Abstract:
:Alleviation of infertility on the one hand and development of improved methods of contraception on the other are global concerns to woman's health. The molecular signals that regulate implantation are of clinical relevance since understanding the nature of these signals may lead to strategies to correct implantation failure and to develop novel contraceptive approaches. The other pressing concern is the poor pregnancy rate resulting from in vitro fertilization (IVF). The pregnancy rate in IVF programs remains about 20-30% in spite of the high rate of successful fertilization. This has led to the proposition that additional uterine factors, critical for the implantation process, must be limiting. Identification of such parameters could help in determining the appropriate physiological state of the uterus for embryo transfer. Several factors are known to have a direct or indirect impact on the ability of the uterus to develop to a functionally receptive state. This would disrupt the normal coordination between embryonic and uterine development even though all molecular players may seem otherwise normal.
journal_name
Gynecol Obstet Investjournal_title
Gynecologic and obstetric investigationauthors
Deb K,Chatturvedi MM,Jaiswal YKdoi
10.1159/000076761keywords:
subject
Has Abstractpub_date
2004-01-01 00:00:00pages
224-32issue
4eissn
0378-7346issn
1423-002Xpii
76761journal_volume
57pub_type
杂志文章,评审abstract::Concentrations of leukotriene B4 (LTB4) and prostaglandin E2 (PGE2) in peritoneal fluid were measured in 19 women with suspected acute pelvic inflammatory disease. Acute salpingitis was verified by laparoscopy in 16 cases; 11 of them had isolation of microbes from the peritoneal cavity. Means (+/- SD) levels of perito...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000293338
更新日期:1990-01-01 00:00:00
abstract::The effect of the moon on the number of newborns has been investigated extensively with contradictory results but with few significant findings. In this paper, a possible lunar effect is analyzed by a nonlinear Poisson regression model similar to a Fourier analysis based on all children (n = 2,760,362) born in Austria...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000052999
更新日期:2002-01-01 00:00:00
abstract::In 15 normal mothers the stress effects of labor on zinc and copper distributions in erythrocytes and plasma were investigated. Lower levels of total zinc and of zinc derived from both carbonic anhydrase isoenzymes (CA-I and CA-II), especially from CA-I, in erythrocytes were obtained immediately after delivery. On the...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000298798
更新日期:1987-01-01 00:00:00
abstract::The psychological state of 102 infertile women undergoing in vitro fertilization and embryo transfer was investigated. The levels of anxiety were measured by the state trait anxiety inventory and the manifest anxiety scale. The process of accepting infertility and attitudes toward treatment were explored by a semistru...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000291510
更新日期:1997-01-01 00:00:00
abstract::Women with polycystic ovary syndrome (PCOS) have several cardiovascular disease risk factors. Since hyperhomocysteinemia is associated with early atherosclerosis, it was postulated that the homocysteine levels are higher in PCOS patients than in control subjects which, therefore, may explain the cardiovascular disease...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000058367
更新日期:2002-01-01 00:00:00
abstract::If we see a young, phenotypically female patient with an XY karyotype, it is of great importance to differentiate between the testicular feminization syndrome and gonadal dysgenesis. Patients with testicular feminization will always have normal testes, which are situated either in the ovarian fossa or in the inguinal ...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000293367
更新日期:1990-01-01 00:00:00
abstract::Gestational diabetes (GD), defined as carbohydrate intolerance with onset or first recognition during pregnancy, has a prevalence of 7% and is a growing problem worldwide. Infants born to mothers with GD are more likely to be large for gestational age, incur traumatic birth injury, require a stay in the intensive care...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章,评审
doi:10.1159/000357616
更新日期:2014-01-01 00:00:00
abstract::Plasma digoxin-like immunoreactive factor (DLIF) has been detected in various pathophysiological conditions associated with volume expansion. In this study, using radioimmunoassay, we confirmed the existence of high levels of DLIF in the stimulated follicular fluid, a rapidly volume-expanding biological model. The con...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000293029
更新日期:1991-01-01 00:00:00
abstract::In vitro production of progesterone and estradiol by human corpora lutea of different ages was evaluated in the presence or absence of human chorionic gonadotrophin (HCG). Progesterone production by the luteal tissue was enhanced by as little as 0.1 IU/ml HCG and maximally stimulated by approximately 10 IU/ml HCG. Est...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000293698
更新日期:1988-01-01 00:00:00
abstract:AIMS:To investigate misoprostol use as a self-administered medical abortifacient and to explore the knowledge and availability of misoprostol and attitudes towards it among Saudi women. METHODS:A questionnaire-based cross-sectional study was conducted in obstetric and gynecological outpatient clinics at private and te...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000363238
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND/AIMS:To determine whether genetic alterations in the CD9 gene are associated with female infertility in humans. METHODS:We sequenced the entire coding region of this gene in 86 Japanese women with unexplained infertility and further conducted a case-control study of six tagging single nucleotide polymorphis...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000262451
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:Dyslipidemia is commonly observed in polycystic ovary syndrome (PCOS) patients. Bezafibrate is a drug for dyslipidemia acting through peroxisome proliferator-activated receptors. We investigated the effects of bezafibrate for ovulation induction in patients with PCOS with dyslipidemia who were resistant to c...
journal_title:Gynecologic and obstetric investigation
pub_type: 临床试验,杂志文章
doi:10.1159/000316265
更新日期:2010-01-01 00:00:00
abstract::Fetal weight prediction with ultrasonic measurements of biparietal diameter (BPD) and abdominal circumference (AC) using the equation by Shepard et al. [1982] was tested prospectively in 310 fetuses. Fetuses of all weight categories were included. The error of weight prediction was in the range of +684 to -880 g. One ...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000298895
更新日期:1986-01-01 00:00:00
abstract::Monochorionic triplet pregnancies are very rare. Here we report 2 cases of multiple pregnancies with monochorionic triplets following intracytoplasmic sperm injection (ICSI) and day 3 embryo transfer. The 2 women concomitantly underwent controlled ovarian hyperstimulation due to male factor infertility. Following oocy...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000076786
更新日期:2004-01-01 00:00:00
abstract::Preeclampsia has been linked to increased risk for cardiovascular disease and, more recently, to reduced risk for breast cancer later in life. The altered chronic disease risk associated with prior preeclampsia may reflect underlying metabolic differences. In this case-control study, we examined the metabolic profiles...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000084146
更新日期:2005-01-01 00:00:00
abstract::Therapeutic abortion by vacuum aspiration in the first trimester was carried out on 129 healthy multigravid women. The loss of haemoglobin at operation was estimated and the volume of blood calculated. The figures were compared to those in a group of primigravid women earlier reported. Blood loss increases with gestat...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000300997
更新日期:1978-01-01 00:00:00
abstract::Hyaluronan (HA), a high molecular weight polysaccharide, is a major component of connective tissue and is thus present in the extracellular matrix of most tissues. Increased serum concentrations have been reported in association with pre-eclampsia and liver malfunction, amongst other disorders. We have performed histo...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000052986
更新日期:2001-01-01 00:00:00
abstract::The relative roles of the cyclic nucleotide messengers cAMP and cGMP in the suppression of follicle-stimulating hormone (FSH) secretion in response to inhibin (IBN) were assessed employing rat gonadotropes in monolayer culture. While exposure of cells to gonadotropin-releasing hormone (GnRH) induced a significant incr...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000298808
更新日期:1987-01-01 00:00:00
abstract::The level of human fibronectin receptor (FNR) in plasma was measured by enzyme-linked immunosorbent assay in samples from normal pregnant women in the 1st trimester (n = 5), 2nd trimester (n = 7), 3rd trimester (n = 23), normal postpartum women day 1 (n = 4), day 2 (n = 5), day 3 (n = 8), nonpregnant women (n = 18), 2...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000294869
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:Preeclampsia (PE) is associated with oxidative stress in the maternal circulation and placenta. This study aimed to determine if inhibition of lectin-like oxidized low-density lipoprotein receptor 1 (LOX-1) gives protection against oxidative stress-mediated trophoblast dysfunction. METHODS:Plasma and placen...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000370195
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Epithelial ovarian carcinoma produces steroid hormones that may be of prognostic importance. The steroids are mainly bound to plasma albumin and sex hormone-binding globulin. Alterations in plasma protein levels influence hormonal effects. As plasma prealbumin may reflect changes in the patient's clinical st...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000292542
更新日期:1994-01-01 00:00:00
abstract::Placental proteins such as human chorionic gonadotrophin (hCG), Schwangerschaftsprotein 1 (SP1) and pregnancy-associated plasma protein A (PAPP-A) are found in the blood of pregnant women and in subjects suffering from cancer. They can also be found in the blood of healthy non-pregnant women and in the seminal fluid o...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000298985
更新日期:1985-01-01 00:00:00
abstract:BACKGROUND:Little is known about proper interval periods between the flushings of totally implantable access ports after completion of chemotherapy. Manufacturer guidelines recommend flushing catheters every 4 weeks. METHODS:This retrospective study examined whether flushing less than every 4 weeks conferred any benef...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000294919
更新日期:2010-01-01 00:00:00
abstract::The present study was undertaken to investigate the opinions of health professionals working in family planning clinics in Italy and Sweden. The comparison of two such different countries seemed of interest both to describe differences and/or similarities between the samples as well as to analyze factors that could in...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000293118
更新日期:1991-01-01 00:00:00
abstract::Adenoma malignum (minimum deviation adenocarcinoma) is a rare neoplasma of the uterine cervix, the diagnosis of wich cannot be determined by cervical smear. Recently, magnetic resonance imaging (MRI) was reported as useful for its diagnosis, but differentiation of adenoma malignum from deep-seated nabothian cysts rema...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000009959
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:To assess the presence of human papillomavirus (HPV) DNA in vulvar papillomatosis, since some women with this complaint have symptoms associated with HPV infection, such as itching, burning, and dyspareunia. GOAL:To reassure the patients that they do not have a transmissible viral disease, by...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000292350
更新日期:1995-01-01 00:00:00
abstract:BACKGROUND/AIMS:Dyslipidemia is common in women with polycystic ovary syndrome (PCOS) irrespective of age. Our aim was to investigate soluble tumor necrosis factor like weak inducer of apoptosis (sTWEAK), a cardiovascular risk marker in PCOS, and to determine if it is associated with dyslipidemia in youth. METHODS:A p...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000447590
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVE:To perform a health economics analysis of 5 screening programs for osteoporosis in perimenopausal Thai women comparing two alternatives; without intervention and universal treatment without screening. DESIGN:A decision analysis was performed to evaluate five screening strategies: Dual energy X-ray absorptiom...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000092803
更新日期:2006-01-01 00:00:00
abstract::This is a descriptive and cross-sectional study aiming to determine the factors affecting sexual life in pregnant women. The study was carried out in 238 women in Malatya, Turkey. It was found that 61.4% regarded coitus as a risk during pregnancy, 31.9% did not have any knowledge about this matter. In 81.5% sexual lif...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000075582
更新日期:2004-01-01 00:00:00
abstract::Oviducts of 35 mature, white New Zealand rabbits were injured by a laser beam, using various powers from 25 to 40 W, and by a series of pulses of 1/10, 1/20 or 1/100 s duration. The contralateral oviducts served as controls and were injured at similar areas by a scalpel. The injured areas of both tubes were histologic...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000299610
更新日期:1981-01-01 00:00:00