The plasma homocysteine levels are increased in polycystic ovary syndrome.


:Women with polycystic ovary syndrome (PCOS) have several cardiovascular disease risk factors. Since hyperhomocysteinemia is associated with early atherosclerosis, it was postulated that the homocysteine levels are higher in PCOS patients than in control subjects which, therefore, may explain the cardiovascular disease risk. Thirty-five women with PCOS and 20 healthy subjects were studied. Endocrine assays, lipid profile, homocysteine and insulin level determinations, and ultrasound evaluation were performed in all subjects. We found significantly higher mean plasma homocysteine concentrations in patients with PCOS as compared with controls (10.4 +/- 4.4 vs. 7.2 +/- 1.5 ng/dl; p < 0.003). These data show that in PCOS early atherosclerosis is not exclusively dependent on hyperinsulinemia and elevated lipid profile - PCOS patients are exposed to significantly higher homocysteine levels which might increase the cardiovascular disease risk.


Gynecol Obstet Invest


Loverro G,Lorusso F,Mei L,Depalo R,Cormio G,Selvaggi L





Has Abstract


2002-01-01 00:00:00














  • Comparison of the long-term effects of estrogen and clomiphene citrate on pituitary and uterine function in ovariectomized rats.

    abstract::The effects of estradiol-17 beta (E2) and clomiphene citrate (CC) on pituitary-uterine function in ovariectomized (OVX) rats were compared in two experiments. In experiment 1, CC completely blocked E2 stimulation of uterine weight when administered concurrently for 10 and 30 days. In experiment 2, content of total (oc...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章


    authors: Brown JL,Byrd SJ,Mitchell AS,Nelson MF,Young RL,Chakraborty PK

    更新日期:1991-01-01 00:00:00

  • Partial hydatidiform mole in the fallopian tube.

    abstract::An extremely rare case of partial hydatidiform mole located in the right Fallopian tube was diagnosed by ultrasonography and computed tomography. The lesion was excised, and the human chorionic gonadotropin (HCG) level in early morning urine fell below 1,000 IU/ml on postoperative day 11, and the serum HCG-beta level ...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章


    authors: Terada S,Suzuki N,Uchide K,Akasofu K

    更新日期:1993-01-01 00:00:00

  • Immunosuppressant material in human seminal fluid. Inhibition of blast transformation and of NK activity by seminal fluid patients of a male infertility clinic.

    abstract::Human seminal plasma from normal or patients with abnormal parameters of the ejaculates contains an inhibitory material that expresses potent in vitro inhibitory activity on PHA-M-induced blast transformation and NK activity. Using the test of inhibition of NK activity, the semen samples from individuals with higher c...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章


    authors: Marcus ZH,Lunenfeld B,Weissenberg R,Lewin LM

    更新日期:1987-01-01 00:00:00

  • Pregnancy after intraperitoneal insemination during a natural cycle.

    abstract::The success rate after intraperitoneal insemination is also imputed to superovulation protocols. We report here the first case, to our knowledge, of pregnancy following intraperitoneal insemination during a natural cycle. ...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章


    authors: Ragni G,Lombroso GC,Wyssling H,Perotti L,Cavioni C,Crosignani PG

    更新日期:1990-01-01 00:00:00

  • Advantage or disadvantage of episiotomy compared with spontaneous perineal laceration.

    abstract::In a prospective clinical investigation of 2,144 deliveries, we elucidate the indications for episiotomy and how different methods of anesthesia affect the frequency of episiotomy and the perineal problems after episiotomy compared with those after spontaneous perineal laceration. We found a significantly higher infec...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章


    authors: Larsson PG,Platz-Christensen JJ,Bergman B,Wallstersson G

    更新日期:1991-01-01 00:00:00

  • Testicular feminization syndrome in the neonate.

    abstract::If we see a young, phenotypically female patient with an XY karyotype, it is of great importance to differentiate between the testicular feminization syndrome and gonadal dysgenesis. Patients with testicular feminization will always have normal testes, which are situated either in the ovarian fossa or in the inguinal ...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章


    authors: van Zijl JA,Evers JL,Gerver WJ

    更新日期:1990-01-01 00:00:00

  • Elevated Expression of T-Cell Immunoglobulin and Mucin Domain 3 on T Cells from Peripheral Blood in Patients with Cervical Carcinoma.

    abstract:OBJECTIVE:To investigate the expression of T-cell immunoglobulin and mucin domain 3 (TIM-3) on peripheral T cells of cervical carcinoma patients. METHODS:Peripheral blood samples from 15 high-grade cervical squamous intraepithelial lesion (HSIL) patients, 24 cervical carcinoma patients, and 21 healthy controls were co...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章


    authors: Li J,Sun XF,Shen Y,Yang Q,Dai SY

    更新日期:2020-12-04 00:00:00

  • Role of Molecular Biology in Diagnosis and Characterization of Vulvo-Vaginitis in Clinical Practice.

    abstract::The diagnosis of vulvo-vaginal complaints has always been enigmatic in obstetrics and gynecology. Patients with clear, pathognomonic symptoms end up with a proper diagnosis and treatment most of the time, but unfortunately we are now living in a world where women reach out to the Internet and readily get all informati...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章


    authors: Donders GGG,Ravel J,Vitali B,Netea MG,Salumets A,Unemo M

    更新日期:2017-01-01 00:00:00

  • Plasma fibronectin receptor levels during pregnancy complicated by preeclampsia and abruptio placentae.

    abstract::The level of human fibronectin receptor (FNR) in plasma was measured by enzyme-linked immunosorbent assay in samples from normal pregnant women in the 1st trimester (n = 5), 2nd trimester (n = 7), 3rd trimester (n = 23), normal postpartum women day 1 (n = 4), day 2 (n = 5), day 3 (n = 8), nonpregnant women (n = 18), 2...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章


    authors: Kanayama N,Terao T

    更新日期:1992-01-01 00:00:00

  • Metastatic choriocarcinoma presenting in a gravid woman.

    abstract::Choriocarcinoma coexistent with an intrauterine pregnancy is rare and requires decisions affecting mother and child to treat this aggressive tumor. An instance of this situation is presented to highlight clinical circumstances that warrant departure from accepted dogma. Pathologic aspects of choriocarcinoma are also d...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章


    authors: Byrd K,Seay R,Bechert CJ,Maxwell GL,Bicher A

    更新日期:2015-01-01 00:00:00

  • Vaginal cuff closure: a comparison between the vaginal route and laparoscopic suture in patients undergoing total laparoscopic hysterectomy.

    abstract:BACKGROUND:To compare the vaginal route and laparoscopic suture for vaginal cuff closure (VCC) in patients undergoing a total laparoscopic hysterectomy (TLH). METHODS:A total of 471 women who required hysterectomy were allocated to two groups. 261 women had TLH via VCC by the vaginal route and 210 women had TLH via VC...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章


    authors: Hwang JH,Lee JK,Lee NW,Lee KW

    更新日期:2011-01-01 00:00:00

  • Low myometrial glycogen content compared with rectus muscle in term pregnant women before labor.

    abstract::Glycogen, glucose, some nucleosides and purine base derivatives were determined in biopsies from 10 term pregnant women undergoing elective cesarean sections before labor. The concentrations were compared in the biopsies which were cut from isthmus and fundus of the uterus and m. rectus abdominis. M. rectus biopsies h...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章


    authors: Steingrímsdóttir T,Ronquist G,Ulmsten U,Waldenström A

    更新日期:1999-01-01 00:00:00

  • Primary omental pregnancy presenting with hemorrhagic shock. A case report.

    abstract::Abdominal pregnancy is a very rare and serious type of extrauterine gestation that accounts for approximately 0.003% of all ectopic pregnancies. Omental pregnancy, an extremely rare form of abdominal pregnancy, can be primary or secondary to a tubal pregnancy that aborts out of the fimbria and reimplants in the perito...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章


    authors: Ozdemir I,Demirci F,Yucel O,Alper M

    更新日期:2003-01-01 00:00:00

  • Prenatal diagnosis of minute supernumerary marker chromosomes.

    abstract::The identification of supernumerary marker chromosomes (SMC) at prenatal diagnosis is problematic, particularly for the prediction of phenotype. The assessment of phenotypic risk is based on the size, morphology and origin of the SMC. Fluorescence in situ hybridization (FISH) characterization and family studies are al...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章


    authors: Cotter PD,Drexler K,Corley AL,Covert SM,Moland JS,Govberg IJ,Norton ME

    更新日期:2005-01-01 00:00:00

  • Prolonged postpartum urinary retention: the importance of asking the right questions at the right time.

    abstract::The pathophysiology of postpartum urinary retention (PUR) is still unclear. The prevalence rate varies with the definition used and the literature discusses various risk factors. Bladder catheterization is the treatment of choice, but the best way to do it is not ascertained. Long-term sequelae seem to be rare. There ...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章


    authors: Humburg J,Holzgreve W,Hoesli I

    更新日期:2007-01-01 00:00:00

  • Pregnant women after physical and sexual abuse in Germany.

    abstract:BACKGROUND/AIMS:The aim of our study was to evaluate the prevalence of abuse among pregnant women in Germany attending our antenatal outpatient clinic and to observe whether a history of abuse had consequences for women's feelings about their pregnancy. METHODS:455 women between the 35th and 42nd weeks of gestational ...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章


    authors: Jundt K,Haertl K,Knobbe A,Kaestner R,Friese K,Peschers UM

    更新日期:2009-01-01 00:00:00

  • Combined pregnancy and starvation effects on rat tissue iron, zinc and copper contents.

    abstract::The essential metal copper, zinc and iron content in starved virgin and pregnant rat tissue has been studied. The copper content of the whole rat, which was actually increased in pregnant rats, decreased in starved pregnant rats. The differences were significant in 19-day pregnant rats. The total copper content of the...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章


    authors: Romeu A,Arola L

    更新日期:1988-01-01 00:00:00

  • Prostacyclin does not influence placental blood pool in vivo.

    abstract::In 20 healthy pregnant women placental blood pool was estimated by means of placental scintigrams before, during and after infusion of either prostacyclin (PGI2) or placebo for 10 min to study the effect of PGI2 on the local regulation of uterine blood flow. There was no difference in the mean number of counts between...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 临床试验,杂志文章


    authors: Husslein P,Gitsch E,Pateisky N,Philipp K,Leodolter S,Sinzinger H

    更新日期:1985-01-01 00:00:00

  • Imbalance between lipid peroxidation and antioxidant status in preeclampsia.

    abstract::Lipid peroxidation and the antioxidant system were investigated in the plasma and placenta of normal and preeclamptic pregnant women. A significant increase in thiobarbituric acid reactive substance (TBARS), significant decreases in total thiol (t-SH) content and superoxide dismutase (SOD) activity, and unchanged vita...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章


    authors: Mutlu-Türkoglu U,Ademoglu E,Ibrahimoglu L,Aykaç-Toker G,Uysal M

    更新日期:1998-01-01 00:00:00

  • Angiogenesis in endometriosis and angiogenic factors.

    abstract::Among angiogenic factors, VEGF secreted from activated macrophages under the influence of ovarian steroids, IL-8 expressed in endometrial stromal cells, and basic FGF expressed in endometriotic tissue and PD-ECGF expressed in lining epithelial cells independently of the sex steroidal milieu might contribute to the cha...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章,评审


    authors: Fujimoto J,Sakaguchi H,Hirose R,Wen H,Tamaya T

    更新日期:1999-01-01 00:00:00

  • Three-dimensional sonographic features of Hydrops fetalis.

    abstract:OBJECTIVE:To describe three-dimensional (3-D) sonographic features of hydrops fetalis. METHODS:A total of 6 cases with hydrops fetalis from 15 to 32 weeks of gestation were studied with transabdominal 3-D sonography (3.5 MHz). RESULTS:Before around 20 weeks of gestation, the skin becomes a transparent-like structure,...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章


    authors: Hata T,Yanagihara T,Matsumoto M,Hanaoka U,Maesato T,Tanaka Y,Kuno A,Akiyama M,Yamashiro C,Ohnishi Y,Tanaka H,Hayashi K,Yamada Y

    更新日期:1999-01-01 00:00:00

  • Two Cases of True Uterine Artery Aneurysms Diagnosed during Pregnancy.

    abstract::We report 2 cases of true uterine artery aneurysms diagnosed during pregnancy. Both cases presented with nonspecific symptoms such as urethral obstruction, minimal vaginal bleeding and lower abdominal pain in the 2nd trimester. Both aneurysms were diagnosed by color Doppler ultrasound. In the first case labor was indu...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章


    authors: Schlütter JM,Johansen G,Helmig RB,Petersen OB

    更新日期:2017-01-01 00:00:00

  • Is the incidence of urinary bladder endometriosis increasing? Figures from Finland.

    abstract:OBJECTIVE:Urinary bladder endometriosis is a severe form of endometriosis often requiring surgery. The several cases treated at our hospital in recent years has led us to evaluate the incidence of urinary bladder endometriosis in Finland. METHODS:We performed a register-based analysis of incidence of urinary bladder e...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章


    authors: Vaarala MH,Hellstrom P,Santala M

    更新日期:2010-01-01 00:00:00

  • Body mass index and severe postpartum hemorrhage.

    abstract:BACKGROUND/AIMS:The purpose of this study was to determine the relationship between maternal characteristics and severe postpartum hemorrhage (PPH). METHODS:Medical records of women who delivered at Duke University Hospital between 2001 and 2004 with an ICD-9 code for PPH were reviewed. Women with PPH who received blo...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章


    authors: Paglia MJ,Grotegut CA,Johnson LN,Thames B,James AH

    更新日期:2012-01-01 00:00:00

  • Cyclic nucleotides and suppression of follicle-stimulating hormone release by inhibin.

    abstract::The relative roles of the cyclic nucleotide messengers cAMP and cGMP in the suppression of follicle-stimulating hormone (FSH) secretion in response to inhibin (IBN) were assessed employing rat gonadotropes in monolayer culture. While exposure of cells to gonadotropin-releasing hormone (GnRH) induced a significant incr...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章


    authors: Simpson WG,Vernon MW,Maley BE,Rush ME

    更新日期:1987-01-01 00:00:00

  • Acute effect of dihydralazine on uteroplacental blood flow in hypertension during pregnancy.

    abstract::The uteroplacental blood flow was measured in 12 women with hypertension during pregnancy before and after intravenous injection of dihydralazine. After intravenous administration of 18.5 MBq (0.5 mCi) 113mIn, the gamma radiation emanating from the placenta was recorded with a computer-linked gamma camera during 10-se...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章


    authors: Lunell NO,Lewander R,Nylund L,Sarby B,Thornström S

    更新日期:1983-01-01 00:00:00

  • Diagnostic Relevance of Ferrokinetic Laboratory Markers in Anemic Pregnant Women.

    abstract:OBJECTIVES:Different forms of anemia are considered as the most frequent complication of the gestational period. By its etiology, pathogenesis, and clinical hematology, it is not a single disease. Among all forms of anemia occurring during pregnancy, iron deficiency anemia (IDA) is the most common, accounting for 80-95...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章


    authors: Aringazina R,Zharmakhanova G,Kurmanalina G,Bekkuzhin A,Kurmanalin B

    更新日期:2020-01-01 00:00:00

  • The stromal architecture of the immature intermediate villus of the human placenta. Functional and clinical implications.

    abstract::Scanning electron microscopy of cryofractured immature intermediate villi showed numerous intercommunicating channels in the central region of the stroma, oriented mostly parallel to the major axis of the villus. In the stromal channels, numerous Hofbauer cells were present and their aspect and position inside the cha...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章


    authors: Castellucci M,Schweikhart G,Kaufmann P,Zaccheo D

    更新日期:1984-01-01 00:00:00

  • Use of cefuroxime in preventing postcesarean infection in high-risk patients.

    abstract::Prophylactic antibiotic therapy is accepted for prevention of postceasarean infection in certain risk groups. Of the antibiotic regimens presented none appears superior. Patients having a cesarean section (CS) more than 6 h after membrane rupture were given three doses of cefuroxime (1.5 g every 8th hour) in a prospec...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章


    authors: Moberg PJ,Schedvins K

    更新日期:1989-01-01 00:00:00

  • Can Genomic Amplification of Human Telomerase Gene and C-MYC in Liquid-Based Cytological Specimens Be Used as a Method for Opportunistic Cervical Cancer Screening?

    abstract:OBJECTIVE:To evaluate the effectiveness of five methods including the ThinPrep cytological test (TCT), liquid-based cytology, the human papillomavirus (HPV) test, detection of the TERC and C-MYC genes and visual inspection with acetic acid/Lugol's iodine (VIA/VILI) for opportunistic cervical cancer screening, and to ex...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章


    authors: Gao K,Eurasian M,Zhang J,Wei Y,Zheng Q,Ye H,Li L

    更新日期:2015-01-01 00:00:00