Efficacy and Safety of Hyaluronic Acid Gel for the Prevention of Intrauterine Adhesion: A Meta-Analysis of Randomized Clinical Trials.

Abstract:

BACKGROUND:The aim of this study is to assess the clinical effectiveness and safety of hyaluronic acid gel for the prevention of postoperative intrauterine adhesions (IUAs). METHODS:PubMed, Cochrane Library, Embase and ClinicalTrials.gov databases were searched for randomized controlled trials. RESULTS:Six RCTs with a total of 564 patients met the inclusion criteria. The meta-analysis showed that, compared to no other treatment method, hyaluronic acid gel significantly reduced the rate of any IUA (risk ratio [RR] 0.68; 95% CI 0.53-0.86; p = 0.03; I2 = 64%) and adhesion score (standard mean difference = -2.90; 95% CI -4.61 to -1.49; p < 0.00001; I2 = 98%) following intraperitoneal or intrauterine surgery. Treatment lowered the rate of IUAs classified as moderate (RR 0.26; 95% CI 0.13-0.52; p = 0.13; I2 = 0%), but not those deemed mild (RR 0.86; 95% CI 0.62-1.21; p = 0.39; I2 = 3%) or severe (RR 0.33; 95% CI 0.03-3.09; p = 0.33; I2 = 0). Compliance with hyaluronic acid gel treatment was low. CONCLUSION:Hyaluronic acid gel can prevent IUAs, particularly those with moderate severity and a lower adhesion score.

journal_name

Gynecol Obstet Invest

authors

Liu H,Xu Y,Yi N,Yi W

doi

10.1159/000486674

subject

Has Abstract

pub_date

2018-01-01 00:00:00

pages

227-233

issue

3

eissn

0378-7346

issn

1423-002X

pii

000486674

journal_volume

83

pub_type

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