Usefulness of bezafibrate for ovulation induction in clomiphene citrate-resistant polycystic ovary syndrome patients with dyslipidemia: a prospective pilot study of seven cases.

Abstract:

BACKGROUND:Dyslipidemia is commonly observed in polycystic ovary syndrome (PCOS) patients. Bezafibrate is a drug for dyslipidemia acting through peroxisome proliferator-activated receptors. We investigated the effects of bezafibrate for ovulation induction in patients with PCOS with dyslipidemia who were resistant to clomiphene citrate (CC). METHODS:This was a prospective pilot study. Seven infertile, CC-resistant, PCOS patients with dyslipidemia were enrolled in this study. The participants received bezafibrate at 400 mg/day from day 1 of menses and CC at 100 mg/day from day 5 of menses simultaneously until one follicle measuring at least 18 mm in diameter was found by transvaginal ultrasound. The main outcome was ovulation rate. RESULTS:Five of 7 patients successfully ovulated. The mean number of days of menses until the follicle reached 18 mm in diameter was 16 ± 3 (range 13-20). Monofollicular development was observed in all patients that ovulated. One woman became pregnant and delivered a healthy baby. CONCLUSION:Bezafibrate may be effective for ovulation induction in CC-resistant PCOS patients with dyslipidemia.

journal_name

Gynecol Obstet Invest

authors

Hara S,Takahashi T,Amita M,Igarashi H,Kurachi H

doi

10.1159/000316265

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

166-72

issue

3

eissn

0378-7346

issn

1423-002X

pii

000316265

journal_volume

70

pub_type

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