Association between adiponectin receptor 1 gene polymorphism and insulin resistance in Chinese patients with polycystic ovary syndrome.

Abstract:

BACKGROUND/AIMS:Adiponectin receptor 1 (ADIPOR1) is an identified receptor for adiponectin, an adipocytokine with anti-inflammatory and insulin-sensitizing properties. The ADIPOR1 gene is a potential candidate gene in polycystic ovary syndrome (PCOS). The aim of this study is to assess the association between single-nucleotide polymorphism (SNP) rs1539355 in the ADIPOR1 gene and PCOS in Chinese women. METHODS:302 patients with PCOS and 312 healthy controls were included in this study. The ADIPOR1 genotype distribution was detected using the polymerase chain reaction melting temperature shift method. RESULTS:The genotypic distributions of SNP rs1539355 did not differ in patients with PCOS compared to controls. However, the frequency of the G allele in the PCOS group was significantly higher than that in the control group (p = 0.037). Patients with the AG or GG genotype had a higher homeostasis model assessment for insulin resistance (HOMA-IR) (p < 0.05) compared to patients with the AA genotype. The fasting insulin levels in subjects with the GG genotype were significantly higher than those in patients with the AA genotype (p < 0.05). CONCLUSION:SNP rs1539355 in the ADIPOR1 gene is associated with insulin resistance in Chinese PCOS patients.

journal_name

Gynecol Obstet Invest

authors

Yang Z,Yang X,Xu J,Sun Y,Shi Y,Fang S

doi

10.1159/000356960

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

45-9

issue

1

eissn

0378-7346

issn

1423-002X

pii

000356960

journal_volume

77

pub_type

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