CD9 gene variations are not associated with female infertility in humans.

Abstract:

BACKGROUND/AIMS:To determine whether genetic alterations in the CD9 gene are associated with female infertility in humans. METHODS:We sequenced the entire coding region of this gene in 86 Japanese women with unexplained infertility and further conducted a case-control study of six tagging single nucleotide polymorphisms (SNPs) in this gene using an additional 164 samples obtained from a fertile control group. RESULTS:No disease-causing mutation in the CD9 gene was evident in these samples and no significant association between the tagging SNPs and the studied cohort was identified. CONCLUSIONS:Our findings do not support the hypothesis that genetic alterations of the CD9 gene cause female infertility in humans.

journal_name

Gynecol Obstet Invest

authors

Nishiyama S,Kishi T,Kato T,Suzuki M,Nishizawa H,Pryor-Koishi K,Sawada T,Nishiyama Y,Iwata N,Udagawa Y,Kurahashi H

doi

10.1159/000262451

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

116-21

issue

2

eissn

0378-7346

issn

1423-002X

pii

000262451

journal_volume

69

pub_type

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