Abstract:
BACKGROUND/AIMS:To determine whether genetic alterations in the CD9 gene are associated with female infertility in humans. METHODS:We sequenced the entire coding region of this gene in 86 Japanese women with unexplained infertility and further conducted a case-control study of six tagging single nucleotide polymorphisms (SNPs) in this gene using an additional 164 samples obtained from a fertile control group. RESULTS:No disease-causing mutation in the CD9 gene was evident in these samples and no significant association between the tagging SNPs and the studied cohort was identified. CONCLUSIONS:Our findings do not support the hypothesis that genetic alterations of the CD9 gene cause female infertility in humans.
journal_name
Gynecol Obstet Investjournal_title
Gynecologic and obstetric investigationauthors
Nishiyama S,Kishi T,Kato T,Suzuki M,Nishizawa H,Pryor-Koishi K,Sawada T,Nishiyama Y,Iwata N,Udagawa Y,Kurahashi Hdoi
10.1159/000262451subject
Has Abstractpub_date
2010-01-01 00:00:00pages
116-21issue
2eissn
0378-7346issn
1423-002Xpii
000262451journal_volume
69pub_type
杂志文章abstract::In the present study we have measured the concentrations of interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) in preovulatory follicular fluid (FF) samples obtained from patients undergoing ovulation induction with human menopausal gonadotropin/human chorionic gonadotropin. In 13 of the 24 (54...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000294853
更新日期:1992-01-01 00:00:00
abstract::The relationship between contraction changes and cAMP production under long-term application of ritodrine was investigated using longitudinal muscle strips of pregnant (Day 21) rat uterus. Cellular cAMP gradually increased up to 20 min, then decreased to the control level and fluctuated after 90 min in the presence of...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000293119
更新日期:1991-01-01 00:00:00
abstract:OBJECTIVE:Human placentae from normal and pre-eclamptic pregnancies were evaluated for possible changes in gene expression by microarray analysis to uncover new clues for the research of the etiology of pre-eclampsia. METHODS:Placentae from five normal pregnancies and five pregnancies complicated by pre-eclampsia were...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000092857
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:Genetic factors may play a role in male infertility. METHODS:In a prospective case-control study, we assessed the allele and genotype frequencies of the TNFalpha -308 C-->T and -863 C-->A polymorphisms, detected by PCR of sperm DNA, of 577 Caucasian men recruited in an infertility clinic. Semen sampling was...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000126494
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVES:To investigate the signs, symptoms and changes in the vaginal milieu that could be associated with cervical human papillomavirus infection (CHPI). STUDY DESIGN:Women (n = 972) attending for contraceptive advice were tested for human papillomavirus in cervical samples. Results of gynecological history, exami...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000291818
更新日期:1997-01-01 00:00:00
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journal_title:Gynecologic and obstetric investigation
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doi:10.1159/000009933
更新日期:1998-01-01 00:00:00
abstract::Serum calcium, inorganic phosphate and heat-labile alkaline phosphatase (HLAP) have been estimated in maternal and cord sera of 120 pregnant women at labour. 75 women who did not take any vitamin D supplements during pregnancy showed statistically significant hypocalcaemia, hypophosphataemia and elevation of HLAP. Hyp...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000299597
更新日期:1981-01-01 00:00:00
abstract:OBJECTIVE:To determine whether a diminished intrapartum amniotic fluid volume represents a risk of adverse neonatal outcome when it occurs in conjunction with prolonged labor. METHODS:The intrapartum amniotic fluid index (iAFI) was measured in 242 parturients over 35 weeks of gestation during 1st-stage labor, and the ...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000049402
更新日期:2002-01-01 00:00:00
abstract:AIMS:To determine the cut-off level of endometrial thickness for detecting endometrial disease on a large scale of screening and to examine the usefulness of transvaginal ultrasonography (TVS) for endometrial disease screening in asymptomatic postmenopausal Japanese women. METHODS:The study involved 1,400 postmenopaus...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000087375
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journal_title:Gynecologic and obstetric investigation
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更新日期:2002-01-01 00:00:00
abstract::Advances in fetal echocardiography enable the prenatal diagnosis of a vast majority of congenital heart defects. On the other hand, ostium secundum atrial septal defect is difficult to diagnose in the fetus. Although a defect of minor clinical significance, this may be the only intrauterine finding of a chromosomal an...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000009910
更新日期:1998-01-01 00:00:00
abstract::The rate of spontaneous and methotrexate (MTX)-induced chromosome breakage was studied in individuals with a history of habitual abortions in whom a structural chromosomal aberration was found in a single cell during routine cytogenetic analysis. Twelve such individuals were selected because they were not under the in...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000292599
更新日期:1993-01-01 00:00:00
abstract::Adenocarcinoma of the endometrium with intrauterine pregnancy is extremely rare. We report the case of a 35-year-old woman with endometrial cancer discovered in the 7th gestational week. A therapeutic abortion was performed and because of bleeding and spotting dilatation and curettage was done 10 days later. Histology...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000292043
更新日期:1996-01-01 00:00:00
abstract::The identification of immunoreactive beta-endorphin, beta-lipotropin and ACTH from extracts of human placentas by radioimmunoassay suggests a probable synthesis of these peptides in the placenta. In this study we investigated the presence of beta-endorphin and ACTH in placenta, amniotic membranes and umbilical cord us...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000299023
更新日期:1985-01-01 00:00:00
abstract::Our objective was to compare ophthalmic artery pulsatility index values from normal pregnant women with those from preeclampsia patients. The ophthalmic artery of 20 normotensive pregnant women, 7 mildly preeclamptic and 2 severely preeclamptic patients was studied once with color Doppler flow imaging and pulsed Doppl...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000292298
更新日期:1995-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1159/000092375
更新日期:2006-01-01 00:00:00
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journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000009919
更新日期:1998-01-01 00:00:00
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journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000299913
更新日期:1979-01-01 00:00:00
abstract::We have previously shown a marked diurnal variation in the excretion of cortisol and 6 beta-hydroxycortisol at 36-38 weeks pregnancy with no variation in estrogen excretion. Since others have shown a reciprocal relationship between plasma levels of estriol and cortisol at 30-35 weeks of pregnancy, we decided to determ...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000298855
更新日期:1987-01-01 00:00:00
abstract:BACKGROUND/AIMS:To evaluate patient satisfaction after laparoscopic supracervical (LASH) or total hysterectomy (TLH). METHODS:Retrospective study of patient satisfaction after LASH or TLH. RESULTS:We studied 40 cases of LASH and another 40 of TLH. The age of the patients, marital status, education level and employmen...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000184679
更新日期:2009-01-01 00:00:00
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journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000292438
更新日期:1994-01-01 00:00:00
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journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000293682
更新日期:1988-01-01 00:00:00
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journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000443829
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:The aim of the present study was to evaluate the dynamic changes in serially obtained amniotic fluid index values and to determine any association with intrapartum fetal distress in a term population. MATERIALS AND METHODS:All patients, > or = 40 weeks of gestational age, evaluated at the Institute of Obstet...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000291535
更新日期:1997-01-01 00:00:00
abstract::The aim of this study was to present our preliminary data about nasal bone measurements at 11-14 weeks of pregnancy. This study was conducted in our prenatal unit between 2000 and 2003. A total of 642 pregnant women (single pregnancies) were enrolled into the study. During the first trimester of pregnancy, crown-rump ...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000078499
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND/AIMS:To compare the efficacy and safety of trocar-site infiltration with lidocaine and no intervention for postoperative pain relief after diagnostic laparoscopy. METHODS:A randomized clinical trial of women with infertility scheduled for diagnostic laparoscopy without additional procedures in Life Institut...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章,随机对照试验
doi:10.1159/000490565
更新日期:2019-01-01 00:00:00
abstract::The scanning electron microscopy by virtue of its high resolution topographic reproduction of epithelial surfaces lining the female genital tract, provides unique information toward understanding the anatomy and physiology of the female reproductive system. The human Fallopian ectopic pregnancy is an urgent gynecologi...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000299226
更新日期:1983-01-01 00:00:00
abstract:AIMS:The purpose was to investigate the influence of delivery mode on the postpartum regression of abnormal cervical cytology. METHODS:A retrospective review was conducted of 64 pregnant women with abnormal cervical cytology at Yonsei University Health System in Korea between 2001 and 2008. A Papanicolaou smear and pa...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000324500
更新日期:2011-01-01 00:00:00
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journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000292284
更新日期:1996-01-01 00:00:00
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journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000292618
更新日期:1993-01-01 00:00:00