Plasma 5'-nucleotidase activities and uric acid levels in women with pre-eclampsia.

Abstract:

:The present study investigated plasma activity of 5'-nucleotidase, a key enzyme in the production of adenosine, in pre-eclampsia, and evaluated the relationship between changes in 5'-nucleotidase activity, and levels of uric acid, endproduct of the purine metabolism, and the severity of pre-eclampsia. We measured plasma 5'-nucleotidase activities and uric acid levels in women with 18 normal pregnancies, mild and severe pre-eclampsia. In mild and severe pre-eclampsia, plasma 5'-nucleotidase activities and uric acid levels were significantly increased compared with those in normal pregnancy (p < 0.05). Plasma 5'-nucleotidase activity increased according to increases in uric acid levels and the severity of pre-eclampsia. These results suggest that increased plasma 5'-nucleotidase activity may, at least in part, be related to changes in purine metabolism in pre-eclampsia.

journal_name

Gynecol Obstet Invest

authors

Yoneyama Y,Suzuki S,Sawa R,Otsubo Y,Miura A,Kuwabara Y,Ishino H,Kiyokawa Y,Doi D,Yoneyama K,Kobayashi H,Araki T

doi

10.1159/000067886

keywords:

subject

Has Abstract

pub_date

2002-01-01 00:00:00

pages

168-71

issue

3

eissn

0378-7346

issn

1423-002X

pii

67886

journal_volume

54

pub_type

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