Postmenopausal hormone replacement therapy use decreases oxidative protein damage.

Abstract:

OBJECTIVES:The aim of this study is to evaluate oxidative protein damage (OPD) by investigating protein carbonyl (PCO) and nitrotyrosine (NT) levels, oxidative stress by total thiol (T-SH), erythrocyte glutathione (GSH) and nitric oxide (NO) levels in women receiving hormone replacement therapy (HRT). MATERIALS AND METHODS:To examine the influence of oxidative stress on OPD, we studied 12 postmenopausal women who had received HRT for 6 months, and 13 postmenopausal women who did not receive HRT, as the control group. All subjects were non-smokers. Blood samples were drawn in the fasting state and processed within 1 h of collection. For NT and NO, serum samples were stored at -70 degrees C until analysis; all other parameters were determined on the same day of collection. RESULTS:After 6 months, plasma PCO and T-SH levels were decreased, GSH and NO levels were increased, and NT levels were not changed in 12 postmenopausal women receiving HRT. Except the NT levels, the rest of the parameters did not significantly change in the control group. Interestingly, mean NT levels in the control group increased significantly. CONCLUSIONS:A crucial part of the protective effect of HRT on the cardiovascular system arises secondary to the interaction between estrogen and vessel wall. Our results suggest that an important component of the mechanism underlying this interaction may depend on estrogen's antioxidant effect and its preventive role in OPD.

journal_name

Gynecol Obstet Invest

authors

Telci A,Cakatay U,Akhan SE,Bilgin ME,Turfanda A,Sivas A

doi

10.1159/000067718

keywords:

subject

Has Abstract

pub_date

2002-01-01 00:00:00

pages

88-93

issue

2

eissn

0378-7346

issn

1423-002X

pii

67718

journal_volume

54

pub_type

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