Abstract:
OBJECTIVES:To evaluate the therapeutic efficacy of a novel inhibitor for IκB kinase alpha (IKKα), noraristeromycin (NAM), for murine experimental model of rheumatoid arthritis, collagen- induced arthritis (CIA). METHODS:NAM has been chemically synthesized as reported earlier. CIA was induced in DBA/1JNCrlj mice by intradermal inoculation of bovine type II collagen (col II) together with Freund Complete Adjuvant. Following the Day 21 booster injection of col II with Freund Incomplete Adjuvant, the animals were monitored for the development of arthritis and clinically evaluated. NAM was administered orally at different doses prior to induction (prophylactic protocol) or after the emergence of definitive arthritis (therapeutic protocol). RESULTS:Here we demonstrate the experimental evidence that oral administration of NAM could completely prevent the occurrence of experimental arthritis in CIA mouse model at 0.3 mg/kg with ED50 value of approximately 0.1 mg/kg twice daily. Moreover, twice daily oral therapeutic dosage of 1 mg/kg of NAM significantly inhibited the paw swelling and disease progression even after the occurrence of experimental CIA. In addition, NAM exhibited an excellent pharmacokinetics in mice and oral administration of NAM could suppress the production of TNFα elicited by lipopolysaccharide (LPS) in a dose-dependent manner. CONCLUSIONS:These results indicated that IKKα inhibition is an effective novel therapy for the treatment of chronic inflammatory processes such as those associated with RA and other related conditions.
journal_name
Mod Rheumatoljournal_title
Modern rheumatologyauthors
Ito M,Hamano T,Komatsu T,Asamitsu K,Yamakawa T,Okamoto Tdoi
10.3109/14397595.2013.879416subject
Has Abstractpub_date
2014-09-01 00:00:00pages
775-80issue
5eissn
1439-7595issn
1439-7609journal_volume
24pub_type
杂志文章abstract:OBJECTIVES:Our primary objective was to retrospectively analyze whether bisphosphonates initiated in combination with immunosuppressive drugs and/or intravenous immunoglobulin (IVIG) resulted in a radiological and clinical improvement of dystrophic calcinosis in six female juvenile dermatomyositis (JDM) patients. METH...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2014.988197
更新日期:2015-07-01 00:00:00
abstract:OBJECTIVE:This retrospective study was designed to evaluate the outcomes of four different surgical reconstructions for extensor tendon ruptures in ulnar three fingers in 48 patients with rheumatoid arthritis. METHODS:The following four techniques were performed; palmaris longus tendon grafting (PL group; n = 9), exte...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2015.1070446
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVES:To evaluate the long-term efficacy and safety of certolizumab pegol (CZP) plus methotrexate treatment and to assess the efficacy of two CZP maintenance dosing schedules in Japanese rheumatoid arthritis (RA) patients with an inadequate response to methotrexate. METHODS:J-RAPID double-blind patients were ente...
journal_title:Modern rheumatology
pub_type: 杂志文章,随机对照试验
doi:10.3109/14397595.2014.881709
更新日期:2014-09-01 00:00:00
abstract::Abstract We report a rare case of a 17-year-old female with overlap syndrome (systemic lupus erythematosus and systemic sclerosis) who developed severe abdominal pain and bloody diarrhea accompanied by central nervous system lupus. Colonoscopy revealed multiple irregular and linear ulcers throughout the colon, which w...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/s10165-003-0243-8
更新日期:2003-12-01 00:00:00
abstract:OBJECTIVES:Modern three-component total ankle arthroplasty (TAA) has favorable clinical results and survival rates. However, radiographic deterioration and worsening of clinical symptoms may occur in patients with rheumatoid arthritis (RA) or non-inflammatory arthritis (NA). The associations between outcomes and clinic...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2016.1220049
更新日期:2017-05-01 00:00:00
abstract::Abstract Sensitivity and specificity were compared among the American College of Rheumatology (ACR) 1987 classification criteria, the Yamasaki diagnostic criteria, and the Japan Rheumatism Association (JRA) diagnostic criteria for early rheumatoid arthritis (RA). The study included 90 patients who consulted our depart...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/s101650070020
更新日期:2000-09-01 00:00:00
abstract:BACKGROUND:The aim of the present study was to analyze the score of fatigue in a large cohort of Brazilian patients with SpA, comparing different disease patterns and its association with demographic and disease-specific variables. METHODS:A common protocol of investigation was prospectively applied to 1492 Brazilian ...
journal_title:Modern rheumatology
pub_type: 杂志文章,多中心研究
doi:10.3109/14397595.2014.906049
更新日期:2014-11-01 00:00:00
abstract::Objectives: In this study, we aimed to evaluate the level of central sensitization (CS) and its relationship with health profile, including neuropathic pain and sleep quality in Behçet's disease (BD).Method: Eighty-eight patients with BD and 60 healthy controls (HCs) were included in the study between May 2018 and Feb...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2020.1780076
更新日期:2020-07-06 00:00:00
abstract::Objectives: To assess the clinicopathologic features of Multicentric Castleman disease (MCD) patients in Japan.Methods: We assessed baseline data for 342 Japanese MCD patients with a biopsy-proven diagnosis, enrolled in a prospective, observational study for tocilizumab treatment.Results: Of 342 patients, 86.0% had pl...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2019.1704983
更新日期:2020-09-01 00:00:00
abstract:OBJECTIVES:Anticentromere antibody (ACA) is generally considered to be a serological marker for systemic sclerosis (SSc). ACA-positive patients with primary Sjögren's syndrome (pSS) have also been reported. ACA often recognizes centromere proteins (CENPs): CENP-A, CENP-B, and CENP-C, and sometimes reacts to heterochrom...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2016.1176327
更新日期:2017-01-01 00:00:00
abstract::Synovial vascularization in the knee joints of six patients with rheumatoid arthritis who were treated with infliximab was evaluated by Doppler sonography. Power Doppler sonography demonstrated a significant reduction of color flow signals (P < 0.05), and spectral Doppler sonography demonstrated a significant increase...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-004-0359-5
更新日期:2005-01-01 00:00:00
abstract::Cutaneous polyarteritis nodosa (CPAN) is a form of necrotizing vasculitis of small and medium-sized arteries. It is limited to the skin and has a recurrent and chronic course, possibly associated with fever, arthralgia, myalgia and neuropathy, but without visceral involvement. We report the clinical case of a 7-year-o...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2013.874737
更新日期:2014-07-01 00:00:00
abstract:BACKGROUND:Colchicine is the mainstay of the treatment of familial Mediterranean fever (FMF). However, 10% of FMF patients do not respond well to colchicine. Efficacy of interleukin (IL)-1 inhibitors in reducing attacks have been demonstrated in colchicine-resistant FMF (crFMF) patients recently. Colchicine is still th...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2018.1457469
更新日期:2019-03-01 00:00:00
abstract::Aortitis, inflammation of the aortic tissue, is most commonly caused by vasculitic rheumatic conditions, and less frequently infectious organisms. Involvement of the aorta is well defined in HLA-B27-associated spondyloarthropathies such as long-standing ankylosing spondylitis and Reiter's syndrome. However, unlike oth...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-011-0566-9
更新日期:2012-09-01 00:00:00
abstract::Nintedanib (Ofev™), an oral triple kinase inhibitor targeting pro-fibrotic pathways, has been used for treatment of idiopathic pulmonary fibrosis (IPF). Based on positive results from phase III, placebo-controlled, randomized comparative clinical trial conducted in patients with systemic sclerosis-associated interstit...
journal_title:Modern rheumatology
pub_type: 杂志文章,评审
doi:10.1080/14397595.2019.1696505
更新日期:2020-03-01 00:00:00
abstract::We conducted a comprehensive meta-analysis to quantitatively evaluate the association of cytokine gene polymorphisms with systemic sclerosis (SSc) susceptibility. Electronic databases were used to identify published studies before July 2011. In total, 23 case-control studies including 3524 SSc cases and 6086 healthy c...
journal_title:Modern rheumatology
pub_type: 杂志文章,meta分析
doi:10.1007/s10165-011-0574-9
更新日期:2012-09-01 00:00:00
abstract:OBJECTIVES:Lupus enteritis (LE) is a rare but well-known gastrointestinal manifestation of systemic lupus erythematosus (SLE). This study was conducted to identify prognostic factors associated with poor responses in patients with LE. METHODS:We consecutively registered patients diagnosed with LE between January 2009 ...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2020.1812871
更新日期:2020-09-07 00:00:00
abstract::The involvement of valgus hindfoot deformity in hallux valgus deformity was confirmed in a rheumatoid arthritis case with a destructive valgus hindfoot deformity. Correction of severe valgus, calcaneal lateral offset, and pronated foot deformity instantly normalized hallux valgus deformities postoperatively. Thus, car...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2013.874738
更新日期:2014-09-01 00:00:00
abstract::Inflammation has often been considered to be a nonspecific response and to play a bridging role in the activation of adaptive immunity. However, it is now accepted that inflammation is the product of an independent innate immune system closely linked to the adaptive immune system. The key mediators of inflammation are...
journal_title:Modern rheumatology
pub_type: 杂志文章,评审
doi:10.3109/14397595.2014.902747
更新日期:2015-01-01 00:00:00
abstract::The aim of this study was to investigate the reliability and the validity of the Japanese version of the 2010 American College of Rheumatology Preliminary Diagnostic Criteria for Fibromyalgia (ACR 2010-J), and its quantification scale, the Fibromyalgia Symptom Scale (FS-J). In this study, we divided patients with chro...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-011-0462-3
更新日期:2012-02-01 00:00:00
abstract:OBJECTIVE:We examined the prevalence and risk factors of vertebral fracture in female Japanese patients with systemic lupus erythematosus (SLE). METHODS:We performed lateral radiographs of the thoracic and lumbar spine and bone mineral density (BMD) measurements and collected demographic, lifestyle, clinical, and trea...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-012-0735-5
更新日期:2013-07-01 00:00:00
abstract::Risk of knee osteoarthritis (OA) was assessed in a population-based case-control study of Japanese men. The study covered three health districts in Wakayama and Osaka prefectures, Japan. Subjects were male individuals >or=45 years old diagnosed radiographically with knee OA, and who did not display any established cau...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-005-0450-6
更新日期:2006-01-01 00:00:00
abstract::Abstract A 56-year-old man presented with hyperproteinemia and renal dysfunction associated with antineutrophil cytoplasmic antibodies (ANCA). He had had a ventriculoperitoneal shunt tube made of silicone implanted 4 years earlier. In his renal biopsy, necrotizing crescentic glomerulonephritis was identified: tests fo...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/s101650300011
更新日期:2003-03-01 00:00:00
abstract::We examined the therapeutic effect of high molecular weight hyaluronic acid (HA) on the progression of joint pain and cartilage degeneration in a rabbit osteoarthritis (OA) model. The OA model was induced by partial meniscectomy. In the time course study, cartilage degeneration was assessed at 3, 7 and 14 days after o...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-010-0299-1
更新日期:2010-10-01 00:00:00
abstract::Interstitial lung disease (ILD) is a noteworthy condition in the treatment of systemic sclerosis (SSc) because of its associated mortality and morbidity; however, the efficacy of various treatments for ILD has been controversial in previous reports. In this study, we examined the efficacy and safety of intravenous cyc...
journal_title:Modern rheumatology
pub_type: 临床试验,杂志文章
doi:10.1007/s10165-010-0403-6
更新日期:2011-06-01 00:00:00
abstract::We performed total hip arthroplasty using the non-cement impaction auto-bone-grafting method with the resected femoral head for acetabular protrusion that is not combined with the destruction of acetabular rim or dysplasia of the hip joint. Ten patients (eight women and two men) with rheumatoid arthritis who showed ac...
journal_title:Modern rheumatology
pub_type: 临床试验,杂志文章
doi:10.1007/s10165-007-0571-1
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVES:To evaluate the scoring of whole-body magnetic resonance imaging (WBMRI) for efficacy assessment in rheumatoid arthritis (RA) patients receiving biological disease-modifying anti-rheumatic drugs (bDMARDs). METHODS:Thirty consecutive RA patients receiving bDMARDs were included in this retrospective study. Co...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2016.1276425
更新日期:2017-11-01 00:00:00
abstract:OBJECTIVES:To assess gout and asymptomatic hyperuricemia in Japan and review treatment conditions. METHODS:This retrospective cross-sectional study analyzed the prevalence of hyperuricemia and gout, and characteristics and treatment of patients with those conditions, using Japanese health insurance claims and medical ...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2020.1784556
更新日期:2021-01-01 00:00:00
abstract::A retrospective study was performed to investigate the clinical and radiological results of the Sauvé-Kapandji (S-K) procedure for the rheumatoid wrist. One hundred and eight rheumatoid wrists in 98 patients were operated on in our institute from 1992 to 2000, and in 82 wrists we used the S-K procedure. In other cases...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-004-0297-2
更新日期:2004-01-01 00:00:00
abstract::Hyperimmunoglobulin E syndrome (HIES) is a primary immunodeficiency disorder with multisystem abnormalities including the vascular system. We report a child with autosomal recessive (AR)-HIES secondary to dedicator of cytokinesis 8 (DOCK8) deficiency who developed critical aortic aneurysm involving the ascending aorta...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2013.874735
更新日期:2014-07-01 00:00:00