Clinical effects of preoperative oestradiol treatment before vaginal repair operation. A double-blind, randomized trial.

Abstract:

:The objective of the study was to assess the effects of low-dose vaginal treatment with oestradiol before vaginal operation. In a double-blind randomized study including 43 postmenopausal women scheduled for vaginal repair operation for genital descensus, it was found that 7 patients suffered from concomitant urinary stress incontinence. Vagifem (25 micrograms oestradiol) or placebo was administered as vaginal pessaries daily, 3 weeks prior to surgery and the clinical effects evaluated. One month postoperatively the prevalence of bacteriuria (> 100,000 CFU/ml urine) was significantly lower when using oestradiol than in the placebo group. At follow-up 3 years later 40 women (93%) answered the questionnaires. None received hormone replacement therapy. Nineteen percent in the preoperative oestradiol group and 11% in the preoperative placebo group had had more than two episodes of cystitis treated with antibiotics. This difference is not statistically significant (p > 0.05). Recurrent cystitis was not correlated to bacteriuria postoperatively. Seventy-nine percent of the women with genital prolapse but only 29% of the women with concomitant urinary stress incontinence were cured (p < 0.05). Neither preoperative oestradiol treatment nor body weight had any influence on relapse. Preoperative low-dose vaginal oestradiol treatment may reduce the incidence of bacteriuria in the immediate postoperative period but no long-lasting effects on recurrent cystitis or relapse were seen. Longer-lasting hormone replacement therapy may be necessary to achieve lasting effects.

journal_name

Gynecol Obstet Invest

authors

Mikkelsen AL,Felding C,Clausen HV

doi

10.1159/000292320

subject

Has Abstract

pub_date

1995-01-01 00:00:00

pages

125-8

issue

2

eissn

0378-7346

issn

1423-002X

journal_volume

40

pub_type

临床试验,杂志文章,随机对照试验
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    abstract::Connective tissue of human ovarian capsule with polycystic ovarian disease (PCO) is analyzed. The connective tissue components of the capsule were found to mainly consist of type I collagen and acid glycosaminoglycans, such as dermatan sulfate, heparan sulfate, and chondroitin 4- and 6-sulfate. Although their concentr...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000299089

    authors: Mori Y,Hasumi F,Ito A,Shiina K,Hirakawa S

    更新日期:1984-01-01 00:00:00

  • Vacuum aspiration at therapeutic abortion: blood loss at operation in multigravid women.

    abstract::Therapeutic abortion by vacuum aspiration in the first trimester was carried out on 129 healthy multigravid women. The loss of haemoglobin at operation was estimated and the volume of blood calculated. The figures were compared to those in a group of primigravid women earlier reported. Blood loss increases with gestat...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000300997

    authors: Sandström B,Segerbrand E,Solheim F

    更新日期:1978-01-01 00:00:00

  • Etiology of serum CA-125 in patients with endometriosis treated with a gonadotrophin-releasing hormone agonist (Buserelin).

    abstract::Fifty-six patients with pelvic endometriosis were treated with a buserelin dosage of 200 micrograms/day s.c. for 6 months. Scoring of the American Fertility Society (AFS) for endometriosis was performed by laparoscopy in all cases before and at the end of therapy. Serum CA-125 and estradiol levels were determined befo...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000292491

    authors: Cetin T,Vardar MA,Demir C,Burgut R

    更新日期:1994-01-01 00:00:00

  • Compensatory mechanisms which prevent urinary incontinence in aging women.

    abstract::The relationship between age and urodynamic parameters was studied cross-sectionally in a group of 28 women in whom clinically and urodynamically both stress incontinence and detrusor instability were excluded (no proven incontinence, NPI) and in a group, matched for age, with genuine stress incontinence (GSI). At all...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000294858

    authors: Wijma J,Tinga DJ,Visser GH

    更新日期:1992-01-01 00:00:00

  • Single-Incision Mini-Slings: Obturator Complex Pull-Out-Force Measurements.

    abstract:AIM:To evaluate the different pull-out-force out of the obturator membrane and the obturator internus muscle of 2 mini-sling systems for stress urinary incontinence (SUI) treatment. MATERIAL AND METHODS:In a prospective study, the pull-out-force measurements were performed on 8 female cadaver pelvises, both on the obt...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000449156

    authors: Lenz F,Doll S,Sohn C,Brocker KA

    更新日期:2017-01-01 00:00:00

  • Fimbrio-ovarian relationship in unexplained infertility.

    abstract:INTRODUCTION:The role of defective fimbrio-ovarian relation in cases of unexplained infertility has not been extensively studied. The aim of the study was to assess the role of fimbrio-ovarian relation as an investigative modality in women with unexplained infertility. We also aimed to evaluate the efficacy of superovu...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000086004

    authors: Roy KK,Hegde P,Banerjee K,Malhotra N,Nayyar B,Deka D,Kumar S

    更新日期:2005-01-01 00:00:00

  • Continuous, high-dose progestogen treatment of endometrial cancer.

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    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000298812

    authors: Szarvas Z,Zsolnai B,Gimes G,Hidvégi J

    更新日期:1987-01-01 00:00:00

  • Repeat abortion and contraceptive use. Report from an Interview Study in Stockholm.

    abstract::Semistructured interviews were made among a random sample of applicants for abortion in Stockholm, when legal abortion on demand had been available in Sweden for 10 years. One hundred and twenty women were interviewed, 75 of them having their first abortion and 45 having a repeat abortion. The use of contraceptives wa...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000292572

    authors: Holmgren K

    更新日期:1994-01-01 00:00:00

  • Mixed clear cell and endometrioid carcinoma arising in parietal endometriosis.

    abstract:AIM:We report a case of a mixed clear cell and endometrioid carcinoma arising in parietal endometriosis. METHODS:A 46-year-old woman presented a second recurrence of parietal endometriosis. An extensive surgical resection of the tumor was then carried out. RESULTS:Histological analysis revealed heterogeneous tissues ...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000096437

    authors: Razzouk K,Roman H,Chanavaz-Lacheray I,Scotté M,Verspyck E,Marpeau L

    更新日期:2007-01-01 00:00:00

  • Ureteral blockage as a complication of Burch colposuspension: report of 6 cases.

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    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000293398

    authors: Ferriani RA,Silva de Sá MF,Dias de Moura M,Charaffedine MN,Hockgreb de Freitas Júnior A

    更新日期:1990-01-01 00:00:00

  • Accuracy of frozen section diagnosis in borderline ovarian malignancy.

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    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000010244

    authors: Kayikçioglu F,Pata O,Cengiz S,Tulunay G,Boran N,Yalvaç S,Köse MF

    更新日期:2000-01-01 00:00:00

  • Postoperative depot medroxyprogesterone acetate versus continuous oral contraceptive pills in the treatment of endometriosis-associated pain: a randomized comparative trial.

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    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章,随机对照试验

    doi:10.1159/000337713

    authors: Cheewadhanaraks S,Choksuchat C,Dhanaworavibul K,Liabsuetrakul T

    更新日期:2012-01-01 00:00:00

  • Effect of an aromatase inhibitor in human follicular fluid on DNA synthesis of granulosa cells, theca cells, and follicles.

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    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000292692

    authors: Ono T,Komiya Y,Kawagoe SN,Hiroi M

    更新日期:1993-01-01 00:00:00

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    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000071525

    authors: Drieskens O,Stroobants S,Gysen M,Vandenbosch G,Mortelmans L,Vergote I

    更新日期:2003-01-01 00:00:00

  • Health professionals' opinions regarding abortions and the abortion law in samples from Italy and Sweden.

    abstract::The present study was undertaken to investigate the opinions of health professionals working in family planning clinics in Italy and Sweden. The comparison of two such different countries seemed of interest both to describe differences and/or similarities between the samples as well as to analyze factors that could in...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000293118

    authors: Agostino MB,De Marinis MG,Wahlberg V

    更新日期:1991-01-01 00:00:00

  • Adrenoceptor function in female genital tract.

    abstract::The function of adrenoceptors in the female genital tract was tested estimating the uptake of 3H-noradrenaline (3H-NA) in vitro in oviductal, uterine arterial and myometrial tissue samples obtained from 74 women. The highest 3H-NA value, 64 +/- 5 ng/g, was in the oviduct (p less than 0.001 vs. uterine artery and myome...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000293673

    authors: Saarikoski S

    更新日期:1988-01-01 00:00:00

  • Prostacyclin does not influence placental blood pool in vivo.

    abstract::In 20 healthy pregnant women placental blood pool was estimated by means of placental scintigrams before, during and after infusion of either prostacyclin (PGI2) or placebo for 10 min to study the effect of PGI2 on the local regulation of uterine blood flow. There was no difference in the mean number of counts between...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 临床试验,杂志文章

    doi:10.1159/000299012

    authors: Husslein P,Gitsch E,Pateisky N,Philipp K,Leodolter S,Sinzinger H

    更新日期:1985-01-01 00:00:00

  • Fetal circulatory responses to maternal blood loss.

    abstract::We examined the fetal circulatory responses to maternal blood loss in pregnant women during the third trimester. Seven healthy women with placenta previa and singleton pregnancies underwent phlebotomies in an autologous donation program. Four hundred milliliters of blood was collected within 15 min at 34 and 35 weeks ...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000052915

    authors: Suzuki S,Tateoka S,Yagi S,Ishikawa G,Ohshita T,Sawa R,Yoneyama Y,Asakura H,Araki T

    更新日期:2001-01-01 00:00:00

  • Diagnostic aid of endometrium biopsy.

    abstract::The 784 cases, from which 701 complained of abnormal uterine bleeding, were reviewed by age groups, presenting symptoms, sex steroid medication and endometrial findings. Endometrial polyps and endometritis, which showed an incidence of 17.5 and 10.0%, respectively, were correlated with clinicopathologic findings. Peri...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000299980

    authors: van Bogaert LJ

    更新日期:1979-01-01 00:00:00

  • Evaluation of a new portable system for cord lactate determination.

    abstract::To evaluate a new reflectance photometer (Accusport) for blood lactate determination, a prospective non-interventional study was performed on blood obtained from the umbilical cord artery immediately after delivery of the baby in 109 consecutive women. For each sample, the results of cord arterial blood lactate values...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000009919

    authors: Yam J,Chua S,Razvi K,Arulkumaran S

    更新日期:1998-01-01 00:00:00

  • Can a low-lying placenta be the risk factor of cervical incompetence? A preliminary study on the relationship between placenta insertion and anatomical status of uterine cervix.

    abstract::An attempt was made to verify the hypothesis that a low-lying placenta may be a factor leading to the dynamic form of cervical incompetence. A vaginal evaluation of the cervix was made in 143 pregnant women who by means of ultrasonographic method were found to have low-lying placentas. In as many as 68 out of the 143 ...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000298964

    authors: Uszyński M,Majczyński T,Uszyński W

    更新日期:1985-01-01 00:00:00

  • Plasma endothelin-1 levels during asphyxia in the fetal goat.

    abstract::The changes in fetal carotid arterial plasma levels of endothelin-1, catecholamines, PO2, PCO2 and pH were measured after intermittent repetitive umbilical cord occlusion in late gestation pregnant goats (n = 9). Endothelin-1 levels increased to 3.58 +/- 0.28 pg/ml immediately after the onset of fetal hypoxia, a level...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000291966

    authors: Takada H,Yoneyama Y,Power GG,Araki T

    更新日期:1996-01-01 00:00:00

  • Usefulness of bezafibrate for ovulation induction in clomiphene citrate-resistant polycystic ovary syndrome patients with dyslipidemia: a prospective pilot study of seven cases.

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    journal_title:Gynecologic and obstetric investigation

    pub_type: 临床试验,杂志文章

    doi:10.1159/000316265

    authors: Hara S,Takahashi T,Amita M,Igarashi H,Kurachi H

    更新日期:2010-01-01 00:00:00

  • Monochorionic triplets following intracytoplasmic sperm injection: a report of two consecutive cases.

    abstract::Monochorionic triplet pregnancies are very rare. Here we report 2 cases of multiple pregnancies with monochorionic triplets following intracytoplasmic sperm injection (ICSI) and day 3 embryo transfer. The 2 women concomitantly underwent controlled ovarian hyperstimulation due to male factor infertility. Following oocy...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000076786

    authors: Ulug U,Jozwiak EA,Mesut A,Bener F,Bahceci M

    更新日期:2004-01-01 00:00:00

  • Proteoglycans from cultures of fibroblast from the human uterine cervix.

    abstract::A small dermatan sulphate proteoglycan has been isolated from the human uterine cervix. The concentration of this proteoglycan has been shown to decrease during pregnancy. To study the mechanism behind this change fibroblasts from the human uterine cervix were established in culture. Their synthesis and secretion of p...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000299026

    authors: Uldbjerg N,Malmström A,Ekman G,Ulmsten U

    更新日期:1985-01-01 00:00:00

  • Mechanically induced tube damage in the artificial hydrosalpinx.

    abstract::One-sided artificial hydrosalpinx was caused in mature New Zealand rabbits by proximal and distal ligature. After 2 weeks the average secretion accumulation was 2.1 ml, after 8 weeks 6.3 ml. A fold relief could no longer be detected after 8 weeks. The light-microscopical study of the epithelium showed signs of cell de...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000299469

    authors: Kleinstein J,Neubüser D,Mussmann J

    更新日期:1982-01-01 00:00:00

  • Intrauterine resuscitation in the severely distressed fetal dog.

    abstract::Severe fetal distress was produced in 16 fetal dogs by successive and/or prolonged occlusion of the maternal abdominal aorta in an acute surgical preparation, and was characterized in fetal arterial blood of 7.06 for pH, 10 mm Hg for O2, 127 mm Hg for CO2, and fetal heart rate decelerations. Five fetuses recovered spo...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000294837

    authors: Abitbol MM,Monheit AG,Guzman E

    更新日期:1992-01-01 00:00:00

  • Common genetic changes between endometriosis and ovarian cancer.

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    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章,评审

    doi:10.1159/000052877

    authors: Obata K,Hoshiai H

    更新日期:2000-01-01 00:00:00

  • Fetal heart rate decelerations precede a decrease in fetal oxygen content.

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    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000291404

    authors: Izumi A,Minakami H,Sato I

    更新日期:1997-01-01 00:00:00

  • Clinical and prognostic significance of human papillomavirus in a Chinese population of cervical cancers.

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    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000052925

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    更新日期:2001-01-01 00:00:00