Long-term effects of valproic acid on reproductive endocrine functions in Turkish women with epilepsy.

Abstract:

:The long-term effects of valproic acid (VPA) on reproductive endocrine functions in women with epilepsy (WWE) were studied. Serum reproductive hormone concentrations, clinical findings and ovarian morphology were analyzed in 71 WWE who had been receiving antiepileptic drugs (AED) for a minimum of 2 years. Of the 71 WWE, polycystic ovarian syndrome (PCOS) (p = 0.011) and menstrual irregularities (p = 0.009) were found to be more prevalent in women receiving VPA treatment when compared to women on non-VPA treatment. There was no statistically significant dose or duration-related rise of risk for patients who developed PCOS and menstrual irregularities and those who were not on long-term VPA therapy. The lack of a duration-related reproductive dysfunction in this patient population may support the hypothesis of early occurring VPA-associated metabolic and endocrine changes.

journal_name

Gynecol Obstet Invest

authors

Gorkemli H,Genc BO,Dogan EA,Genc E,Ozdemir S

doi

10.1159/000203537

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

223-7

issue

4

eissn

0378-7346

issn

1423-002X

pii

000203537

journal_volume

67

pub_type

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