Thrombotic microangiopathic hemolytic anemia in systemic lupus erythematosus associated with antiphospholipid antibodies: usefulness of monitoring coagulation-fibrinolysis markers.

abstract：:Abstract An accumulating body of evidence shows that gene therapy can be successfully used to treat animal models of arthritis. Based on this success, a clinical trial of gene therapy for rheumatoid arthritis has been initiated. We review the methods and genes used for the previous gene transfer experiments, including...

journal_title：Modern rheumatology

authors： Kohsaka H

更新日期：2000-06-01 00:00:00

abstract：:Risk of knee osteoarthritis (OA) was assessed in a population-based case-control study of Japanese men. The study covered three health districts in Wakayama and Osaka prefectures, Japan. Subjects were male individuals >or=45 years old diagnosed radiographically with knee OA, and who did not display any established cau...

journal_title：Modern rheumatology

authors： Yoshimura N,Kinoshita H,Hori N,Nishioka T,Ryujin M,Mantani Y,Miyake M,Takeshita T,Ichinose M,Yoshiida M,Oka H,Kawaguchi H,Nakamura K,Cooper C

更新日期：2006-01-01 00:00:00

abstract：:A female rheumatoid arthritis patient was admitted for productive cough and general fatigue that had gradually developed after leflunomide therapy. Side effects including severe hypoxia, thrombocytopenia, lymphocytopenia, and macrocytic anemia with schistocytes (probably drug-induced megaloblastic anemia) were noted. ...

journal_title：Modern rheumatology

authors： Toyokawa Y,Kingetsu I,Yasuda C,Yasuda J,Yoshida K,Kurosaka D,Yamada A

更新日期：2007-01-01 00:00:00

abstract：:Research into the bone destruction associated with rheumatoid arthritis has highlighted the importance of the interplay of the immune and skeletal systems. Arthritic bone destruction is attributable to the defective control of osteoclastogenesis by T cells. We revealed that excessive expression of receptor activator o...

journal_title：Modern rheumatology

authors： Takayanagi H

更新日期：2005-01-01 00:00:00

abstract：:Clinical squeal of the treatment of rheumatoid arthritis patients with methotrexate (MTX) according to the Japanese government recommended dose of 8 mg/week was evaluated prospectively. A total of 176 patients with active RA attending Konan Kakogawa Hospital and Kobe University Hospital were enrolled. Patients' profil...

journal_title：Modern rheumatology

authors： Hashiramoto A,Shiozawa K,Tanaka Y,Yamane T,Murata M,Tanaka C,Terashima Y,Koyama K,Nakagawa N,Abe S,Yoshihara R,Saegusa Y,Tsumiyama K,Komai K,Sakai Y,Shiozawa S

更新日期：2009-01-01 00:00:00

abstract：OBJECTIVE:We seek to evaluate the opinions of nurses and doctors in Japan regarding EULAR recommendations for nurses' roles in the management of chronic inflammatory arthritis. METHODS:This is a cross-sectional survey within Japan. We randomly selected nurses and doctors engaged in consultation of patients with rheuma...

journal_title：Modern rheumatology

authors： Fusama M,Nakahara H,van Eijk-Hustings Y,Oliver S,Takeuchi T

更新日期：2017-09-01 00:00:00

abstract：:We describe an 81-year-old man with immunoglobulin G4-related disease (IgG4-RD) presenting with submandibular gland, lymph node, lung, kidney, aortic wall, and prostate lesions with concomitant gastric cancer. After curative surgical treatment of the gastric cancer, corticosteroid therapy for progressively decreasing ...

journal_title：Modern rheumatology

authors： Horita S,Fujii H,Mizushima I,Fujisawa Y,Hara S,Yamada K,Inoue D,Nakajima K,Harada K,Kawano M

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:Colchicine is the mainstay of the treatment of familial Mediterranean fever (FMF). However, 10% of FMF patients do not respond well to colchicine. Efficacy of interleukin (IL)-1 inhibitors in reducing attacks have been demonstrated in colchicine-resistant FMF (crFMF) patients recently. Colchicine is still th...

journal_title：Modern rheumatology

authors： Varan Ö,Kucuk H,Babaoglu H,Guven SC,Ozturk MA,Haznedaroglu S,Goker B,Tufan A

更新日期：2019-03-01 00:00:00

abstract：OBJECTIVE:The international classification criteria (CC) for definite antiphospholipid syndrome (APS) recommend confirmation of the sustained presence, for at least 12 weeks, of both lupus anticoagulant (LA), as determined by aPTT and RVVT, and anti β2glycoprotein I (β2GPI) or anticardiolipin (aCL) IgG and/or IgM. Howe...

journal_title：Modern rheumatology

authors： Sugiura-Ogasawara M,Atsumi T,Yamada H,Kitaori T,Ozaki Y,Katano K,Murashima A

更新日期：2015-01-01 00:00:00

abstract：:To investigate the precise modality of association between SAA1 gene polymorphisms and the development of AA amyloidosis in patients with rheumatoid arthritis (RA), Japanese patients with RA (n=153), among whom 29 were histologically diagnosed as having amyloidosis, were genotyped for three single nucleotide polymorph...

journal_title：Modern rheumatology

authors： Ajiro J,Narita I,Sato F,Saga D,Hasegawa H,Kuroda T,Nakano M,Gejyo F

更新日期：2006-01-01 00:00:00

abstract：:We report a case of a 60-year-old female with cutaneous polyarteritis nodosa (CPN) of the left ankle, accompanied by elevated serum interleukin (IL)-6 levels. Computed tomographic angiography revealed severe narrowing of medium-sized arteries in her left leg. Destructive arthropathy in the left ankle was identified by...

journal_title：Modern rheumatology

authors： Horai Y,Tokuyama A,Sumiyoshi R,Nakashima Y,Suzuki T,Okada A,Kawashiri SY,Ichinose K,Izumi Y,Miyashita T,Tamai M,Yamasaki S,Nakamura H,Hayashi T,Origuchi T,Kawakami A

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVES:The characteristics of lymphoproliferative disorders (LPD) in patients with rheumatoid arthritis (RA) remain unclear. Therefore, we retrospectively analyzed the clinical characteristics of these patients in our department. METHODS:Twenty RA patients who developed LPD between April 2003 and August 2016 in ou...

journal_title：Modern rheumatology

authors： Tsukui D,Kanda H,Shinozaki-Ushiku A,Tateishi S,Takeshima Y,Nagafuchi Y,Sasaki O,Iwasaki Y,Harada H,Shibuya M,Sumitomo S,Shoda H,Kubo K,Fujio K,Nakamura F,Kurokawa M,Fukayama M,Yamamoto K

更新日期：2018-07-01 00:00:00

abstract：:The aim of our study was to determine the spectrum of the 12 most common familial Mediterranean fever gene (MEFV) mutations in Iranian patients with heterogeneous ethnicity, using the familial Mediterranean fever (FMF) strip assay test. A total of 36 patients were diagnosed according to established clinical criteria. ...

journal_title：Modern rheumatology

authors： Bidari A,Ghavidel-Parsa B,Najmabadi H,Talachian E,Haghighat-Shoar M,Broumand B,Ghalehbaghi B

更新日期：2010-12-01 00:00:00

abstract：OBJECTIVE:Fractalkine (CX3CL1/FKN) is a chemokine that regulates chemotaxis and adhesion of CX3C chemokine receptor 1 (CX3CR1)-expressing inflammatory cells. We conducted the first phase 1/2, open-label, multiple ascending dose study of E6011, a humanized anti-FKN monoclonal antibody, in Japanese rheumatoid arthritis (...

journal_title：Modern rheumatology

authors： Tanaka Y,Takeuchi T,Umehara H,Nanki T,Yasuda N,Tago F,Kawakubo M,Kitahara Y,Hojo S,Kawano T,Imai T

更新日期：2018-01-01 00:00:00

abstract：:Abstract Twenty-six patients with systemic lupus erythematosus (SLE) showing systemic lupus activity measure (SLAM) and SLE disease activity index (SLEDAI) scores ≤2, as well as a lower C4 concentration than the mean C4 levels of healthy controls, were selected to evaluate the C4 levels of SLE patients in remission. S...

journal_title：Modern rheumatology

authors： Yasuda M,Suenaga Y,Nishimukai H,Nobunaga M

更新日期：2002-09-01 00:00:00

abstract：OBJECTIVE:We examined the prevalence and risk factors of vertebral fracture in female Japanese patients with systemic lupus erythematosus (SLE). METHODS:We performed lateral radiographs of the thoracic and lumbar spine and bone mineral density (BMD) measurements and collected demographic, lifestyle, clinical, and trea...

journal_title：Modern rheumatology

authors： Furukawa M,Kiyohara C,Horiuchi T,Tsukamoto H,Mitoma H,Kimoto Y,Uchino A,Nakagawa M,Oryoji K,Shimoda T,Harada M,Akashi K

更新日期：2013-07-01 00:00:00

abstract：OBJECTIVES:We investigated the relationship between morphological features in the lower limbs and the progression of knee osteoarthritis (OA) in 6-years. METHODS:Volunteer subjects from Toei (101 women and 54 men). Knee OA was evaluated on whole-leg radiographs. Subjects were divided into group 1, no knee OA; group 2,...

journal_title：Modern rheumatology

authors： Tran DH,Hoshino H,Matsuyama Y

更新日期：2020-09-03 00:00:00

abstract：BACKGROUND:Efficacy of anti-tumor necrosis factor (anti-TNF)α treatment in patient with active ankylosing spondylitis (AS) had been proved by many clinical studies. Inflammation and new bone formation in spine were two pivotal aspects in AS. TNF α inhibitor could eliminate inflammation including clinical and laboratory...

journal_title：Modern rheumatology

authors： Zong HX,Xu SQ,Tong H,Wang XR,Pan MJ,Teng YZ

更新日期：2019-05-01 00:00:00

abstract：:We investigated the association between cigarette smoking and the risk of developing rheumatoid arthritis (RA) in the Malaysian population. A total of 1,056 RA patients and 1,416 matched controls aged 18-70 years within a defined area of Peninsular Malaysia were evaluated in a case-control study between August 2005 an...

journal_title：Modern rheumatology

authors： Yahya A,Bengtsson C,Lai TC,Larsson PT,Mustafa AN,Abdullah NA,Muhamad N,Hussein H,Klareskog L,Alfredsson L,Murad S

更新日期：2012-08-01 00:00:00

abstract：:A 43-year-old Japanese woman with systemic lupus erythematosus (SLE) developed rapidly progressive renal failure and nephritic syndrome with a high titer of myeloperoxidase-antineutrophil cytoplasmic antibody (MPO-ANCA). Methylprednisolone pulse therapy did not suppress the progression of renal failure. Intravenous cy...

journal_title：Modern rheumatology

authors： Morimoto S,Watanabe T,Lee S,Amano H,Kanamaru Y,Ohsawa I,Tomino Y,Takasaki Y

更新日期：2010-06-01 00:00:00

abstract：:We examined the efficacy and safety of autologous transplantation of bone-marrow-derived cells in patients with intractable ulcers caused by systemic sclerosis. Eight patients with ulcers resistant to treatment were enrolled. Bone marrow cells were gathered from the bilateral iliac crests with multiple repositioning b...

journal_title：Modern rheumatology

authors： Ishigatsubo Y,Ihata A,Kobayashi H,Hama M,Kirino Y,Ueda A,Takeno M,Shirai A,Ohno S

更新日期：2010-06-01 00:00:00

abstract：OBJECTIVES:To understand the status of mizoribine use in patients with lupus nephritis (LN) and to collect safety- and efficacy-related data on 2-year treatment with mizoribine. METHODS:A continuous survey was conducted between March 2010 and July 2015. RESULTS:The analysis set included 559 patients (mean age 39.5 ye...

journal_title：Modern rheumatology

authors： Takeuchi T,Okada K,Yoshida H,Yagi N

更新日期：2018-01-01 00:00:00

abstract：OBJECTIVES:Our primary objective was to retrospectively analyze whether bisphosphonates initiated in combination with immunosuppressive drugs and/or intravenous immunoglobulin (IVIG) resulted in a radiological and clinical improvement of dystrophic calcinosis in six female juvenile dermatomyositis (JDM) patients. METH...

journal_title：Modern rheumatology

authors： Tayfur AC,Topaloglu R,Gulhan B,Bilginer Y

更新日期：2015-07-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a multisystem autoimmune connective-tissue disease with a complex phenotype and varying disease course. Although SLE often causes a polyarticular synovitis, there are only a few case reports of abnormalities of the synovial lined sacroiliac joints. We report a case with an overlap...

journal_title：Modern rheumatology

authors： Chandrasekhara PK,Jayachandran NV,Thomas J,Narsimulu G

更新日期：2009-01-01 00:00:00

abstract：OBJECTIVES:Pathogenesis and risk factors of scleroderma associated calcinosis is poorly understood and there is no effective treatment. This study was performed to better understand the prevalence and clinical features associated with calcinosis in a cohort of SSc outpatients. METHODS:In this cross-sectional study, we...

journal_title：Modern rheumatology

authors： Pai S,Hsu V

更新日期：2018-05-01 00:00:00

abstract：:Tumor necrosis factor (TNF) plays an important role in the host defense mechanism, and anti-TNF antibody therapies may increase the risk of serious infections. We herein report a case of 57-year-old male with rheumatoid arthritis who developed brucellosis during treatment with infliximab in combination with methotrexa...

journal_title：Modern rheumatology

authors： Akgul O,Ozgocmen S

更新日期：2011-06-01 00:00:00

abstract：OBJECTIVE:The prediction of hip osteoarthritis (OA) progression is still a difficult issue. We have adopted (18)F-fluoride positron emission tomography (PET) for the evaluation of hip osteoarthritis, and investigated the prediction utility of (18)F-fluoride PET for both pain worsening and OA progression using a logisti...

journal_title：Modern rheumatology

authors： Kobayashi N,Inaba Y,Yukizawa Y,Ike H,Kubota S,Inoue T,Saito T

更新日期：2015-01-01 00:00:00

abstract：:A 79-year-old man was diagnosed with relapsing polychondritis, from symptoms of bilateral auricular deformity and pigmentation, polyarthralgia, and audiovestibular damage, and from histological examination of the left auricular cartilage. The left auricular cartilage biopsy specimen revealed cartilage destruction with...

journal_title：Modern rheumatology

authors： Horai Y,Miyamura T,Arase H,Kimura D,Shimada K,Ishida M,Takahama S,Kiyasu J,Minami R,Yamamoto M,Suematsu E,Nakayama Y

更新日期：2011-10-01 00:00:00

abstract：OBJECTIVES:To investigate CD44 levels in articular cartilage of knee osteoarthritis (OA) and the relationship between CD44 and severity of the disease. METHODS:All 50 cartilage tissues included normal and OA cartilage, and were ascribed to the following four groups on the basis of modified Mankin score: normal, mild l...

journal_title：Modern rheumatology

authors： Zhang FJ,Luo W,Gao SG,Su DZ,Li YS,Zeng C,Lei GH

更新日期：2013-11-01 00:00:00

abstract：:Abstract A woman with Sjögren's syndrome concurrently suffered bilateral fractures of the femoral neck without any proximate cause, while she had aseptic necrosis of the femoral head resulting from the treatment for Sjögren's syndrome. According to previous reports, fractures of the femoral neck following aseptic necr...

journal_title：Modern rheumatology

authors： Kamiya M,Ueno M,Yamaguchi H,Kanata S,Sohen S

更新日期：2004-12-01 00:00:00