The plasma homocysteine levels are increased in polycystic ovary syndrome.

Abstract:

:Women with polycystic ovary syndrome (PCOS) have several cardiovascular disease risk factors. Since hyperhomocysteinemia is associated with early atherosclerosis, it was postulated that the homocysteine levels are higher in PCOS patients than in control subjects which, therefore, may explain the cardiovascular disease risk. Thirty-five women with PCOS and 20 healthy subjects were studied. Endocrine assays, lipid profile, homocysteine and insulin level determinations, and ultrasound evaluation were performed in all subjects. We found significantly higher mean plasma homocysteine concentrations in patients with PCOS as compared with controls (10.4 +/- 4.4 vs. 7.2 +/- 1.5 ng/dl; p < 0.003). These data show that in PCOS early atherosclerosis is not exclusively dependent on hyperinsulinemia and elevated lipid profile - PCOS patients are exposed to significantly higher homocysteine levels which might increase the cardiovascular disease risk.

journal_name

Gynecol Obstet Invest

authors

Loverro G,Lorusso F,Mei L,Depalo R,Cormio G,Selvaggi L

doi

10.1159/000058367

keywords:

subject

Has Abstract

pub_date

2002-01-01 00:00:00

pages

157-62

issue

3

eissn

0378-7346

issn

1423-002X

pii

58367

journal_volume

53

pub_type

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