A case of pure red cell aplasia complicated by Evans syndrome.

abstract：OBJECTIVE:The prediction of hip osteoarthritis (OA) progression is still a difficult issue. We have adopted (18)F-fluoride positron emission tomography (PET) for the evaluation of hip osteoarthritis, and investigated the prediction utility of (18)F-fluoride PET for both pain worsening and OA progression using a logisti...

journal_title：Modern rheumatology

authors： Kobayashi N,Inaba Y,Yukizawa Y,Ike H,Kubota S,Inoue T,Saito T

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVE:Fractalkine (CX3CL1/FKN) is a chemokine that regulates chemotaxis and adhesion of CX3C chemokine receptor 1 (CX3CR1)-expressing inflammatory cells. We conducted the first phase 1/2, open-label, multiple ascending dose study of E6011, a humanized anti-FKN monoclonal antibody, in Japanese rheumatoid arthritis (...

journal_title：Modern rheumatology

authors： Tanaka Y,Takeuchi T,Umehara H,Nanki T,Yasuda N,Tago F,Kawakubo M,Kitahara Y,Hojo S,Kawano T,Imai T

更新日期：2018-01-01 00:00:00

abstract：OBJECTIVES:Locomotive syndrome (LS) encompasses conditions that may lead to the need for nursing services. We aimed to quantify the association between exercise habits during youth or the middle-age years and both physical function and the presence of LS in Japanese elderly people. METHODS:We examined 460 participants...

journal_title：Modern rheumatology

authors： Nishimura A,Ito N,Asanuma K,Akeda K,Ogura T,Sudo A

更新日期：2018-03-01 00:00:00

abstract：:Aortitis, inflammation of the aortic tissue, is most commonly caused by vasculitic rheumatic conditions, and less frequently infectious organisms. Involvement of the aorta is well defined in HLA-B27-associated spondyloarthropathies such as long-standing ankylosing spondylitis and Reiter's syndrome. However, unlike oth...

journal_title：Modern rheumatology

authors： Tufan A,Engin Tezcan M,Kaya A,Mercan R,Oner Y,Ozturk MA

更新日期：2012-09-01 00:00:00

abstract：OBJECTIVES:A multicenter, randomized, double-blind, placebo-controlled study of the oral calcineurin inhibitor tacrolimus was performed in patients with early rheumatoid arthritis who had responded poorly to disease-modifying antirheumatic drugs (DMARDs), and factors related to suppression of joint destruction were inv...

journal_title：Modern rheumatology

authors： Tanaka Y,Kawai S,Takeuchi T,Yamamoto K,Miyasaka N

更新日期：2013-11-01 00:00:00

abstract：:Periaortitis and periarteritis are one of the clinical features of IgG4-related disease. Such vascular manifestations are reported to be present in 10-30% of overall IgG4-related disease, and they may also appear as an isolated lesion of IgG4-related disease. As other types of large vessel vasculitis, IgG4-related vas...

journal_title：Modern rheumatology

authors： Mizushima I,Kasashima S,Fujinaga Y,Kawano M,Ishizaka N

更新日期：2019-03-01 00:00:00

abstract：OBJECTIVES:The purpose of the present study was to describe our experience with the recombinant Fab' antibody fragment against TNF-α Certolizumab Pegol (CZP) in patients with Behçet's disease (BD) refractory to standardized therapies and previous biologic agents. METHODS:Retrieved data including demographic characteri...

journal_title：Modern rheumatology

authors： Lopalco G,Emmi G,Gentileschi S,Guerriero S,Vitale A,Silvestri E,Becatti M,Cavallo I,Fabiani C,Frediani B,Iannone F,Cantarini L

更新日期：2017-11-01 00:00:00

abstract：OBJECTIVES:Lupus enteritis (LE) is a rare but well-known gastrointestinal manifestation of systemic lupus erythematosus (SLE). This study was conducted to identify prognostic factors associated with poor responses in patients with LE. METHODS:We consecutively registered patients diagnosed with LE between January 2009 ...

journal_title：Modern rheumatology

authors： Yoshida Y,Omoto T,Kohno H,Tokunaga T,Kuranobu T,Yukawa K,Watanabe H,Oi K,Sugimoto T,Mokuda S,Nojima T,Hirata S,Sugiyama E

更新日期：2020-09-07 00:00:00

abstract：:The aim of our study was to determine the spectrum of the 12 most common familial Mediterranean fever gene (MEFV) mutations in Iranian patients with heterogeneous ethnicity, using the familial Mediterranean fever (FMF) strip assay test. A total of 36 patients were diagnosed according to established clinical criteria. ...

journal_title：Modern rheumatology

authors： Bidari A,Ghavidel-Parsa B,Najmabadi H,Talachian E,Haghighat-Shoar M,Broumand B,Ghalehbaghi B

更新日期：2010-12-01 00:00:00

abstract：:Abstract We report a rare case of a 17-year-old female with overlap syndrome (systemic lupus erythematosus and systemic sclerosis) who developed severe abdominal pain and bloody diarrhea accompanied by central nervous system lupus. Colonoscopy revealed multiple irregular and linear ulcers throughout the colon, which w...

journal_title：Modern rheumatology

authors： Ota Y,Nozue N,Dei Y,Kondo S,Ohashi H

更新日期：2003-12-01 00:00:00

abstract：OBJECTIVE:Increased femoral neck bone mineral density (BMD) in a hip with osteoarthritis (OA) has been previously reported, however, it is possible that increased BMD at sites other than the hip joint is influenced by the disease process of OA. Therefore, we measured BMD at locations different from the hip joint and de...

journal_title：Modern rheumatology

authors： Okano K,Ito M,Aoyagi K,Osaki M,Enomoto H,Yamaguchi K

更新日期：2014-03-01 00:00:00

abstract：:Hyperimmunoglobulin E syndrome (HIES) is a primary immunodeficiency disorder with multisystem abnormalities including the vascular system. We report a child with autosomal recessive (AR)-HIES secondary to dedicator of cytokinesis 8 (DOCK8) deficiency who developed critical aortic aneurysm involving the ascending aorta...

journal_title：Modern rheumatology

authors： Al Mutairi M,Al-Mousa H,AlSaud B,Hawwari A,AlJoufan M,AlWesaibi A,AlHalees Z,Al-Mayouf SM

更新日期：2014-07-01 00:00:00

abstract：OBJECTIVES:To determine the frequency of Th2-mediated allergic diseases (AD) in mainly Th1-driven juvenile idiopathic arthritis (JIA) subtypes. METHODS:Ninety-nine JIA patients and 128 control subjects were enrolled in a prospective case-control study. All subjects were assessed with standard allergy questionnaire, co...

journal_title：Modern rheumatology

authors： Avar-Aydin PO,Nepesov S,Barut K,Sahin S,Adrovic A,Cokugras HC,Kasapcopur O

更新日期：2020-09-07 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a very heterogeneous systemic autoimmune disease, in which autoantibody synthesis against nuclear constituents is the main immunological characteristic. These autoantibodies underwent affinity maturation and isotype switching. Additionally, T-cell tolerance against nuclear autoant...

journal_title：Modern rheumatology

authors： Grossmayer GE,Munoz LE,Gaipl US,Franz S,Sheriff A,Voll RE,Kalden JR,Herrmann M

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVES:To understand the status of mizoribine use in patients with lupus nephritis (LN) and to collect safety- and efficacy-related data on 2-year treatment with mizoribine. METHODS:A continuous survey was conducted between March 2010 and July 2015. RESULTS:The analysis set included 559 patients (mean age 39.5 ye...

journal_title：Modern rheumatology

authors： Takeuchi T,Okada K,Yoshida H,Yagi N

更新日期：2018-01-01 00:00:00

abstract：:To investigate the precise modality of association between SAA1 gene polymorphisms and the development of AA amyloidosis in patients with rheumatoid arthritis (RA), Japanese patients with RA (n=153), among whom 29 were histologically diagnosed as having amyloidosis, were genotyped for three single nucleotide polymorph...

journal_title：Modern rheumatology

authors： Ajiro J,Narita I,Sato F,Saga D,Hasegawa H,Kuroda T,Nakano M,Gejyo F

更新日期：2006-01-01 00:00:00

abstract：OBJECTIVES:The introduction of powerful antirheumatic drugs has dramatically improved the treatment of rheumatoid arthritis (RA), leading clinicians to reconsider the benefits of joint preservation for rheumatoid forefoot deformities. We have employed joint-preserving forefoot surgeries, including rotational closing-we...

journal_title：Modern rheumatology

authors： Yano K,Ikari K,Iwamoto T,Saito A,Naito Y,Kawakami K,Suzuki T,Imamura H,Sakuma Y,Hiroshima R,Momohara S

更新日期：2013-09-01 00:00:00

abstract：:The purpose of this study was to describe the prevalence of total joint arthroplasty (TJA) in Japanese rheumatoid arthritis (RA) patients undergoing conventional drug treatment in a large observational cohort in Japan. A total of 5,177 RA patients were studied for the prevalence of TJA, who were enrolled in the NinJa ...

journal_title：Modern rheumatology

authors： Nishino J,Tanaka S,Matsui T,Mori T,Nishimura K,Eto Y,Kaneko A,Saisho K,Yasuda M,Chiba N,Yoshinaga Y,Saeki Y,Seki A,Tohma S

更新日期：2009-01-01 00:00:00

abstract：OBJECTIVES:We investigated the relationship between morphological features in the lower limbs and the progression of knee osteoarthritis (OA) in 6-years. METHODS:Volunteer subjects from Toei (101 women and 54 men). Knee OA was evaluated on whole-leg radiographs. Subjects were divided into group 1, no knee OA; group 2,...

journal_title：Modern rheumatology

authors： Tran DH,Hoshino H,Matsuyama Y

更新日期：2020-09-03 00:00:00

abstract：:OBJECTIVES: To validate the 2010 histopathological classification system of anti-neutrophil cytoplasmic antibodies (ANCA)-associated glomerulonephritis (GN) in a Japanese single-center cohort. METHODS: We retrospectively studied 54 patients (28 renally limited pauci-immune GN, 25 microscopic polyangiitis, and one Chur...

journal_title：Modern rheumatology

authors： Togashi M,Komatsuda A,Nara M,Omokawa A,Okuyama S,Sawada K,Wakui H

更新日期：2013-04-12 00:00:00

abstract：:Nintedanib (Ofev™), an oral triple kinase inhibitor targeting pro-fibrotic pathways, has been used for treatment of idiopathic pulmonary fibrosis (IPF). Based on positive results from phase III, placebo-controlled, randomized comparative clinical trial conducted in patients with systemic sclerosis-associated interstit...

journal_title：Modern rheumatology

authors： Kuwana M,Azuma A

更新日期：2020-03-01 00:00:00

abstract：:We examined the efficacy and safety of autologous transplantation of bone-marrow-derived cells in patients with intractable ulcers caused by systemic sclerosis. Eight patients with ulcers resistant to treatment were enrolled. Bone marrow cells were gathered from the bilateral iliac crests with multiple repositioning b...

journal_title：Modern rheumatology

authors： Ishigatsubo Y,Ihata A,Kobayashi H,Hama M,Kirino Y,Ueda A,Takeno M,Shirai A,Ohno S

更新日期：2010-06-01 00:00:00

abstract：OBJECTIVES:The aim of our study is to clarify the association of myositis-specific autoantibodies (MSAs) with clinical and laboratory features in Japanese patients with juvenile idiopathic inflammatory myopathies (JIIMs). METHODS:We retrospectively analyzed the frequency of MSAs and their association with clinical or ...

journal_title：Modern rheumatology

authors： Ueki M,Kobayashi I,Takezaki S,Tozawa Y,Okura Y,Yamada M,Kuwana M,Ariga T

更新日期：2019-03-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease. Although hematological anomalies are commonly found in SLE, severe polymorphonuclear leukocyte depletion is rare. Most episodes of severe granulocytopenia in SLE patients tend to occur as part of drug toxicity-induced medullar hypoplasia,...

journal_title：Modern rheumatology

authors： Sakai T,Hatano Y,Abe I,Ishii K,Fujiwara S

更新日期：2013-11-01 00:00:00

abstract：OBJECTIVES:To provide evidence for the revision of clinical practice guideline (CPG) for the management of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) by the Japan Research Committee for Intractable Vasculitis. METHODS:PubMed, CENTRAL, and the Japan Medical Abstracts Society were searched fo...

journal_title：Modern rheumatology

authors： Nagasaka K,Harigai M,Hagino N,Hara A,Horita T,Hayashi T,Itabashi M,Ito S,Katsumata Y,Kawashima S,Naniwa T,Sada KE,Nango E,Nakayama T,Tsutsumino M,Yamagata K,Homma S,Arimura Y

更新日期：2019-01-01 00:00:00

abstract：:Abstract The human major histocompatibility complex (MHC) class I gene HLA-B27 bears a striking association with ankylosing spondylitis and related spondyloarthropathies. This association transcends all ethnic and geographical boundaries. The primary function of HLA-B27 as an MHC class I protein is to form a complex w...

journal_title：Modern rheumatology

authors： Mehra NK,Kanga U

更新日期：2001-12-01 00:00:00

abstract：:Anti-tumor necrosis factor (anti-TNF) biologics are effective in the treatment of rheumatoid arthritis (RA); however, it is still not clear whether this treatment promotes the development of malignancies such as lymphoma. Human T-lymphotropic virus type 1 (HTLV-1), which is a causative agent of adult T-cell lymphoma (...

journal_title：Modern rheumatology

authors： Umekita K,Umeki K,Miyauchi S,Ueno S,Kubo K,Kusumoto N,Takajo I,Nagatomo Y,Okayama A

更新日期：2015-09-01 00:00:00

abstract：:Objective: This study aimed to clarify whether plasma acrolein level actually increases in rheumatoid arthritis (RA) patients, and to elucidate whether any relationship exists between the levels and the RA background variables.Methods: Plasma levels of protein-conjugated acrolein (PC-Acro) in 84 patients (RA group) an...

journal_title：Modern rheumatology

authors： Kawabata C,Nagasawa T,Ono M,Tarumoto N,Katoh N,Hotta Y,Kawano H,Igarashi K,Shiokawa K,Nishimura K

更新日期：2020-06-16 00:00:00

abstract：:Here, we report the case of a 69-year-old man with limited granulomatosis with polyangiitis (GPA; formerly Wegener's granulomatosis) who developed papillary thyroid cancer, adenocarcinoma of the stomach, and myelodysplastic syndrome following glucocorticoid treatment. This is the first report to present multiple malig...

journal_title：Modern rheumatology

authors： Cheon YH,Kim MG,Kim JE,Ha CY,Lee SI,Kim HO

更新日期：2016-01-01 00:00:00

abstract：:Objectives: To evaluate the effectiveness of add-on iguratimod (IGU) in patients with rheumatoid arthritis (RA) who showed an inadequate response to tocilizumab (TCZ), especially patients who were intolerant of an effective dose of methotrexate (MTX). Methods: Thirty-one patients with RA (22 women, age 62.4 years, dis...

journal_title：Modern rheumatology

authors： Ebina K,Miyama A,Tsuboi H,Kaneshiro S,Nishikawa M,Owaki H,Tsuji S,Hirao M,Etani Y,Goshima A,Hashimoto J,Yoshikawa H

更新日期：2019-07-01 00:00:00