Abstract:
BACKGROUND:The aim of this study is to assess the clinical effectiveness and safety of hyaluronic acid gel for the prevention of postoperative intrauterine adhesions (IUAs). METHODS:PubMed, Cochrane Library, Embase and ClinicalTrials.gov databases were searched for randomized controlled trials. RESULTS:Six RCTs with a total of 564 patients met the inclusion criteria. The meta-analysis showed that, compared to no other treatment method, hyaluronic acid gel significantly reduced the rate of any IUA (risk ratio [RR] 0.68; 95% CI 0.53-0.86; p = 0.03; I2 = 64%) and adhesion score (standard mean difference = -2.90; 95% CI -4.61 to -1.49; p < 0.00001; I2 = 98%) following intraperitoneal or intrauterine surgery. Treatment lowered the rate of IUAs classified as moderate (RR 0.26; 95% CI 0.13-0.52; p = 0.13; I2 = 0%), but not those deemed mild (RR 0.86; 95% CI 0.62-1.21; p = 0.39; I2 = 3%) or severe (RR 0.33; 95% CI 0.03-3.09; p = 0.33; I2 = 0). Compliance with hyaluronic acid gel treatment was low. CONCLUSION:Hyaluronic acid gel can prevent IUAs, particularly those with moderate severity and a lower adhesion score.
journal_name
Gynecol Obstet Investjournal_title
Gynecologic and obstetric investigationauthors
Liu H,Xu Y,Yi N,Yi Wdoi
10.1159/000486674subject
Has Abstractpub_date
2018-01-01 00:00:00pages
227-233issue
3eissn
0378-7346issn
1423-002Xpii
000486674journal_volume
83pub_type
杂志文章,meta分析abstract::The Special Programme of Research in Human Reproduction (HRP), co-sponsored by the UNDP, UNFPA, WHO, and the World Bank, is celebrating 40 years of activities with an expansion of its mandate and new co-sponsors. When it began, in 1972, the main focus was on evaluating the acceptability, effectiveness, and safety of e...
journal_title:Gynecologic and obstetric investigation
pub_type: 历史文章,杂志文章,评审
doi:10.1159/000343067
更新日期:2012-01-01 00:00:00
abstract::Penis and testicle amputation, vaginoplasty, and clitoroplasty are procedures that help male-to-female transsexuals to accept their body and to increase psychosocial well-being. We describe a successful correction of prolapse of the neovagina with abdominovaginal sacropexy in a male-to-female transsexual who had under...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000064559
更新日期:2002-01-01 00:00:00
abstract::Our purpose was to determine whether intrauterine sonography with high-frequency, real-time miniature transducer (20 MHz) is useful for the diagnosis of gynecologic disorders. The study consisted of 37 women: 8 normal volunteers, 2 with molar pregnancy, 4 fibromyoma, 4 endometrial polyp, 1 intrauterine adhesion, 1 sep...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000010072
更新日期:1999-01-01 00:00:00
abstract::Amniotic fluids from women in West Virginia were evaluated for the presence of antibacterial activity by a bioassay technique. 41% of 32 third trimester samples were inhibitory. Evaluation of additional test organisms emphasized differences in susceptibility of various bacterial strains; two isolates of Escherichia co...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000299390
更新日期:1983-01-01 00:00:00
abstract::The study assessed the agreement in cardiotocogram interpretation between the 2CTG computerized system and experienced and inexperienced observers involved in a telecardiotocography project called 'TOCOMAT'. Both observers and computer analyzed FHR baseline, FHR variability, and number of large accelerations and of de...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000068955
更新日期:2003-01-01 00:00:00
abstract::The present study was undertaken in order to determine the changes in blood levels of lipid peroxide and vitamin E in EPH gestosis. The mean plasma level of lipid peroxide was 0.89 +/- 0.13 nmol/ml for nonpregnant women, while for normal pregnant women it was 2.51 +/- 0.52 nmol/ml, and 4.10 +/- 0.72 nmol/ml for women ...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000292473
更新日期:1994-01-01 00:00:00
abstract::The objective of the study was to assess the effects of low-dose vaginal treatment with oestradiol before vaginal operation. In a double-blind randomized study including 43 postmenopausal women scheduled for vaginal repair operation for genital descensus, it was found that 7 patients suffered from concomitant urinary ...
journal_title:Gynecologic and obstetric investigation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000292320
更新日期:1995-01-01 00:00:00
abstract::By means of bacteriological, histological and immunofluorescence methods, the ascending spread of endocervically inoculated bacteria was studied in 14 pregnant sheep. 8 ewes near term were exposed to group B streptococci, Bacteroides fragilis or Streptococcus intermedius for 2-4 days. 6 other animals in mid pregnancy ...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000299415
更新日期:1983-01-01 00:00:00
abstract:BACKGROUND/AIMS:To evaluate patient satisfaction after laparoscopic supracervical (LASH) or total hysterectomy (TLH). METHODS:Retrospective study of patient satisfaction after LASH or TLH. RESULTS:We studied 40 cases of LASH and another 40 of TLH. The age of the patients, marital status, education level and employmen...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000184679
更新日期:2009-01-01 00:00:00
abstract::The psychological state of 102 infertile women undergoing in vitro fertilization and embryo transfer was investigated. The levels of anxiety were measured by the state trait anxiety inventory and the manifest anxiety scale. The process of accepting infertility and attitudes toward treatment were explored by a semistru...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000291510
更新日期:1997-01-01 00:00:00
abstract::Using a 4-MHz continuous-wave Doppler device, standard rates were established for resistance index (RI) and pulsatility index (PI) of uterine and arcuate arteries of 612 patients with uneventful pregnancies and deliveries. From 18 to 41 weeks of gestation, neither RI nor PI of uterine or arcuate arteries proved to var...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000292732
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND/AIMS:Some embryo implantation problems in patients with recurrent implantation failure may be explained by the inability of the embryo to hatch out of its zona pellucida. In this case-control study, a study group which had received modified quarter laser-assisted zona thinning (mQLAZT) was compared with a co...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000171068
更新日期:2009-01-01 00:00:00
abstract::If we see a young, phenotypically female patient with an XY karyotype, it is of great importance to differentiate between the testicular feminization syndrome and gonadal dysgenesis. Patients with testicular feminization will always have normal testes, which are situated either in the ovarian fossa or in the inguinal ...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000293367
更新日期:1990-01-01 00:00:00
abstract:AIM:To compare the effect of suprapubic and transurethral catheterization on postvoid residual volumes (PRVs) after cystocele repair. METHODS:126 women who underwent pelvic organ prolapse surgery including cystocele repair were randomized to suprapubic or transurethral catheterization. At the third postoperative day, ...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章,随机对照试验
doi:10.1159/000323827
更新日期:2011-01-01 00:00:00
abstract::The effects of bolus injections of 1.0-80.0 micrograms/kg body weight fenoterol on urinary excretion, osmolarity and electrolytes were studied in unanesthetized, water-loaded rabbits. In animals infused initially with isotonic solution over 2 h with 60 ml/h and thereafter over 10 h with 45 ml/h, urine excretion was 53...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000299169
更新日期:1984-01-01 00:00:00
abstract::The histological and ultrastructural features of 15 endometrial carcinomas were analyzed and recorded without knowledge of the steroid receptor content which was determined in the cytosol of the tumor tissue. Serum levels of estrogens were determined in all patients. The importance of this simultaneous determination o...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000299521
更新日期:1982-01-01 00:00:00
abstract:BACKGROUND/AIMS:A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) enzymes take part in extracellular matrix (ECM) remodeling which has been shown to contribute to the ovulation and follicular functions. We aimed to compare serum levels of ADAMTS-19 in patients with different fertility situations. ...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000490665
更新日期:2019-01-01 00:00:00
abstract::Treatment of endometriosis with gonadotropin-releasing hormone agonists (GnRHa) is limited to 6 months because of possible adverse effects on bone metabolism. We designed a randomized, double-blind, placebo-controlled, prospective study of 27 patients with endometriosis who were given GnRHa with or without hormone add...
journal_title:Gynecologic and obstetric investigation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000010059
更新日期:1999-01-01 00:00:00
abstract:BACKGROUND/AIMS:Previous studies on the effects of estrogen on sclerostin regulation were conducted in postmenopausal women in humans or animals following estrogen treatment or induced estrogen deficiency. The aim of this study was to evaluate the effects of sex hormones on serum sclerostin levels in premenopausal wome...
journal_title:Gynecologic and obstetric investigation
pub_type: 临床试验,杂志文章
doi:10.1159/000347013
更新日期:2013-01-01 00:00:00
abstract::Scanning electron microscopy of cryofractured immature intermediate villi showed numerous intercommunicating channels in the central region of the stroma, oriented mostly parallel to the major axis of the villus. In the stromal channels, numerous Hofbauer cells were present and their aspect and position inside the cha...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000299056
更新日期:1984-01-01 00:00:00
abstract::A suburethral sling procedure using a Mersilene mesh has been performed in 24 patients. Six patients had recurrent incontinence after an unsuccessful past operation. A postoperative follow-up was done for an average of 24 months. Twenty-three patients were free of symptoms, while only 1 patient had recurrent incontine...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000292521
更新日期:1994-01-01 00:00:00
abstract::In order to investigate the effect of hormone replacement therapy (HRT) on plasma homocysteine and C-reactive protein (CRP) levels 46 healthy postmenopausal women were prospectively enrolled. HRT, which was either 0.625 mg/day conjugated equine estrogen (CEE) plus 2.5 mg/day medroxyprogesterone acetate (MPA) or 0.625 ...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000049412
更新日期:2002-01-01 00:00:00
abstract::A prospective randomized trial comprising 90 patients was undertaken to evaluate three different regimens of tinidazole in the treatment of anaerobic vaginosis. Each group consisted of 30 women. The three regimens were: (A) oral tinidazole (150 mg X 2) for 7 days, (B) same oral treatment as above but also the partner ...
journal_title:Gynecologic and obstetric investigation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000293524
更新日期:1989-01-01 00:00:00
abstract::This study was conducted in order to investigate the usefulness of granulocyte elastase levels as predictive factors in the onset of perinatal infections. The subjects were 41 patients who delivered within 48 h after amniocentesis after giving their informed consent. The relationship between cervical granulocyte elast...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000292401
更新日期:1995-01-01 00:00:00
abstract:AIMS:To investigate misoprostol use as a self-administered medical abortifacient and to explore the knowledge and availability of misoprostol and attitudes towards it among Saudi women. METHODS:A questionnaire-based cross-sectional study was conducted in obstetric and gynecological outpatient clinics at private and te...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000363238
更新日期:2014-01-01 00:00:00
abstract::The aim of this study was to present our preliminary data about nasal bone measurements at 11-14 weeks of pregnancy. This study was conducted in our prenatal unit between 2000 and 2003. A total of 642 pregnant women (single pregnancies) were enrolled into the study. During the first trimester of pregnancy, crown-rump ...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000078499
更新日期:2004-01-01 00:00:00
abstract:AIM:The objective of the present study was to investigate the development of mouse embryos and the chromosomal status after the pre-implantation treatment with paclitaxel (Taxol) based on the reports that indicate Taxol improves the developmental potential of vitrified human and mouse oocytes. METHODS:Outbred female m...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000502820
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Dyslipidemia is commonly observed in polycystic ovary syndrome (PCOS) patients. Bezafibrate is a drug for dyslipidemia acting through peroxisome proliferator-activated receptors. We investigated the effects of bezafibrate for ovulation induction in patients with PCOS with dyslipidemia who were resistant to c...
journal_title:Gynecologic and obstetric investigation
pub_type: 临床试验,杂志文章
doi:10.1159/000316265
更新日期:2010-01-01 00:00:00
abstract::The ovarian morphology in 149 patients with the clinical syndrome of polycystic ovaries (group I) is described. The ovaries from 10 age-matched women (group II) with no signs of ovarian disorder were investigated as a reference material. The number of cysts documented for group I was twice that of the reference group ...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000293771
更新日期:1988-01-01 00:00:00
abstract::We report an extremely rare case of a 50-year-old woman with an adenocarcinoma arising within a urethral diverticulum. She could not be diagnosed correctly before operation and the microscopic pathological examination of the surgical specimen was the only indication showing the cancer origin. ...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000292307
更新日期:1995-01-01 00:00:00