Abstract:
:This review summarizes the existing evidence regarding intrauterine insemination (IUI) as a treatment for cervical hostility, male and unexplained subfertility. IUI in natural cycles has been proven effective in patients with cervical hostility and moderate male subfertility. IUI in cycles with mild ovarian hyperstimulation (MOH) should be the treatment of choice in couples with mild male subfertilty (average total motile sperm count above 10 million) and unexplained subfertilty. When MOH is applied, gonadotropins have been proven more effective compared with clomiphene citrate. Further large trials comparing clomiphene citrate with gonadotropins are mandatory. Prevention of multiple pregnancies in MOH/IUI programs is of paramount importance. A strategy with a low-dose step-up protocol and strict cancellation criteria is proposed. When multiple pregnancies are kept to a minimum, MOH/IUI is more cost-effective compared with in vitro fertilization and embryo transfer. Future research should focus on prediction models to predict the outcome of MOH/IUI treatment for individual couples before starting treatment.
journal_name
Gynecol Obstet Investjournal_title
Gynecologic and obstetric investigationauthors
Cohlen BJdoi
10.1159/000080492keywords:
subject
Has Abstractpub_date
2005-01-01 00:00:00pages
3-13issue
1eissn
0378-7346issn
1423-002Xpii
80492journal_volume
59pub_type
杂志文章,评审abstract:OBJECTIVE:To evaluate the efficacy of depot medroxy progesterone acetate (DMPA) as a preparatory agent for endometrial resection. STUDY DESIGN:Endometrial resection was performed on 50 women for excessive uterine bleeding. The patients were randomly divided into 2 equal groups, with the first group receiving DMPA and ...
journal_title:Gynecologic and obstetric investigation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000052969
更新日期:2001-01-01 00:00:00
abstract:OBJECTIVE:To determine the effects of the nitric oxide (NO) precursor L-arginine on the airway NO concentration in patients with preeclampsia. METHODS:NO was measured by a noninvasive chemiluminescence technique in air sampled directly from nasal and oral cavities during expiration before and during L-arginine infusio...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000010040
更新日期:1998-01-01 00:00:00
abstract::Twenty-four women with second-trimester cervical incompetence underwent emergency cerclage. The appropriateness of cervical cerclage was analyzed according to a scoring system (Cervical Incompetence Scale; CIS) which measures the degree of cervical effacement, cervical dilatation and protrusion of fetal membranes into...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000293093
更新日期:1991-01-01 00:00:00
abstract::The measurement of the tissue concentrations of cyclic adenosine monophosphate (cAMP) in human endometrium shows that the levels of the nucleotide vary during the menstrual cycle, being 11.4 +/- (SE) 2.5 and 37.7 +/- (SE) 10.1 pmol/mg protein in the proliferative and secretory phase, respectively. The individual deter...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000299076
更新日期:1984-01-01 00:00:00
abstract:BACKGROUND/AIMS:Adenomyosis is a common condition with a poorly understood pathogenesis. Recent data suggest that it may be an epigenetic disease. This study investigated the expression and localization of class I histone deacetylases (HDACs) in women with and without adenomyosis. METHODS:The ectopic and homologous eu...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000336409
更新日期:2012-01-01 00:00:00
abstract::Cervico-oculo-acousticus syndrome is a very rare entity with only 21 cases described in the world literature. A study of a case of this syndrome with pregnancy is presented. This primigravida, in addition to the classical triad of the syndrome, had other dysmorphic features such as short stature (141 cm), and marked t...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000293115
更新日期:1991-01-01 00:00:00
abstract::The efficacy of three protocols of endometrial preparation (spontaneous cycles, A: artificial preparation, B; ovarian stimulation, C) for cryopreserved-thawed human embryo transfer (CT-ET). The implantation and clinical pregnancy rates per cycle in 236 women undergoing 381 consecutive CT-ETs were evaluated according t...
journal_title:Gynecologic and obstetric investigation
pub_type: 临床试验,杂志文章
doi:10.1159/000292274
更新日期:1996-01-01 00:00:00
abstract:BACKGROUND/AIMS:The transmembrane protein dystroglycan (DG) is known to anchor the cell membrane to the extracellular matrix, and is susceptible to cleavage by matrix metalloproteinases. This study tested the hypothesis that changes in DG abundance in fetal membranes (FM) occur late in gestation, with spontaneous ruptu...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000367894
更新日期:2015-01-01 00:00:00
abstract::A decade of perinatal audit in the Maputo Central Hospital is reviewed with the objective of addressing the potential value of the audit process in monitoring the different constituents of morbidity and mortality in the perinatal period. The perinatal mortality showed a significant but transient change during the obse...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000292637
更新日期:1993-01-01 00:00:00
abstract::Hot flushes are the commonest symptom induced by gonadotropin-releasing hormone agonists (GnRHa). We performed an open observational trial to evaluate the efficacy of veralipride, an antidopaminergic drug, in reducing hot flushes in 25 premenopausal women treated with a GnRHa for endometriosis (8 subjects) or menorrha...
journal_title:Gynecologic and obstetric investigation
pub_type: 临床试验,杂志文章
doi:10.1159/000292736
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:Radiation therapy is a mainstay in the treatment of cervical cancer. However, most advanced and metastatic cervical cancers are resistant to radiation therapy because of the presence of cancer stem cells (CSCs). To date, no specific markers were found for cervical CSCs. METHODS:The fraction of CD44+/CD24+ c...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000493129
更新日期:2019-01-01 00:00:00
abstract::A prospective randomized trial comprising 90 patients was undertaken to evaluate three different regimens of tinidazole in the treatment of anaerobic vaginosis. Each group consisted of 30 women. The three regimens were: (A) oral tinidazole (150 mg X 2) for 7 days, (B) same oral treatment as above but also the partner ...
journal_title:Gynecologic and obstetric investigation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000293524
更新日期:1989-01-01 00:00:00
abstract::Maternal heart rate variability was evaluated by means of 24-hour Holter ECG monitoring in three groups of patients (15 preeclamptic, 15 women hospitalized due to other complications and 15 normal ambulatory pregnant women) in the 28th-33rd week of gestation. Heart rate variability was estimated by time and frequency ...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000009949
更新日期:1998-01-01 00:00:00
abstract::In vitro production of progesterone and estradiol by human corpora lutea of different ages was evaluated in the presence or absence of human chorionic gonadotrophin (HCG). Progesterone production by the luteal tissue was enhanced by as little as 0.1 IU/ml HCG and maximally stimulated by approximately 10 IU/ml HCG. Est...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000293698
更新日期:1988-01-01 00:00:00
abstract:AIM:To develop a magnetic resonance (MR)-visible mesh using iron oxides and prove visibility. METHODS:In a phantom study, a suitable iron oxide, Fe3O4 [iron(II,III) oxide] and FeOOH [iron(III) oxide-hydroxide], concentration was determined using relaxometric MR measurements of the transverse relaxation rates R2 and R2...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000366442
更新日期:2015-01-01 00:00:00
abstract::The essential metal copper, zinc and iron content in starved virgin and pregnant rat tissue has been studied. The copper content of the whole rat, which was actually increased in pregnant rats, decreased in starved pregnant rats. The differences were significant in 19-day pregnant rats. The total copper content of the...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000293737
更新日期:1988-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the antenatal screening of aberrant umbilical vessels and assess the association of fetal abnormality with these entities. STUDY DESIGN:444 pregnant women were studied with routine obstetric ultrasound and Doppler color flow imaging in late second trimester or early third trimester. Fetal growth ...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000291863
更新日期:1997-01-01 00:00:00
abstract::We analyzed 81 ovarian cancers for loss of heterozygosity (LOH) on 10q23 and for mutations in PTEN. LOH was common among the endometrioid (43%) and serous (28%) cancers, but was infrequent among the other histological subtypes. Somatic PTEN mutations were detected in seven (21%) endometrioid cancers and the mutation i...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章,评审
doi:10.1159/000052877
更新日期:2000-01-01 00:00:00
abstract::Tubal occlusion using Filshie clip is one of the most commonly performed operations for female sterilization. It is usually a simple and safe procedure, and operative complications are uncommon. We report a rare case of spontaneous expulsion of a Filshie clip through the anterior abdominal wall 5 years after steriliza...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章,评审
doi:10.1159/000070615
更新日期:2003-01-01 00:00:00
abstract::A suburethral sling procedure using a Mersilene mesh has been performed in 24 patients. Six patients had recurrent incontinence after an unsuccessful past operation. A postoperative follow-up was done for an average of 24 months. Twenty-three patients were free of symptoms, while only 1 patient had recurrent incontine...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000292521
更新日期:1994-01-01 00:00:00
abstract::Among angiogenic factors, VEGF secreted from activated macrophages under the influence of ovarian steroids, IL-8 expressed in endometrial stromal cells, and basic FGF expressed in endometriotic tissue and PD-ECGF expressed in lining epithelial cells independently of the sex steroidal milieu might contribute to the cha...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章,评审
doi:10.1159/000052864
更新日期:1999-01-01 00:00:00
abstract::We propose a new scoring system for intrauterine adhesions (IUA) that may predict the prognosis after hysteroscopic adhesiolysis. We analyzed hysteroscopic findings and clinical data of patients diagnosed as having IUA by reviewing previously published hysteroscopic classifications of IUA. The data were subjected to e...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000010305
更新日期:2000-01-01 00:00:00
abstract::Haptoglobin (Hp) possesses many functions in the immune system and angiogenesis as well as scavenging released hemoglobin, and thus it is speculated that Hp may also play a critical role in the reproductive process. To investigate the possible involvement of Hp in the outcome of in vitro fertilization and embryo trans...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000058053
更新日期:2001-01-01 00:00:00
abstract:AIM:The aim of this study was to evaluate whether natural fertility is related to serum 25-hydroxyvitamin D (25-OH-vitamin D) levels. METHODS:A nested case-control study was designed from a prospective cohort of pregnant women undergoing first trimester screening for aneuploidies. Cases included women seeking pregnanc...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000443397
更新日期:2016-01-01 00:00:00
abstract::The present study was undertaken in order to determine the changes in blood levels of lipid peroxide and vitamin E in EPH gestosis. The mean plasma level of lipid peroxide was 0.89 +/- 0.13 nmol/ml for nonpregnant women, while for normal pregnant women it was 2.51 +/- 0.52 nmol/ml, and 4.10 +/- 0.72 nmol/ml for women ...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000292473
更新日期:1994-01-01 00:00:00
abstract::We report the third case of a prenatal diagnosis of Larsen's syndrome, which is the first report affecting both a 37-year-old primiparous caucasian woman and her fetus not considered to have Larsen's syndrome until the finding of bilateral clubfeet was demonstrated on screening ultrasound at 23 weeks of gestation. His...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000010050
更新日期:1998-01-01 00:00:00
abstract:OBJECTIVE:To determine whether, in addition to treatment with antibiotics, it is necessary to remove the intrauterine device (IUD) to eliminate genital colonization by Actinomyces. METHODS:A randomized clinical trial was carried out. Patients were divided into two groups. The intervention group did not have their IUDs...
journal_title:Gynecologic and obstetric investigation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000052955
更新日期:2001-01-01 00:00:00
abstract::We report an extremely rare case of a 50-year-old woman with an adenocarcinoma arising within a urethral diverticulum. She could not be diagnosed correctly before operation and the microscopic pathological examination of the surgical specimen was the only indication showing the cancer origin. ...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000292307
更新日期:1995-01-01 00:00:00
abstract::It is recognised that there is a non-reactive status in the maternal immune system during normal pregnancy as it fails to recognise the fetus which is an allograft. The present study was aimed to understand the nature of cell-mediated immune response and the presence of immunosuppressive factors during human pregnancy...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000294838
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND/AIMS:Dyslipidemia is common in women with polycystic ovary syndrome (PCOS) irrespective of age. Our aim was to investigate soluble tumor necrosis factor like weak inducer of apoptosis (sTWEAK), a cardiovascular risk marker in PCOS, and to determine if it is associated with dyslipidemia in youth. METHODS:A p...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000447590
更新日期:2017-01-01 00:00:00