Induction of clinical remission with adalimumab-methotrexate combination therapy in a patient with rheumatoid arthritis and concomitant hepatitis C virus infection.

abstract：OBJECTIVES:To determine the availability of bioelectrical impedance analysis (BIA), computed tomography (CT), and magnetic resonance imaging (MRI) for measurement of skeletal muscle mass in patients with rheumatic diseases and quantitatively assess skeletal muscle loss after glucocorticoid (GC) treatment. METHODS:The ...

journal_title：Modern rheumatology

authors： Hosono O,Yoshikawa N,Shimizu N,Kiryu S,Uehara M,Kobayashi H,Matsumiya R,Kuribara A,Maruyama T,Tanaka H

更新日期：2015-03-01 00:00:00

abstract：OBJECTIVE:Upper limit of methotrexate (MTX) for patients with rheumatoid arthritis (RA) was recently increased from 8 to 16 mg/week in Japan. We therefore examined the effect of concomitant MTX dose on the efficacy of adalimumab (ADA) in clinical practice. METHOD:Sixty-one consecutive RA patients treated with ADA were...

journal_title：Modern rheumatology

authors： Nakashima Y,Miyahara H,Kondo M,Fukuda T,Harada H,Haraguchi A,Inoue Y,Ishinishi T,Maekawa M,Maeyama A,Nakashima M,Shono E,Suematsu E,Shimauchi T,Tsuru T,Tsukamoto H,Yoshizawa S,Yoshizawa S,Iwamoto Y

更新日期：2017-01-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to investigate the effect and potential mechanism of Cysteine-rich 61 (Cyr61) on stimulating MMP-3 expression by fibroblast-like synoviocytes (FLS) from rheumatoid arthritis (RA) patients. METHODS:Primarily cultured RA FLS were treated with exogenous Cyr61 protein or Cyr61-siRNA, t...

journal_title：Modern rheumatology

authors： Zhai T,Gao C,Huo R,Sheng H,Sun S,Xie J,He Y,Gao H,Li H,Zhang J,Li H,Sun Y,Lin J,Shen B,Xiao L,Li N

更新日期：2017-05-01 00:00:00

abstract：:A 49-year-old Japanese woman treated with oral corticosteroids, methotrexate, and infliximab for malignant rheumatoid arthritis was admitted because of fever and low back pain. The white blood cell count and C-reactive protein concentration were elevated. Lumbar and pelvic computed tomography showed enlargement of the...

journal_title：Modern rheumatology

authors： Oda S,Fujinaga H,Takahashi K

更新日期：2006-01-01 00:00:00

abstract：AIM:The purpose of this study was to assess morphological changes in the paravertebral muscles in patients with ankylosing spondylitis. MATERIALS AND METHODS:Fifty-one patients diagnosed with ankylosing spondylitis and a 50 member control group were included in the study. The surface area of the multifidus and erector...

journal_title：Modern rheumatology

authors： Resorlu H,Savas Y,Aylanc N,Gokmen F

更新日期：2017-07-01 00:00:00

abstract：OBJECTIVES:Locomotive syndrome (LS) encompasses conditions that may lead to the need for nursing services. We aimed to quantify the association between exercise habits during youth or the middle-age years and both physical function and the presence of LS in Japanese elderly people. METHODS:We examined 460 participants...

journal_title：Modern rheumatology

authors： Nishimura A,Ito N,Asanuma K,Akeda K,Ogura T,Sudo A

更新日期：2018-03-01 00:00:00

abstract：OBJECTIVES:This study aimed to identify the prevalence of scoliosis and scoliosis-related factors of rheumatoid arthritis (RA). METHODS:In this study, 411 patients who underwent coronal total spine and lower limb radiography were enrolled. Patients with a Cobb angle ≥10° were diagnosed with scoliosis. Statistical anal...

journal_title：Modern rheumatology

authors： Mochizuki T,Yano K,Ikari K,Hiroshima R,Takaoka H,Kawakami K,Koenuma N,Ishibashi M,Shirahata T,Momohara S

更新日期：2016-01-01 00:00:00

abstract：:Abstract We report a case of hypocalcemic myopathy confounded by polymyositis due to an elevated level of serum creatine kinase (CK). A 30-year-old man was referred to our hospital for the treatment of provisionally diagnosed polymyositis. His presentation with tetany, hyporeflexia, and general fatigue, in addition to...

journal_title：Modern rheumatology

authors： Hirata D,Nagashima T,Saito S,Okazaki H,Kano S,Minota S

更新日期：2002-06-01 00:00:00

abstract：:IgG4-related disease (IgG4-RD) is a fascinating clinical entity first reported in this century in Japan, and includes a wide variety of diseases, such as formerly named Mikulicz's disease (MD), autoimmune pancreatitis (AIP), interstitial nephritis, prostatitis and retroperitoneal fibrosis. The Japanese IgG4 team organ...

journal_title：Modern rheumatology

authors： Umehara H,Okazaki K,Kawa S,Takahashi H,Goto H,Matsui S,Ishizaka N,Akamizu T,Sato Y,Kawano M,Research Program for Intractable Disease by the Ministry of Health, Labor and Welfare (MHLW) Japan.

更新日期：2021-01-28 00:00:00

abstract：:Abstract  Osteoarthritis (OA) is considered to be a complex illness in which the tissues of the joint play a significant role in the initiation and/or progression of the pathophysiology. We still do not completely understand what initiates the degradation and loss of cartilage. However, it has been suggested that incr...

journal_title：Modern rheumatology

authors： Lajeunesse D,Massicotte F,Pelletier JP,Martel-Pelletier J

更新日期：2003-03-01 00:00:00

abstract：OBJECTIVES:To evaluate the long-term efficacy and safety of certolizumab pegol (CZP) plus methotrexate treatment and to assess the efficacy of two CZP maintenance dosing schedules in Japanese rheumatoid arthritis (RA) patients with an inadequate response to methotrexate. METHODS:J-RAPID double-blind patients were ente...

journal_title：Modern rheumatology

authors： Tanaka Y,Yamamoto K,Takeuchi T,Yamanaka H,Ishiguro N,Eguchi K,Watanabe A,Origasa H,Shoji T,Miyasaka N,Koike T

更新日期：2014-09-01 00:00:00

abstract：:The involvement of valgus hindfoot deformity in hallux valgus deformity was confirmed in a rheumatoid arthritis case with a destructive valgus hindfoot deformity. Correction of severe valgus, calcaneal lateral offset, and pronated foot deformity instantly normalized hallux valgus deformities postoperatively. Thus, car...

journal_title：Modern rheumatology

authors： Yamada S,Hirao M,Tsuboi H,Akita S,Matsushita M,Ohshima S,Saeki Y,Hashimoto J

更新日期：2014-09-01 00:00:00

abstract：:Abstract A 56-year-old man presented with hyperproteinemia and renal dysfunction associated with antineutrophil cytoplasmic antibodies (ANCA). He had had a ventriculoperitoneal shunt tube made of silicone implanted 4 years earlier. In his renal biopsy, necrotizing crescentic glomerulonephritis was identified: tests fo...

journal_title：Modern rheumatology

authors： Bohgaki M,Mukai M,Notoya A,Kohno M,Takada A

更新日期：2003-03-01 00:00:00

abstract：:Clinical squeal of the treatment of rheumatoid arthritis patients with methotrexate (MTX) according to the Japanese government recommended dose of 8 mg/week was evaluated prospectively. A total of 176 patients with active RA attending Konan Kakogawa Hospital and Kobe University Hospital were enrolled. Patients' profil...

journal_title：Modern rheumatology

authors： Hashiramoto A,Shiozawa K,Tanaka Y,Yamane T,Murata M,Tanaka C,Terashima Y,Koyama K,Nakagawa N,Abe S,Yoshihara R,Saegusa Y,Tsumiyama K,Komai K,Sakai Y,Shiozawa S

更新日期：2009-01-01 00:00:00

abstract：:We examined the therapeutic effect of high molecular weight hyaluronic acid (HA) on the progression of joint pain and cartilage degeneration in a rabbit osteoarthritis (OA) model. The OA model was induced by partial meniscectomy. In the time course study, cartilage degeneration was assessed at 3, 7 and 14 days after o...

journal_title：Modern rheumatology

authors： Hashizume M,Koike N,Yoshida H,Suzuki M,Mihara M

更新日期：2010-10-01 00:00:00

abstract：:Tumor necrosis factor alpha (TNFalpha)-blocking agents have been used increasingly in the treatment of severe refractory juvenile idiopathic arthritis (JIA). However, some patients have been forced to discontinue these agents because of the lack of efficacy or adverse events. In these situations, cases of switching fr...

journal_title：Modern rheumatology

authors： Nerome Y,Imanaka H,Nonaka Y,Takei S

更新日期：2007-01-01 00:00:00

abstract：:Hyperimmunoglobulin E syndrome (HIES) is a primary immunodeficiency disorder with multisystem abnormalities including the vascular system. We report a child with autosomal recessive (AR)-HIES secondary to dedicator of cytokinesis 8 (DOCK8) deficiency who developed critical aortic aneurysm involving the ascending aorta...

journal_title：Modern rheumatology

authors： Al Mutairi M,Al-Mousa H,AlSaud B,Hawwari A,AlJoufan M,AlWesaibi A,AlHalees Z,Al-Mayouf SM

更新日期：2014-07-01 00:00:00

abstract：:We report a novel case of eosinophilic orbital myositis associated with Churg-Strauss syndrome. A 56-year-old man with a 20-year history of chronic sinusitis and seasonal allergic rhinitis was admitted because of fever, swelling of cheeks and extremities, diplopia, and eosinophilia. With findings from gadolinium-enhan...

journal_title：Modern rheumatology

authors： Fujii T,Norizuki M,Kobayashi T,Yamamoto M,Kishimoto M

更新日期：2010-04-01 00:00:00

abstract：:Cutaneous polyarteritis nodosa (CPAN) is a form of necrotizing vasculitis of small and medium-sized arteries. It is limited to the skin and has a recurrent and chronic course, possibly associated with fever, arthralgia, myalgia and neuropathy, but without visceral involvement. We report the clinical case of a 7-year-o...

journal_title：Modern rheumatology

authors： Valor L,Monteagudo I,de la Torre I,Fernández CG,Montoro M,Longo JL,Carreño L

更新日期：2014-07-01 00:00:00

abstract：:We report two cases of clinically amyopathic dermatomyositis (CADM) complicated by rapid progress interstitial lung disease (RPILD). The diagnosis of CADM was based on Gottron's papule and RPILD, and the absence of muscle weakness. The female patients were treated with early immunosuppressive therapies including stero...

journal_title：Modern rheumatology

authors： Horai Y,Isomoto E,Koga T,Okada A,Kawashiri SY,Tamai M,Yamasaki S,Nakamura H,Origuchi T,Hamaguchi Y,Fujimoto M,Kuwana M,Kawakami A

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVES:The objective of this study is to evaluate the efficacy and safety of long-term (64 weeks; 52-week extension of a 12-week study) baricitinib treatment in Japanese patients with active rheumatoid arthritis (RA) despite methotrexate therapy. METHODS:Patients (N = 145) with active RA were randomized to placebo...

journal_title：Modern rheumatology

authors： Tanaka Y,Ishii T,Cai Z,Schlichting D,Rooney T,Macias W

更新日期：2018-01-01 00:00:00

abstract：:Abstract We report a rare case of a 17-year-old female with overlap syndrome (systemic lupus erythematosus and systemic sclerosis) who developed severe abdominal pain and bloody diarrhea accompanied by central nervous system lupus. Colonoscopy revealed multiple irregular and linear ulcers throughout the colon, which w...

journal_title：Modern rheumatology

authors： Ota Y,Nozue N,Dei Y,Kondo S,Ohashi H

更新日期：2003-12-01 00:00:00

abstract：OBJECTIVE:To obtain safety and efficacy data on combination treatment with iguratimod and methotrexate (MTX) in an open-label extension study in patients with active rheumatoid arthritis (RA). METHODS:Following a 28-week, randomized, double-blind trial of adding iguratimod or placebo to stable MTX therapy, patients en...

journal_title：Modern rheumatology

authors： Hara M,Ishiguro N,Katayama K,Kondo M,Sumida T,Mimori T,Soen S,Nagai K,Yamaguchi T,Yamamoto K,Iguratimod-Clinical Study Group.

更新日期：2014-05-01 00:00:00

abstract：OBJECTIVE:Evaluate the association between the multi-biomarker disease activity (MBDA) score and radiographic progression in patients with rheumatoid arthritis (RA) treated with tumor necrosis factor (TNF)-α inhibitors. METHODS:Change (Δ) in modified total Sharp score (mTSS) over 52 weeks and disease activity scores w...

journal_title：Modern rheumatology

authors： Hirata S,Li W,Kubo S,Fukuyo S,Mizuno Y,Hanami K,Sawamukai N,Yamaoka K,Saito K,Defranoux NA,Tanaka Y

更新日期：2016-11-01 00:00:00

abstract：OBJECTIVES:To assess changes in salivary epidermal growth factor (EGF) levels within three years and investigate the correlation between these changes and the severity of intraoral manifestations in patients with Sjögren's syndrome (SS). METHODS:Twenty-three SS patients (14 primary SS and 9 secondary SS) and 14 contro...

journal_title：Modern rheumatology

authors： Azuma N,Katada Y,Kitano S,Sekiguchi M,Kitano M,Nishioka A,Hashimoto N,Matsui K,Iwasaki T,Sano H

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVE:Intra-articular (IA) injection of hyaluronic acid (HA) has been shown to relieve osteoarthritis (OA)-related pain and improve joint structure within a 1-year period. We examined the mid-term (2-year) efficacy of IA-HA in Japanese subjects by using a large-scale population-based cohort of the Research on Osteo...

journal_title：Modern rheumatology

authors： Oka H,Akune T,Muraki S,Tanaka S,Kawaguchi H,Nakamura K,Yoshimura N

更新日期：2013-07-01 00:00:00

abstract：:Inflammation has often been considered to be a nonspecific response and to play a bridging role in the activation of adaptive immunity. However, it is now accepted that inflammation is the product of an independent innate immune system closely linked to the adaptive immune system. The key mediators of inflammation are...

journal_title：Modern rheumatology

authors： Yokota S,Kikuchi M,Nozawa T,Kanetaka T,Sato T,Yamazaki K,Sakurai N,Hara R,Mori M

更新日期：2015-01-01 00:00:00

abstract：:Blau syndrome/early-onset sarcoidosis (Blau/EOS) is an autoinflammatory disease characterized by granulomatous arthritis, uveitis, and skin rash. It has been shown that gain-of-function NOD2 mutations cause Blau/EOS. In this paper, we describe a patient with a gain-of-function NOD2 mutation who developed infantile Tak...

journal_title：Modern rheumatology

authors： Inoue Y,Kawaguchi Y,Shimojo N,Yamaguchi K,Morita Y,Nakano T,Arima T,Tomiita M,Kohno Y

更新日期：2013-07-01 00:00:00

abstract：OBJECTIVES:To determine the frequency of Th2-mediated allergic diseases (AD) in mainly Th1-driven juvenile idiopathic arthritis (JIA) subtypes. METHODS:Ninety-nine JIA patients and 128 control subjects were enrolled in a prospective case-control study. All subjects were assessed with standard allergy questionnaire, co...

journal_title：Modern rheumatology

authors： Avar-Aydin PO,Nepesov S,Barut K,Sahin S,Adrovic A,Cokugras HC,Kasapcopur O

更新日期：2020-09-07 00:00:00

abstract：OBJECTIVES:To evaluate the therapeutic efficacy of a novel inhibitor for IκB kinase alpha (IKKα), noraristeromycin (NAM), for murine experimental model of rheumatoid arthritis, collagen- induced arthritis (CIA). METHODS:NAM has been chemically synthesized as reported earlier. CIA was induced in DBA/1JNCrlj mice by int...

journal_title：Modern rheumatology

authors： Ito M,Hamano T,Komatsu T,Asamitsu K,Yamakawa T,Okamoto T

更新日期：2014-09-01 00:00:00