Depot medroxy progesterone acetate: a poor preparatory agent for endometrial resection.

Abstract:

OBJECTIVE:To evaluate the efficacy of depot medroxy progesterone acetate (DMPA) as a preparatory agent for endometrial resection. STUDY DESIGN:Endometrial resection was performed on 50 women for excessive uterine bleeding. The patients were randomly divided into 2 equal groups, with the first group receiving DMPA and the second group not receiving any hormonal pre-medication. The resected tissue was sent for histopathology and all the patients were followed up regularly for a maximum period of 4 years. RESULTS:DMPA was found to increase the thickness of the endometrium, making it more fluffy and oedematous. The procedure in these patients was associated with a significantly greater fluid consumption and deficit. A power analysis showed the overall power of the study to be >90%. Forty-four percent of group 1 and 64% of group 2 patients achieved amenorrhoea or spotting. Three patients in all underwent a repeat procedure, and 1 a hysterectomy, following a dissatisfactory result. However, no statistically significant difference was found in the outcomes of the 2 groups. CONCLUSION:As a preparatory agent, DMPA, seems to have no added benefit. Larger studies are required to bring out differences in outcomes, if any.

journal_name

Gynecol Obstet Invest

authors

Kriplani A,Manchanda R,Monga D,Takkar D

doi

10.1159/000052969

keywords:

subject

Has Abstract

pub_date

2001-01-01 00:00:00

pages

180-3

issue

3

eissn

0378-7346

issn

1423-002X

pii

52969

journal_volume

52

pub_type

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