Nonthrombotic proliferative vasculopathy associated with antiphospholipid antibodies: A case report and literature review.

Abstract:

:A 20-year-old man presented with recurrent hemoptysis for seven months. A small subpleural nodule in his right lower lobe was found and excised surgically. Based on the presence of antiphospholipid antibodies (aPL) and vascular wall hypertrophy without vasculitis or an intraluminal thrombus, nonthrombotic proliferative vasculopathy (NTPV) affecting pulmonary arteries was diagnosed. Recently, aPL have been postulated to directly induce the proliferation of vascular cells in the intima and media, leading to NTPV. We review 5 cases of NTPV-associated aPL with critical ischemia in the lower extremities and gastrointestinal infarction. NTPV-associated aPL might be distinct from classic antiphospholipid syndrome and should be considered in aPL-positive patients who present with vascular occlusions of medium-sized vessels in the absence of atherosclerotic risk factors and systemic or local inflammation.

journal_name

Mod Rheumatol

journal_title

Modern rheumatology

authors

Lee JS,Kim H,Lee EB,Song YW,Park JK

doi

10.1080/14397595.2016.1218596

subject

Has Abstract

pub_date

2019-03-01 00:00:00

pages

388-392

issue

2

eissn

1439-7595

issn

1439-7609

journal_volume

29

pub_type

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