Abstract:
INTRODUCTION:Expression of fibroblast activation protein (FAP) has been detected in activated fibroblasts participating in injury response, fibrotic and inflammatory conditions, and tumorigenesis. Human endometrium is equally characterized by rapid tissue remodeling events due to the reproductive tasks comprising the activity of proteolytic enzymes. OBJECTIVE:We therefore hypothesized that FAP-positive fibroblasts could also be involved in physiological processes requiring tissue remodeling, such as decidualization during early pregnancy. METHODS/RESULTS:The expression of FAP was analyzed by immunohistochemistry in frozen sections of decidual tissue from early pregnancy (gestational weeks: 6-12). All tissue samples clearly displayed a strong expression of FAP on the surface of stromal fibroblasts. Additionally, the percentage of FAP-positive fibroblasts freshly isolated from the decidua of the corresponding gestational weeks was calculated by applying FACS analysis. Decidual fibroblasts of different gestational weeks showed a significant decrease in FAP expression between the 6th and 7th weeks of gestation, which was followed by a steady slow reconstitution. By analyzing the expression of cytokines, chemokines, and growth factors of isolated FAP-positive decidual fibroblasts, we detected high levels of monocyte-attracting chemokines (growth-related oncogene alpha and monocyte chemoattractant protein-1 and -2), granulocyte-attracting chemokines (e.g., IL-8), proinflammatory factors (IL-1α and tumor necrosis factor alpha), and angiogenic substances (e.g., vascular endothelial growth factor and IL-8), which all promote an optimal microenvironment for implantation and growth of the conceptus. CONCLUSIONS:Our data demonstrate that the healthy early pregnancy decidua is characterized by a general occurrence of FAP-positive fibroblasts possibly participating in active tissue remodeling during implantation.
journal_name
Gynecol Obstet Investjournal_title
Gynecologic and obstetric investigationauthors
Segerer SE,Bartmann C,Schwab M,Kämmerer Udoi
10.1159/000511439subject
Has Abstractpub_date
2020-01-01 00:00:00pages
428-436issue
5eissn
0378-7346issn
1423-002Xpii
000511439journal_volume
85pub_type
杂志文章abstract::Hysteroscopic surgery is widely used for the treatment of patients suffering from menorrhagia. In different studies, pretreatment of the endometrium with GnRH analogues (GnRH-a) prior to endometrial ablation has been reported to increase the success rate, as well as to reduce the menstrual blood flow, accounting for a...
journal_title:Gynecologic and obstetric investigation
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journal_title:Gynecologic and obstetric investigation
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doi:10.1159/000292284
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journal_title:Gynecologic and obstetric investigation
pub_type: 临床试验,杂志文章
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journal_title:Gynecologic and obstetric investigation
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doi:10.1159/000291890
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abstract::High linear energy transfer radioisotopes carried by appropriate agents have been proposed for receptor-directed radiotherapy. Two such classes of isotopes are Auger electron and alpha-emitting nuclides. To determine the relative cytotoxicity and nuclear damage to cells produced by these two classes of nuclides, we co...
journal_title:Gynecologic and obstetric investigation
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journal_title:Gynecologic and obstetric investigation
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journal_title:Gynecologic and obstetric investigation
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journal_title:Gynecologic and obstetric investigation
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journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章,随机对照试验
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journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章,评审
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journal_title:Gynecologic and obstetric investigation
pub_type: 临床试验,杂志文章
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journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000331652
更新日期:2012-01-01 00:00:00
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journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000294919
更新日期:2010-01-01 00:00:00
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journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000292671
更新日期:1993-01-01 00:00:00
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journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000075582
更新日期:2004-01-01 00:00:00
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journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000298967
更新日期:1985-01-01 00:00:00
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journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000292545
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journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000292401
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journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000493855
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journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000293698
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journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000293095
更新日期:1991-01-01 00:00:00
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journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000511018
更新日期:2020-01-01 00:00:00
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journal_title:Gynecologic and obstetric investigation
pub_type: 临床试验,杂志文章
doi:10.1159/000316265
更新日期:2010-01-01 00:00:00
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journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章,meta分析,评审
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更新日期:2006-01-01 00:00:00
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journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000323531
更新日期:2011-01-01 00:00:00
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journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
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更新日期:2014-01-01 00:00:00
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journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000114250
更新日期:2008-01-01 00:00:00
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journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000293161
更新日期:1991-01-01 00:00:00