Involvement of IL-33 in the pathogenesis of rheumatoid arthritis: the effect of etanercept on the serum levels of IL-33.

abstract：:Tocilizumab (TCZ) is an interleukin-6 (IL-6) inhibitor used for the treatment of rheumatoid arthritis (RA). It was developed in 2008, and its effectiveness is supported by evidence from all over the world based on its first decade of use. Although the overall efficacy and safety profiles of TCZ are similar to those of...

journal_title：Modern rheumatology

authors： Ogata A,Kato Y,Higa S,Yoshizaki K

更新日期：2019-03-01 00:00:00

abstract：:We performed total hip arthroplasty using the non-cement impaction auto-bone-grafting method with the resected femoral head for acetabular protrusion that is not combined with the destruction of acetabular rim or dysplasia of the hip joint. Ten patients (eight women and two men) with rheumatoid arthritis who showed ac...

journal_title：Modern rheumatology

authors： Mochida Y,Saito I,Akamatsu Y,Taki N,Mitsugi N,Saito T

更新日期：2007-01-01 00:00:00

abstract：OBJECTIVES:The purpose of this study was to clarify the characteristics of bony ankylosis of the facet joint of the cervical spine in rheumatoid arthritis (RA) patients who required cervical spine surgery, and its relationship to the clinical findings. METHODS:Eighty consecutive RA patients with cervical spine disorde...

journal_title：Modern rheumatology

authors： Iizuka H,Iizuka Y,Okamura K,Yonemoto Y,Mieda T,Takagishi K

更新日期：2017-09-01 00:00:00

abstract：:Abstract Gout is a disease caused by an inflammatory response to an aggregation of monosodium urate crystals that develop secondary to hyperuricemia. Throughout its natural history it has four stages: asymptomatic hyperuricemia, acute gouty arthritis, intercritical gout, and chronic tophaceous gout. In this article, w...

journal_title：Modern rheumatology

authors： Tosun AK,Koca NT,Karataş GK

更新日期：2004-09-01 00:00:00

abstract：INTRODUCTION:We aimed to identify causes of false-positives in ultrasound scanning of synovial/tenosynovial/bursal inflammation and provide corresponding imaging examples. METHODS:We first performed systematic literature review to identify previously reported causes of false-positives. We next determined causes of fal...

journal_title：Modern rheumatology

authors： Ikeda K,Narita A,Ogasawara M,Ohno S,Kawahito Y,Kawakami A,Ito H,Matsushita I,Suzuki T,Misaki K,Ogura T,Kamishima T,Seto Y,Nakahara R,Kaneko A,Nakamura T,Henmi M,Fukae J,Nishida K,Sumida T,Koike T

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVES:The aims of this study were to clarify the long-term outcome of patients with polymyositis and dermatomyositis (PM/DM) and to elucidate prognostic factors using statistical analysis. METHODS:We enrolled patients with PM/DM who visited our department between 1990 and 2014. Diagnoses of PM/DM and clinically a...

journal_title：Modern rheumatology

authors： Ishizuka M,Watanabe R,Ishii T,Machiyama T,Akita K,Fujita Y,Shirota Y,Fujii H,Harigae H

更新日期：2016-01-01 00:00:00

abstract：:Abstract We evaluated bone mineral density (BMD) in Japanese female patients with systemic lupus erythematosus (SLE) and assessed the influence of the use of glucocorticoids. Lumbar BMD was measured by dual x-ray absorptiometry (DXA) in 60 premenopausal females who previously had been receiving glucocorticoid therapy....

journal_title：Modern rheumatology

authors： Banno S,Matsumoto Y,Naniwa T,Hayami Y,Sugiura Y,Yoshinouchi T,Ueda R

更新日期：2002-12-01 00:00:00

abstract：:Abstract We report on a 24-year-old woman with systemic lupus erythematosus and lupus anticoagulant who developed chronic thrombotic microangiopathic hemolytic anemia. The patient responded well to a combination of plasma exchange and anticoagulant therapy. Changes in the molecular markers for coagulation and fibrinol...

journal_title：Modern rheumatology

authors： Asanuma Y,Suzuki Y,Yasumuro Y,Ichikawa Y

更新日期：2000-12-01 00:00:00

abstract：OBJECTIVES:To investigate CD44 levels in articular cartilage of knee osteoarthritis (OA) and the relationship between CD44 and severity of the disease. METHODS:All 50 cartilage tissues included normal and OA cartilage, and were ascribed to the following four groups on the basis of modified Mankin score: normal, mild l...

journal_title：Modern rheumatology

authors： Zhang FJ,Luo W,Gao SG,Su DZ,Li YS,Zeng C,Lei GH

更新日期：2013-11-01 00:00:00

abstract：OBJECTIVES:To assess the efficacy of tocilizumab (TCZ) monotherapy for the remission induction of microscopic polyangiitis (MPA) in a prospective single-arm, single-center, cohort, pilot study. METHODS:Eligible patients were aged between 20 and 80 years and were newly diagnosed with MPA according to Watts' classificat...

journal_title：Modern rheumatology

authors： Sakai R,Kondo T,Kikuchi J,Shibata A,Chino K,Okuyama A,Takei H,Amano K

更新日期：2016-11-01 00:00:00

abstract：:Adult-onset Still's disease (AOSD) is a rheumatoid disorder characterized by high fever, polyarthritis, leukocytosis, hyperferritinaemia, and mild liver involvement. We describe the case of a patient with AOSD with severe liver dysfunction. His serum levels of interleukin-10 and 18 showed a similar trend to his diseas...

journal_title：Modern rheumatology

authors： Ito T,Ozaki Y,Shimamoto K,Amuro H,Tanijiri T,Yokoi T,Son Y,Tajima K,Fukuhara S

更新日期：2008-01-01 00:00:00

abstract：:To evaluate the efficacy of high-dose leukocytapheresis (LCAP) using a large filter in patients with refractory rheumatoid arthritis (RA), we conducted a multicenter, nonrandomized, open-label clinical study. Thirty patients with highly active RA were treated with high-dose LCAP performed 3-5 sessions at 1-week interv...

journal_title：Modern rheumatology

authors： Eguchi K,Saito K,Kondo M,Hidaka T,Ueki Y,Tanaka Y,LCAP Investigators in Kyushu College of Rheumatology (LIKCR).

更新日期：2007-01-01 00:00:00

abstract：:Objectives: To assess the effects of belimumab on disease activity across multiple organ domains in Japanese patients from the Phase 3 randomized, double-blind, North-East Asia study, BEL113750 (NCT01345253).Methods: Patients, aged ≥18 years, with American College of Rheumatology-defined systemic lupus erythematosus (...

journal_title：Modern rheumatology

authors： Tanaka Y,Bass D,Chu M,Egginton S,Ji B,Roth D

更新日期：2020-03-01 00:00:00

abstract：:Abstract We report a case of hypocalcemic myopathy confounded by polymyositis due to an elevated level of serum creatine kinase (CK). A 30-year-old man was referred to our hospital for the treatment of provisionally diagnosed polymyositis. His presentation with tetany, hyporeflexia, and general fatigue, in addition to...

journal_title：Modern rheumatology

authors： Hirata D,Nagashima T,Saito S,Okazaki H,Kano S,Minota S

更新日期：2002-06-01 00:00:00

abstract：:The objective of this study was to show whether the disease activity of rheumatoid arthritis (RA) patients had improved in Japan, and whether the improvement of disease activity had resulted in a better outcome of patients. In a single-institute-based prospective observational cohort of RA patients (Institute of Rheum...

journal_title：Modern rheumatology

authors： Yamanaka H,Inoue E,Singh G,Tanaka E,Nakajima A,Taniguchi A,Hara M,Tomatsu T,Kamatani N

更新日期：2007-01-01 00:00:00

abstract：OBJECTIVE:This study aimed to evaluate whether the level of serum matrix metalloproteinase-3 (MMP-3), a marker of synovium inflammation, is affected by clinical characteristics of patients in rheumatoid arthritis (RA) patients. METHODS:We analyzed data from 1087 female patients with RA. Pearson's correlation coefficie...

journal_title：Modern rheumatology

authors： Hattori Y,Kida D,Kaneko A

更新日期：2018-03-01 00:00:00

abstract：OBJECTIVE:To evaluate the safety of peficitinib for the treatment of rheumatoid arthritis (RA) in Asian patients. METHODS:Safety data from one Phase 2b, two Phase 3, and one open-label long-term extension study [data cut-off 31 May 2018] were pooled into Phase 3 studies (peficitinib 100 and 150 mg/day, and placebo) an...

journal_title：Modern rheumatology

authors： Takeuchi T,Tanaka Y,Rokuda M,Izutsu H,Kaneko Y,Fukuda M,Kato D

更新日期：2020-11-09 00:00:00

abstract：OBJECTIVES:In recent years, concern has been raised about Juvenile Idiopathic Arthritis (JIA) that it could be associated with an increased risk for malignancies. Therefore, the cancer incidence in the JIA patients was evaluated and compared to the cancer incidence in the German population. METHODS:A retrospective sin...

journal_title：Modern rheumatology

authors： Barth S,Schlichtiger J,Hartmann B,Bisdorff B,Michels H,Radon K,Hügle B,Walsh L,Haas JP

更新日期：2017-01-01 00:00:00

abstract：:We evaluated the prevalence of Helicobacter pylori infection and the association of H. pylori infection and/or nonsteroidal anti-inflammatory drug (NSAID) use with upper gastrointestinal (UGI) ulcers in a cohort of Japanese patients with rheumatoid arthritis (RA). Using the clinical database of the cohort of RA patien...

journal_title：Modern rheumatology

authors： Tanaka E,Singh G,Saito A,Syouji A,Yamada T,Urano W,Nakajima A,Taniguchi A,Tomatsu T,Hara M,Saito T,Kamatani N,Yamanaka H

更新日期：2005-01-01 00:00:00

abstract：:A 68-year-old Japanese male presented with atrophic erythematous white lesions with peripheral dark reddish rims on his back. Multiple ulcers were detected from his stomach to his large intestine using endoscopy. Although the patient was given high doses of a steroid, aspirin, dipyridamole, and intravenous immunoglobu...

journal_title：Modern rheumatology

authors： Umemura M,Miwa Y,Yanai R,Isojima S,Tokunaga T,Tsukamoto H,Takahashi R,Yajima N,Kasama T,Takahashi N,Sueki H,Yamaguchi S,Arai K,Takeuchi Y,Ohike N,Norose T,Yamochi-Onizuka T,Takimoto M

更新日期：2015-05-01 00:00:00

abstract：:Management of rheumatoid arthritis (RA) has improved over the last 10 years. These changes have been monitored in the Institute of Rheumatology, Rheumatoid Arthritis (IORRA) observational cohort, and clinical remission has become a realistic goal. However, we should recognize that the ultimate goal of treatment is to ...

journal_title：Modern rheumatology

authors： Yamanaka H,Seto Y,Tanaka E,Furuya T,Nakajima A,Ikari K,Taniguchi A,Momohara S

更新日期：2013-01-01 00:00:00

abstract：:Abstract  This study examined the pathogenesis of large pseudocysts adjacent to knee joints in rheumatoid arthritis (RA). The radiological and histopathological features of 17 large subarticular pseudocysts in 12 knee joints of 10 patients were analyzed. Nine of the 10 patients were classified as class 2 according to ...

journal_title：Modern rheumatology

authors： Yoshida M,Ichinohe S,Uzuki M,Yoshida W,Sawai T,Shimamura T

更新日期：2002-06-01 00:00:00

abstract：:Peripheral neuropathies should be recognized as the adverse effects of biological agents, especially anti-TNF agents. However, no solid clinical databases for biological agent-associated peripheral neuropathies (BAPN) have been established in Japan. Here we report two cases of peripheral neuropathy associated with ant...

journal_title：Modern rheumatology

authors： Yagita M,Hamano T,Hatachi S,Fujita M

更新日期：2016-01-01 00:00:00

abstract：:We report a case of acute generalized pustular bacterid (AGPB) concomitant with erythema nodosum (EN), polyarthritis, and Achilles tendinitis. The patient was admitted with a complaint of fever, widespread plural pustules, erythema, and polyarthralgia. Histopathological examination of the skin lesions demonstrated fea...

journal_title：Modern rheumatology

authors： Arita Y,Taguchi H,Hanada R,Tono T,Ohsone Y,Okata U,Irie R,Okano Y

更新日期：2019-01-01 00:00:00

abstract：:Macrophage activation syndrome (MAS), also known as secondary hemophagocytic lymphohistiocytosis, is mediated by cytokine overproduction from excessive activation of T lymphocytes and macrophages. We present a dermatomyositis patient with MAS, caused by hypercytokinemia. The combination of tacrolimus and plasma exchan...

journal_title：Modern rheumatology

authors： Kaieda S,Yoshida N,Yamashita F,Okamoto M,Ida H,Hoshino T,Fukuda T

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVES:To determine the frequency of Th2-mediated allergic diseases (AD) in mainly Th1-driven juvenile idiopathic arthritis (JIA) subtypes. METHODS:Ninety-nine JIA patients and 128 control subjects were enrolled in a prospective case-control study. All subjects were assessed with standard allergy questionnaire, co...

journal_title：Modern rheumatology

authors： Avar-Aydin PO,Nepesov S,Barut K,Sahin S,Adrovic A,Cokugras HC,Kasapcopur O

更新日期：2020-09-07 00:00:00

abstract：OBJECTIVES:The purpose of the present study was to describe our experience with the recombinant Fab' antibody fragment against TNF-α Certolizumab Pegol (CZP) in patients with Behçet's disease (BD) refractory to standardized therapies and previous biologic agents. METHODS:Retrieved data including demographic characteri...

journal_title：Modern rheumatology

authors： Lopalco G,Emmi G,Gentileschi S,Guerriero S,Vitale A,Silvestri E,Becatti M,Cavallo I,Fabiani C,Frediani B,Iannone F,Cantarini L

更新日期：2017-11-01 00:00:00

abstract：OBJECTIVE:Upper limit of methotrexate (MTX) for patients with rheumatoid arthritis (RA) was recently increased from 8 to 16 mg/week in Japan. We therefore examined the effect of concomitant MTX dose on the efficacy of adalimumab (ADA) in clinical practice. METHOD:Sixty-one consecutive RA patients treated with ADA were...

journal_title：Modern rheumatology

authors： Nakashima Y,Miyahara H,Kondo M,Fukuda T,Harada H,Haraguchi A,Inoue Y,Ishinishi T,Maekawa M,Maeyama A,Nakashima M,Shono E,Suematsu E,Shimauchi T,Tsuru T,Tsukamoto H,Yoshizawa S,Yoshizawa S,Iwamoto Y

更新日期：2017-01-01 00:00:00

abstract：OBJECTIVE:The prediction of hip osteoarthritis (OA) progression is still a difficult issue. We have adopted (18)F-fluoride positron emission tomography (PET) for the evaluation of hip osteoarthritis, and investigated the prediction utility of (18)F-fluoride PET for both pain worsening and OA progression using a logisti...

journal_title：Modern rheumatology

authors： Kobayashi N,Inaba Y,Yukizawa Y,Ike H,Kubota S,Inoue T,Saito T

更新日期：2015-01-01 00:00:00

abstract：:Objectives: In this study, we aimed to evaluate the level of central sensitization (CS) and its relationship with health profile, including neuropathic pain and sleep quality in Behçet's disease (BD).Method: Eighty-eight patients with BD and 60 healthy controls (HCs) were included in the study between May 2018 and Feb...

journal_title：Modern rheumatology

authors： Ayar K,Ökmen BM,Altan L,Öztürk EK

更新日期：2020-07-06 00:00:00