rheumatoid arthritis (RA) patients treated with conventional disease modifying anti-rheumatic drugs (cDMARDs) as compared to inhibitors for tumor necrosis factor α (TNFi) over 12 months. METHODS:Prospective epidemiologic clinical pilot study using the RA MRI s...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2018.1467525
更新日期:2019-05-01 00:00:00
abstract::We evaluated the utility of HEp-2 cells transfected with the 60 kDa SS-A/Ro as a substrate for indirect immunofluorescence (IIF-HEp-2000) to compare several methods for screening Japanese serum samples for anti-SS-A/Ro antibodies. Serum samples from 243 Japanese patients were analyzed by IIF for anti-nuclear antibodie...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-008-0100-x
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVE:The aim of the present study was to investigate the efficacy of arthroscopic enlargement of unidirectional valvular slits for the treatment of popliteal cysts and to evaluate potential factors affecting the outcomes of our arthroscopic procedure. METHODS:Twenty-nine patients aged 43-77 years with popliteal c...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2015.1008779
更新日期:2015-09-01 00:00:00
abstract::Abstract This study examined the pathogenesis of large pseudocysts adjacent to knee joints in rheumatoid arthritis (RA). The radiological and histopathological features of 17 large subarticular pseudocysts in 12 knee joints of 10 patients were analyzed. Nine of the 10 patients were classified as class 2 according to ...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/s101650200022
更新日期:2002-06-01 00:00:00
abstract::Abstract Sensitivity and specificity were compared among the American College of Rheumatology (ACR) 1987 classification criteria, the Yamasaki diagnostic criteria, and the Japan Rheumatism Association (JRA) diagnostic criteria for early rheumatoid arthritis (RA). The study included 90 patients who consulted our depart...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/s101650070020
更新日期:2000-09-01 00:00:00
abstract::Abstract Methotrexate (MTX) is the most commonly used disease-modifying antirheumatic drug (DMARD) throughout the world. In Japan, MTX is recommended by the Japanese Ministry of Health, Labour, and Welfare to be given as the second or third DMARD and at a dosage of no more than 8 mg/week. We analyzed the efficacy of M...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/s10165-004-0340-3
更新日期:2004-12-01 00:00:00
abstract:OBJECTIVE:Evaluate the association between the multi-biomarker disease activity (MBDA) score and radiographic progression in patients with rheumatoid arthritis (RA) treated with tumor necrosis factor (TNF)-α inhibitors. METHODS:Change (Δ) in modified total Sharp score (mTSS) over 52 weeks and disease activity scores w...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2016.1153449
更新日期:2016-11-01 00:00:00
abstract::The aim of our study was to determine the spectrum of the 12 most common familial Mediterranean fever gene (MEFV) mutations in Iranian patients with heterogeneous ethnicity, using the familial Mediterranean fever (FMF) strip assay test. A total of 36 patients were diagnosed according to established clinical criteria. ...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-010-0317-3
更新日期:2010-12-01 00:00:00
abstract:OBJECTIVES:Pathogenesis and risk factors of scleroderma associated calcinosis is poorly understood and there is no effective treatment. This study was performed to better understand the prevalence and clinical features associated with calcinosis in a cohort of SSc outpatients. METHODS:In this cross-sectional study, we...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2017.1349594
更新日期:2018-05-01 00:00:00
abstract:AIM:Interleukin-6 receptor antagonist, tocilizumab (TCZ), is known to be effective in the treatment of amyloidosis in patients with familial Mediterranean fever (FMF). But there are limited data about the effect of TCZ on frequency of attacks. In the current study, we aimed to find out whether TCZ therapy could decreas...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2019.1709258
更新日期:2021-01-01 00:00:00
abstract::An 8-year-old girl with systemic-onset juvenile idiopathic arthritis (JIA) required surgical reduction for a dislocated left hip joint following failure of skin traction for 1 week. Unaided walking was achieved by 3 months postoperatively. Incongruence and irregularity of the hip joint remained but may resolve with ma...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-004-0330-5
更新日期:2004-01-01 00:00:00
abstract::A retrospective study was performed to investigate the clinical and radiological results of the Sauvé-Kapandji (S-K) procedure for the rheumatoid wrist. One hundred and eight rheumatoid wrists in 98 patients were operated on in our institute from 1992 to 2000, and in 82 wrists we used the S-K procedure. In other cases...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-004-0297-2
更新日期:2004-01-01 00:00:00