Human Chorionic Gonadotropin Regression Curves after Partial or Complete Molar Pregnancy in Flanders: Are They Different from Regression Curves from the Eighties?

Abstract:

BACKGROUND/AIMS:We updated human chorionic gonadotropin (hCG) regression curves created in the eighties after evacuation of complete and partial molar (CM and PM, respectively) pregnancies using modern hCG assays. We created similar curves for patients in need of chemotherapy (gestational trophoblastic neoplasia [GTN]). METHODS:A total of 126 patients who were diagnosed with gestational trophoblastic disease from 1990 to 2014 were included. We compared curves from 2 groups, CM and PM, with historical ones. The third group was a comparison of GTN patients receiving first-line chemotherapy and patients in need of a switch of chemotherapy. RESULTS:The regression curves were comparable to historical ones. According to the latter, mean time to normalization was 14-15 weeks after evacuation. We observed a normalization within 12 (CM) and 12.7 (PM) weeks. In addition, a remarkable but not statistically significant vertical shift (20 IU/L higher) was observed prior to day 60 compared with historical curves. The comparison in GTN patients showed a statistical significant difference, even at day 7. CONCLUSION:The presented hCG regression curves in the Flemish region were comparable with the ones of the eighties but with a vertical shift, hypothetically due to more sensitive assays. In addition, regression curves in GTN patients receiving chemotherapy can be used to evaluate response.

journal_name

Gynecol Obstet Invest

authors

Delattre S,Han S,Moerman P,Billen J,Goffin F,Scharpé K,Vergote I

doi

10.1159/000458523

subject

Has Abstract

pub_date

2018-01-01 00:00:00

pages

76-82

issue

1

eissn

0378-7346

issn

1423-002X

pii

000458523

journal_volume

83

pub_type

杂志文章
  • Metastatic choriocarcinoma presenting in a gravid woman.

    abstract::Choriocarcinoma coexistent with an intrauterine pregnancy is rare and requires decisions affecting mother and child to treat this aggressive tumor. An instance of this situation is presented to highlight clinical circumstances that warrant departure from accepted dogma. Pathologic aspects of choriocarcinoma are also d...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000363234

    authors: Byrd K,Seay R,Bechert CJ,Maxwell GL,Bicher A

    更新日期:2015-01-01 00:00:00

  • Hysterectomy and lower urinary tract symptoms: a nonrandomized comparison of vaginal and abdominal hysterectomy.

    abstract:BACKGROUND/AIMS:It has been reported that lower urinary tract symptoms (LUTS) are more prevalent in patients who have undergone hysterectomy. However, the effects of surgical approach of hysterectomy on micturition have not been well documented. The aim of this study is to compare LUTS between patients who underwent va...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章,多中心研究

    doi:10.1159/000297507

    authors: Lakeman MM,van der Vaart CH,Roovers JP,HysVA study group.

    更新日期:2010-01-01 00:00:00

  • Modified hysteroscopic myomectomy of large submucous fibroids.

    abstract:OBJECTIVE:To compare the efficacy, feasibility, operative time and possible complications of a modified technique of hysteroscopic removal of large submucus myomata versus traditional morcellation technique, and to assess the efficacy of preoperative sonohysterography (SHG). DESIGN:A prospective comparative study. SE...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000074451

    authors: Darwish A

    更新日期:2003-01-01 00:00:00

  • Prospective Randomized Trial Comparing Embryo Transfers of Cases with and without Catheter Rotation during Its Withdrawal.

    abstract:OBJECTIVE:To compare embryo transfer (ET) technique based on catheter rotation during its withdrawal in cases with unexplained infertility in a prospective, randomized trial (NCT03097042). METHODS:Two hundred intracytoplasmic sperm injection (ICSI) patients undergoing ET with cleaving or blastocyst-stage fresh embryos...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章,随机对照试验

    doi:10.1159/000489493

    authors: Yayla Abide C,Ozkaya E,Sanverdi I,Bostancı Ergen E,Kurek Eken M,Devranoglu B,Bilgiç BE,Kilicci C,Kayatas Eser S

    更新日期:2018-01-01 00:00:00

  • Cervical partial hydatidiform molar pregnancy.

    abstract:BACKGROUND:Cervical hydatidiform molar pregnancy is an exceedingly rare occurrence that has been reported only twice before. CASE:We report a 25-year-old, G4P1D&C2 woman with a positive pregnancy test and vaginal bleeding. A cervical pregnancy with hydatidiform mole was detected on transvaginal ultrasound and color Do...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000141647

    authors: Aytan H,Caliskan AC,Demirturk F,Koseoglu RD,Acu B

    更新日期:2008-01-01 00:00:00

  • Consecutive pregnancies in a menopausal woman following oocyte donation.

    abstract::A second pregnancy was successfully achieved by a menopausal women who had previously conceived and delivered an infant using donated oocytes. The same nonanonymous oocyte donor provided the gametes for both procedures. Prior to embryo transfer, the functionally agonadal recipient received exogenous steroid hormone re...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000293009

    authors: Sauer MV,Paulson RJ

    更新日期:1991-01-01 00:00:00

  • Evaluation of fetal sonographic measurements in the first trimester by transvaginal sonography.

    abstract::To assess the reliability of early biometric measurements in pregnancy, transvaginal sonography was performed in 92 pregnancies in the first trimester in a cross-sectional fashion. Measurements included crown-to-rump length (CRL), biparietal diameter (BPD), head and abdominal circumference (HC and AC), and femur lengt...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000293032

    authors: Izquierdo LA,Kushnir O,Smith JF,Gilson GJ,Chatterjee MS,Qualls C,Curet LB

    更新日期:1991-01-01 00:00:00

  • Low myometrial glycogen content compared with rectus muscle in term pregnant women before labor.

    abstract::Glycogen, glucose, some nucleosides and purine base derivatives were determined in biopsies from 10 term pregnant women undergoing elective cesarean sections before labor. The concentrations were compared in the biopsies which were cut from isthmus and fundus of the uterus and m. rectus abdominis. M. rectus biopsies h...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000010086

    authors: Steingrímsdóttir T,Ronquist G,Ulmsten U,Waldenström A

    更新日期:1999-01-01 00:00:00

  • Intraoperative Ultrasound during Fertility-Sparing Surgery: A Systematic Review and Practical Applications.

    abstract::Fertility-sparing surgery (FSS) is an established concept within operative gynaecology. Intraoperative ultrasound (IOUS) has the potential of assessing lesion margins, allowing complete resection with minimal damage to the surrounding healthy tissue and could potentially play a major role in FSS for benign or malignan...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000505689

    authors: Galazis N,Saso S,Sorbi F,Jones B,Landolfo C,Al-Memar M,Ben-Nagi J,Smith JR,Yazbek J

    更新日期:2020-01-01 00:00:00

  • Sacral mesh pullout strength based on suture location for sacrocolpopexy.

    abstract:BACKGROUND:We sought to compare the pullout strengths of the sacral end of the sacrocolpopexy mesh when attached using one suture at the first versus second sacral vertebral level (S1 vs. S2) in female cadaveric pelvises. METHODS:The sacral vertebrae were isolated in 9 unembalmed female cadavers, and segments of polyp...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000338892

    authors: Shippey S,Sutter E,Belkoff SM,Gutman R,Chen CC

    更新日期:2012-01-01 00:00:00

  • Effect of the carbon dioxide laser on the oviducts of rabbits.

    abstract::Oviducts of 35 mature, white New Zealand rabbits were injured by a laser beam, using various powers from 25 to 40 W, and by a series of pulses of 1/10, 1/20 or 1/100 s duration. The contralateral oviducts served as controls and were injured at similar areas by a scalpel. The injured areas of both tubes were histologic...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000299610

    authors: David A,Nebel L,Serr DM,Czernobilsky B,Gaton E

    更新日期:1981-01-01 00:00:00

  • Longitudinal measurement of amniotic fluid index in term pregnancies and its association with intrapartum fetal distress.

    abstract:OBJECTIVE:The aim of the present study was to evaluate the dynamic changes in serially obtained amniotic fluid index values and to determine any association with intrapartum fetal distress in a term population. MATERIALS AND METHODS:All patients, > or = 40 weeks of gestational age, evaluated at the Institute of Obstet...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000291535

    authors: Garzetti GG,Ciavattini A,La Marca N,De Cristofaro F

    更新日期:1997-01-01 00:00:00

  • Perinatal environment and endometriosis.

    abstract:BACKGROUND/AIMS:Perinatal environmental exposure may affect fetal development and reprogram the developing organism for adult-onset disease. In this case-control study, we aimed at assessing this pathogenetic model in endometriosis. METHODS:Consecutive patients with a first laparoscopic diagnosis of endometriosis were...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000323531

    authors: Somigliana E,Vigano P,Abbiati A,Paffoni A,Benaglia L,Vercellini P,Fedele L

    更新日期:2011-01-01 00:00:00

  • RCAS1 decidual immunoreactivity during cesarean section in scar deciduosis: immune cell presence and activity.

    abstract:INTRODUCTION:Scar deciduosis provides a research model that enables us to assess the impact of decidua on the activity and quality of the immune cells infiltrating this scar tissue. This unique model allows us to examine these processes under conditions excluding the impact of placental cells which, along with decidual...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000111533

    authors: Skret-Magierlo J,Wicherek L,Basta P,Galazka K,Sikora J,Wilk M,Fudali L,Skret A

    更新日期:2008-01-01 00:00:00

  • Human papillomavirus DNA in triple neoplasms of the cervix, perianus and ureter in one woman.

    abstract:BACKGROUND:Multiple malignancies of the urogenital tract have been reported. We investigated the etiological role of human papillomavirus (HPV) in the pathogenesis of urogenital cancers. CASE:We present a case of cervical squamous carcinoma in a 64-year-old woman who subsequently developed Bowen's disease in the peria...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000097139

    authors: Huang LW,Pan HS,Lin YH,Chou KY

    更新日期:2007-01-01 00:00:00

  • Ectopic pregnancy rates after frozen versus fresh embryo transfer: a meta-analysis.

    abstract:BACKGROUND/AIMS:The aim of this meta-analysis was to determine whether frozen embryo transfer (ET) increases ectopic pregnancy (EP) rate compared with fresh ET. METHODS:A meta-analysis was performed of data from seven comparative studies including 13,059 pregnancies that resulted from nondonor in vitro fertilization c...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章,meta分析

    doi:10.1159/000213048

    authors: Jee BC,Suh CS,Kim SH

    更新日期:2009-01-01 00:00:00

  • Expression of the Peptidase "Fibroblast Activation Protein" on Decidual Stromal Cells Facilitating Tissue Remodeling.

    abstract:INTRODUCTION:Expression of fibroblast activation protein (FAP) has been detected in activated fibroblasts participating in injury response, fibrotic and inflammatory conditions, and tumorigenesis. Human endometrium is equally characterized by rapid tissue remodeling events due to the reproductive tasks comprising the a...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000511439

    authors: Segerer SE,Bartmann C,Schwab M,Kämmerer U

    更新日期:2020-01-01 00:00:00

  • Evaluation of the total lung profile, including the two-dimensional L/S ratio for the establishment of fetal lung maturation.

    abstract::Recently some articles have been published in which the total lung profile has been introduced to determine the fetal lung maturation. In the present study the two-dimensional L/S ratio and the total lung profile, especially the phosphatidyl-glycerol content, are compared with the conventional one-dimensional L/S rati...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000299461

    authors: Feijen HW,Di Renzo GC,Nederstigt J,Houx PC,Eskes TK

    更新日期:1982-01-01 00:00:00

  • Spontaneous expulsion of a Filshie clip through the anterior abdominal wall.

    abstract::Tubal occlusion using Filshie clip is one of the most commonly performed operations for female sterilization. It is usually a simple and safe procedure, and operative complications are uncommon. We report a rare case of spontaneous expulsion of a Filshie clip through the anterior abdominal wall 5 years after steriliza...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章,评审

    doi:10.1159/000070615

    authors: Lok IH,Lo KW,Ng JS,Tsui MH,Yip SK

    更新日期:2003-01-01 00:00:00

  • Proteoglycans from cultures of fibroblast from the human uterine cervix.

    abstract::A small dermatan sulphate proteoglycan has been isolated from the human uterine cervix. The concentration of this proteoglycan has been shown to decrease during pregnancy. To study the mechanism behind this change fibroblasts from the human uterine cervix were established in culture. Their synthesis and secretion of p...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000299026

    authors: Uldbjerg N,Malmström A,Ekman G,Ulmsten U

    更新日期:1985-01-01 00:00:00

  • When is the optimal time for delivery?--Purely from the fetuses' perspective.

    abstract::To determine when the extrauterine environment becomes safer than the intrauterine environment with respect to fetal (neonatal) life, we analyzed all 4,896,505 livebirths, all 21,222 stillbirths, and all 7,513 early neonatal deaths after 26 weeks gestation that were recorded between 1989 and 1992 in Japan. Although th...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000292330

    authors: Minakami H,Kimura H,Honma Y,Tamada T,Sato I

    更新日期:1995-01-01 00:00:00

  • Endometrial cyst, dermoid cyst and mucinous cystadenoma sonographically evidenced in the same ovary.

    abstract::We treated a patient with an ovarian tumor histologically consisting of an endometrial cyst, dermoid cyst and mucinous cystadenoma, in the same ovary. A comparative study between ultrasonic and histological findings was done. The usefulness, drawbacks and limitations in the ultrasonic evaluation of ovarian tumors are ...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000293646

    authors: Hata K,Hata T,Kitao M,Aoki S,Matsunaga I

    更新日期:1989-01-01 00:00:00

  • Compensatory mechanisms which prevent urinary incontinence in aging women.

    abstract::The relationship between age and urodynamic parameters was studied cross-sectionally in a group of 28 women in whom clinically and urodynamically both stress incontinence and detrusor instability were excluded (no proven incontinence, NPI) and in a group, matched for age, with genuine stress incontinence (GSI). At all...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000294858

    authors: Wijma J,Tinga DJ,Visser GH

    更新日期:1992-01-01 00:00:00

  • Is Maternal Blood Procalcitonin Level a Reliable Predictor for Early Onset Neonatal Sepsis in Preterm Premature Rupture of Membranes?

    abstract:BACKGROUND:This study is aimed at comparing the early diagnostic accuracy of maternal blood white blood cell (WBC) count, C-reactive protein (CRP) and procalcitonin in predicting early onset neonatal sepsis (EONS) among early preterm premature rupture of membrane (PPROM) pregnancies. METHODS:A total of 57 consecutive ...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000446949

    authors: Cetin O,Aydın ZD,Verit FF,Zebitay AG,Karaman E,Elasan S,Turfan M,Yucel O

    更新日期:2017-01-01 00:00:00

  • A simple scoring system for the treatment of cervical incompetence diagnosed during the second trimester.

    abstract::Twenty-four women with second-trimester cervical incompetence underwent emergency cerclage. The appropriateness of cervical cerclage was analyzed according to a scoring system (Cervical Incompetence Scale; CIS) which measures the degree of cervical effacement, cervical dilatation and protrusion of fetal membranes into...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000293093

    authors: Kokia E,Dor J,Blankenstein J,Seidman DS,Lipitz S,Serr DM,Mashiach S

    更新日期:1991-01-01 00:00:00

  • Changes in plasma norepinephrine in normal labor following isometric contraction.

    abstract::Changes in norepinephrine following a bimanual handgrip contraction test were used to evaluate the contribution of static physical effort exerted by the parturient on the rise in adrenergic stimulation observed during ongoing labor. Noradrenaline baseline values were 306.71 +/- (SE) 21.5 pg/ml); and after a maximal ef...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000298871

    authors: Rabinovici J,Rosenthal T,Peleg E,Mashiach S

    更新日期:1987-01-01 00:00:00

  • Pregnancy rate after homologous insemination of pathological ejaculate both with and without the addition of kallikrein.

    abstract::As part of a gynecological-andrological cooperation programme for the treatment of infertile marriages made by the 1st Department of Obstetrics and Gynecology and the Department of Urology, University of Vienna Medical School, the pregnancy rates achieved through 1,269 homologous inseminations of pathological ejaculat...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000299429

    authors: Maier U,Grünberger W,Binstorfer E,Lunglmayr G

    更新日期:1983-01-01 00:00:00

  • Estrogen-producing ovarian adenocarcinoma with large abscess formation.

    abstract::We report a postmenopausal patient with serous papillary cystadenocarcinoma of the ovary associated with large abscess formation and estrogen production. Ovarian cancer accompanied by stromal function is an occasional event, but large abscess association is a rarity. The present case is thus even rarer. Her clinical c...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000292710

    authors: Yoshida M,Katsuragawa H,Miyamoto U,Ohnishi S,Katsura Y

    更新日期:1993-01-01 00:00:00

  • Pathophysiology and possible iatrogenic cause of leiomyomatosis peritonealis disseminata.

    abstract::We present a case of leiomyomatosis peritonealis disseminata (LPD) after myoma morcellation and review the literature using the keywords leiomyomatosis peritonealis disseminata and disseminated peritoneal leiomyomatosis. The search was conducted in Medline, EMBASE, and Cochrane Database of systematic reviews. We encou...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章,评审

    doi:10.1159/000274487

    authors: Al-Talib A,Tulandi T

    更新日期:2010-01-01 00:00:00

  • Anaerobic vaginosis: treatment with tinidazole vaginal tablets.

    abstract::A prospective randomized trial comprising 90 patients was undertaken to evaluate three different regimens of tinidazole in the treatment of anaerobic vaginosis. Each group consisted of 30 women. The three regimens were: (A) oral tinidazole (150 mg X 2) for 7 days, (B) same oral treatment as above but also the partner ...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000293524

    authors: Heikkinen J,Vuopala S

    更新日期:1989-01-01 00:00:00