Abstract:
OBJECTIVES:The purpose of the present study was to describe our experience with the recombinant Fab' antibody fragment against TNF-α Certolizumab Pegol (CZP) in patients with Behçet's disease (BD) refractory to standardized therapies and previous biologic agents. METHODS:Retrieved data including demographic characteristics, clinical manifestations, and previous treatments were collected in three different specialized Rheumatologic Units in Italy. In order to evaluate disease activity, the BD current activity form (BDCAF) has been used before starting CZP therapy and at each visit during treatment. RESULTS:Thirteen BD patients (mean age 42.6 ± 8.8 years) with a disease duration of 8.80 ± 6.9 years, underwent CZP treatment for 6.92 ± 3.52 months. Six patients (46.15%) experienced a worsening of symptoms after 4.16 ± 1.21 months, whereas a satisfactory response was achieved in seven patients (53.84%) who were still on CZP therapy at the last follow-up visit (after 9.28 ± 3.03 months of treatment). The mean decrease of BDCAF between the first and last visit was 0.308 ± 1.84 without reaching significant difference (mean 8.3 ± 1.3 and 8 ± 2.08, respectively; p= .51). During the whole study period, CZP was well tolerated in all patients except one who developed a generalized cutaneous reaction after the third administration. CONCLUSIONS:These results suggest that despite an improvement of clinical manifestations has been observed in more than half of the patients, it is not possible to draw firm conclusions about the effectiveness of CZP in BD and further studies with larger cohorts of patients are warranted. Whether the increase of CZP dosage may ensure a better clinical response remains an unsolved issue that needs to be considered.
journal_name
Mod Rheumatoljournal_title
Modern rheumatologyauthors
Lopalco G,Emmi G,Gentileschi S,Guerriero S,Vitale A,Silvestri E,Becatti M,Cavallo I,Fabiani C,Frediani B,Iannone F,Cantarini Ldoi
10.1080/14397595.2017.1285857subject
Has Abstractpub_date
2017-11-01 00:00:00pages
1031-1035issue
6eissn
1439-7595issn
1439-7609journal_volume
27pub_type
杂志文章,多中心研究abstract:OBJECTIVE:To retrospectively evaluate whether oral glucocorticoid (GC) administration can be tapered or discontinued over a 2-year observation period in patients with rheumatoid arthritis (RA) undergoing a stable oral GC treatment, without deterioration in the disease status. METHODS:Methotrexate (MTX) and prednisolon...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2020.1864914
更新日期:2020-12-16 00:00:00
abstract::Abstract To determine the specificities of autoantibodies targeting cell cycle-associated antigens in rheumatic diseases, we studied 30 sera which were obtained from patients visiting our hospital and which exhibited a variegated speckled pattern in indirect immunofluorescence (IF). The immunoreactivities of the sera ...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/s101650170008
更新日期:2001-09-01 00:00:00
abstract::Rheumatoid arthritis (RA) is a complex process of chronic and progressive inflammation associated with activation of numerous signaling molecules and transcription factors and hyperproliferation of synoviocytes of the affected joints, although the greater part of its pathophysiological process is explained by activati...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-004-0372-8
更新日期:2005-01-01 00:00:00
abstract::The expression of CD25 or CD28 on T cells was examined in patients with rheumatic diseases associated with interstitial pneumonitis (IP), in order to investigate the conditions of CD4+CD25+ regulatory T cells and CD8+CD28- suppressor T cells. Fifty-five patients with various rheumatic diseases and 23 normal controls w...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-008-0090-8
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVES:To determine the availability of bioelectrical impedance analysis (BIA), computed tomography (CT), and magnetic resonance imaging (MRI) for measurement of skeletal muscle mass in patients with rheumatic diseases and quantitatively assess skeletal muscle loss after glucocorticoid (GC) treatment. METHODS:The ...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2014.935078
更新日期:2015-03-01 00:00:00
abstract::Inflammation has often been considered to be a nonspecific response and to play a bridging role in the activation of adaptive immunity. However, it is now accepted that inflammation is the product of an independent innate immune system closely linked to the adaptive immune system. The key mediators of inflammation are...
journal_title:Modern rheumatology
pub_type: 杂志文章,评审
doi:10.3109/14397595.2014.902747
更新日期:2015-01-01 00:00:00
abstract::A 61-year-old woman was admitted for long-lasting fever and recurrent opportunistic infections during the treatment of SLE. She had been diagnosed as SLE and type-IV nephritis based on a renal biopsy and serological findings. A colonoscopy and liver biopsy revealed disseminated Mycobacterium avium complex infection. H...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2014.997822
更新日期:2017-05-01 00:00:00
abstract::We performed total hip arthroplasty using the non-cement impaction auto-bone-grafting method with the resected femoral head for acetabular protrusion that is not combined with the destruction of acetabular rim or dysplasia of the hip joint. Ten patients (eight women and two men) with rheumatoid arthritis who showed ac...
journal_title:Modern rheumatology
pub_type: 临床试验,杂志文章
doi:10.1007/s10165-007-0571-1
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVES:Lupus enteritis (LE) is a rare but well-known gastrointestinal manifestation of systemic lupus erythematosus (SLE). This study was conducted to identify prognostic factors associated with poor responses in patients with LE. METHODS:We consecutively registered patients diagnosed with LE between January 2009 ...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2020.1812871
更新日期:2020-09-07 00:00:00
abstract::We report a novel case of eosinophilic orbital myositis associated with Churg-Strauss syndrome. A 56-year-old man with a 20-year history of chronic sinusitis and seasonal allergic rhinitis was admitted because of fever, swelling of cheeks and extremities, diplopia, and eosinophilia. With findings from gadolinium-enhan...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-009-0252-3
更新日期:2010-04-01 00:00:00
abstract::One of the severe adverse effects of intra-articular injection in the knee is septic arthritis of the knee joint. Staphylococcus aureus is the most frequent pathogen of septic arthritis. Staphylococcal scalded skin syndrome (SSSS) refers to a spectrum of blistering skin diseases caused by S. aureus exfoliative toxins....
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-010-0391-6
更新日期:2011-06-01 00:00:00
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journal_title:Modern rheumatology
pub_type: 杂志文章,多中心研究
doi:10.1080/14397595.2018.1486939
更新日期:2019-07-01 00:00:00
abstract::Bucillamine (Buc) is a disease-modifying antirheumatic drug (DMARD) developed in Japan, which has been used as one of the first-line DMARDs for the treatment of rheumatoid arthritis (RA) in Japan. However, direct comparison of this drug with standard DMARDs including sulfasalazine (SASP) and methotrexate (MTX) has bee...
journal_title:Modern rheumatology
pub_type: 临床试验,杂志文章
doi:10.1007/s10165-006-0527-x
更新日期:2006-01-01 00:00:00
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journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/s10165-004-0314-5
更新日期:2004-09-01 00:00:00
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journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-009-0266-x
更新日期:2010-06-01 00:00:00
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journal_title:Modern rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10165-012-0702-1
更新日期:2013-01-01 00:00:00
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journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-006-0462-x
更新日期:2006-01-01 00:00:00
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journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-012-0720-z
更新日期:2013-07-01 00:00:00
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journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-005-0430-x
更新日期:2005-01-01 00:00:00
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journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2020.1804668
更新日期:2020-09-03 00:00:00
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journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2015.1070446
更新日期:2016-01-01 00:00:00
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journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2019.1660027
更新日期:2020-09-01 00:00:00
abstract::Anti-tumor necrosis factor (anti-TNF) biologics are effective in the treatment of rheumatoid arthritis (RA); however, it is still not clear whether this treatment promotes the development of malignancies such as lymphoma. Human T-lymphotropic virus type 1 (HTLV-1), which is a causative agent of adult T-cell lymphoma (...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2013.844389
更新日期:2015-09-01 00:00:00
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journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2016.1218596
更新日期:2019-03-01 00:00:00
abstract::The chondrocytes of cartilage have so far been reported to include three mechanoresponsive genes: cartilage matrix protein (CMP, matrilin-1), type X collagen, and Indian hedgehog (Ihh). In fact, all of the genes identified in these chondrocytes are associated solely with mechanical stress. In this study we examined th...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-006-0469-3
更新日期:2006-01-01 00:00:00
abstract:OBJECTIVES:To evaluate the scoring of whole-body magnetic resonance imaging (WBMRI) for efficacy assessment in rheumatoid arthritis (RA) patients receiving biological disease-modifying anti-rheumatic drugs (bDMARDs). METHODS:Thirty consecutive RA patients receiving bDMARDs were included in this retrospective study. Co...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2016.1276425
更新日期:2017-11-01 00:00:00
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journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2018.1510879
更新日期:2019-09-01 00:00:00
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journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/s101650200022
更新日期:2002-06-01 00:00:00
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journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/s101650200032
更新日期:2002-06-01 00:00:00
abstract::A 10-year cohort study was performed, involving all of the 118 patients treated with bucillamine in our hospital between 1988 and 1990. Evaluation was made on the basis of erythrocyte sedimentation rate, grip strength, joint score, duration of morning stiffness, and Lansbury index consisting of the above four paramete...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-006-0533-z
更新日期:2007-01-01 00:00:00