Abstract:
OBJECTIVES:We aimed to clarify the characteristics of heme oxygenase (HO)-1 expressing cells in the synovium from rheumatoid arthritis (RA) and osteoarthritis (OA), and to investigate the co-expression of HO-1 and IgG-Fc/HLA-DR complex. METHODS:The characteristics of HO-1 expressing cells in the synovium were investigated by using immunohistochemistry. The co-expression of HO-1 and IgG-Fc/HLA-DR complex was examined by an in situ proximity ligation assay (PLA) with immunofluorescence. HO-1 mRNA was investigated by reverse transcription-polymerase chain reaction. RESULTS:The number of HO-1+ cells from the RA synovium is higher than that from OA synovium. The double positive cells of HO-1 and IgG-Fc/HLA-DR complex were detected by the in situ PLA with immunofluorescence in RA synovium. HO-1 mRNA was detected in both RA and OA synovium. CONCLUSION:A portion of HO-1+ cells with IgG-Fc/HLA-DR complex in lining layer of RA may be concluded as one of antigen presenting cells in RA and may be involved in production of RF.
journal_name
Mod Rheumatoljournal_title
Modern rheumatologyauthors
Yang S,Ohe R,Aung NY,Kato T,Kabasawa T,Utsunomiya A,Takakubo Y,Takagi M,Yamakawa Mdoi
10.1080/14397595.2019.1704976subject
Has Abstractpub_date
2021-01-01 00:00:00pages
133-140issue
1eissn
1439-7595issn
1439-7609journal_volume
31pub_type
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journal_title:Modern rheumatology
pub_type: 杂志文章
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journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2016.1170958
更新日期:2017-01-01 00:00:00
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journal_title:Modern rheumatology
pub_type: 杂志文章
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更新日期:2016-01-01 00:00:00
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journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-008-0120-6
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doi:10.3109/14397595.2013.874761
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pub_type: 杂志文章
doi:10.3109/14397595.2014.988197
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pub_type: 临床试验,杂志文章
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pub_type: 杂志文章
doi:10.3109/s10165-002-0220-7
更新日期:2003-06-01 00:00:00
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pub_type: 杂志文章
doi:10.3109/s10165-004-0340-3
更新日期:2004-12-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2013-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:2021-01-28 00:00:00
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pub_type: 杂志文章,评审
doi:10.1007/s10165-011-0487-7
更新日期:2012-02-01 00:00:00