Abstract:
:This prospective study was designed to determine whether there would be a higher incidence of congenital cardiovascular malformation (CCVM) in pregnant women with certain risk factors. Fetal echocardiography, from second trimester of term, was performed in 1,659 pregnant women with risk factors for CCVMs and 826 pregnant women without risk factors from March 1990 to April 1995. Two-dimensional imaging, fetal M mode measurements, Doppler waveform velocity and Doppler color flow mapping were used for fetal heart examination. During this period, 70 fetuses with major cardiovascular malformations were found. The prenatal detection rate was determined as 2.8% (70/2,485) in our study. The rate in the high-risk group, however, was 3.7% (61/1,659). Of all indications, fetal risk factors had the highest rate (9.3%, 46/494) of detected CCVMs. Maternal and familial indications could be excluded from the high-risk group as they did not show any increased incidence over the low-risk group. We suggest that fetal echocardiography is mandatory in the high-risk group, especially in cases with fetal and placental risk factors. Fetal cardiac screening in the hands of first-line sonographers has a major role in prenatal diagnosis of CCVMs in the low-risk group.
journal_name
Gynecol Obstet Investjournal_title
Gynecologic and obstetric investigationauthors
Hsieh CC,Kuo DM,Chiu TH,Hsieh TTdoi
10.1159/000291897subject
Has Abstractpub_date
1996-01-01 00:00:00pages
84-7issue
2eissn
0378-7346issn
1423-002Xjournal_volume
42pub_type
杂志文章abstract::In 8 fetal sheep under anesthesia, we examined the relationship between the fetal aorta blood flow velocity waveform and fetal mean arterial pressure after administration of norepinephrine and angiotensin II. It was hypothesized that the pulsatility index (PI) of the waveform would change during fetal hypertension. Me...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000292583
更新日期:1993-01-01 00:00:00
abstract::Prophylactic antibiotic therapy is accepted for prevention of postceasarean infection in certain risk groups. Of the antibiotic regimens presented none appears superior. Patients having a cesarean section (CS) more than 6 h after membrane rupture were given three doses of cefuroxime (1.5 g every 8th hour) in a prospec...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000293492
更新日期:1989-01-01 00:00:00
abstract::The objective of the study was to assess the effects of low-dose vaginal treatment with oestradiol before vaginal operation. In a double-blind randomized study including 43 postmenopausal women scheduled for vaginal repair operation for genital descensus, it was found that 7 patients suffered from concomitant urinary ...
journal_title:Gynecologic and obstetric investigation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000292320
更新日期:1995-01-01 00:00:00
abstract:AIM:We report a case of a mixed clear cell and endometrioid carcinoma arising in parietal endometriosis. METHODS:A 46-year-old woman presented a second recurrence of parietal endometriosis. An extensive surgical resection of the tumor was then carried out. RESULTS:Histological analysis revealed heterogeneous tissues ...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000096437
更新日期:2007-01-01 00:00:00
abstract::Women with polycystic ovary syndrome (PCOS) have several cardiovascular disease risk factors. Since hyperhomocysteinemia is associated with early atherosclerosis, it was postulated that the homocysteine levels are higher in PCOS patients than in control subjects which, therefore, may explain the cardiovascular disease...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000058367
更新日期:2002-01-01 00:00:00
abstract:OBJECTIVE:To clarify the alteration of maternal-fetal mixed lymphocyte reaction (MLR) in intrahepatic cholestasis of pregnancy (ICP). METHODS:Twenty-two patients with intrahepatic cholestasis of pregnancy and 21 normal pregnant women were recruited into the present study. Of patients with ICP, 5 also experienced pregn...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000068381
更新日期:2002-01-01 00:00:00
abstract::The objective of the present study was to compare the rate of embryo cleavage after oocyte insemination with capacitated spermatozoa in the presence or absence of follicular fluid. In the first experiment, a total of 67 oocytes were inseminated with spermatozoa which had been submitted to part of the capacitation proc...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000292545
更新日期:1994-01-01 00:00:00
abstract::ABO blood group was analyzed in 70 patients with hydatidiform mole and 53 patients with malignant trophoblastic disease. 319 healthy pregnant women served as controls. The distribution of ABO blood groups in patients with hydatidiform mole did not deviate significantly from the distribution in the controls. There was ...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000298967
更新日期:1985-01-01 00:00:00
abstract::Treatment of endometriosis with gonadotropin-releasing hormone agonists (GnRHa) is limited to 6 months because of possible adverse effects on bone metabolism. We designed a randomized, double-blind, placebo-controlled, prospective study of 27 patients with endometriosis who were given GnRHa with or without hormone add...
journal_title:Gynecologic and obstetric investigation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000010059
更新日期:1999-01-01 00:00:00
abstract::Acute intermittent porphyria is a rare autosomal dominant disease characterized by acute attacks of neuropsychiatric and neurovisceral dysfunction. In pregnancy, exacerbation of attacks in the form of seizures and acute abdomen occur due to hormonal changes. We report the case of a young woman presenting at 8 weeks of...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000091835
更新日期:2006-01-01 00:00:00
abstract::If we see a young, phenotypically female patient with an XY karyotype, it is of great importance to differentiate between the testicular feminization syndrome and gonadal dysgenesis. Patients with testicular feminization will always have normal testes, which are situated either in the ovarian fossa or in the inguinal ...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000293367
更新日期:1990-01-01 00:00:00
abstract:AIM:To compare outcomes after laparoscopic ovarian cystectomy versus fenestration/coagulation or laser ablation for the treatment of endometriomas. METHODS:Studies were identified by searching the PubMed, EMBASE, SCOPUS, and Cochrane Central Register of Controlled Trials databases using the terms ovarian, endometrioma...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章,meta分析
doi:10.1159/000351165
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:MIB 1 is a new monoclonal antibody which recognizes nuclei of proliferating cells throughout the cell cycle except during the G0 and early G1 phases. In the present study we analyzed the MIB 1 immunostaining as an index of cellular proliferation in cervical intraepithelial neoplasia (CIN) and microinvasive ca...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000291977
更新日期:1996-01-01 00:00:00
abstract:BACKGROUND:Cisplatin is used as a key drug for ovarian yolk sac tumor (YST), but relapse may occur. Details of the molecular mechanism responsible for cisplatin resistance remain unclear. METHODS:We established cisplatin-resistant ovarian YST cells (NOY1-CR) from parent NOY1. To characterize these cells, we examined c...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000320744
更新日期:2011-01-01 00:00:00
abstract::Human seminal plasma from normal or patients with abnormal parameters of the ejaculates contains an inhibitory material that expresses potent in vitro inhibitory activity on PHA-M-induced blast transformation and NK activity. Using the test of inhibition of NK activity, the semen samples from individuals with higher c...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000298834
更新日期:1987-01-01 00:00:00
abstract::The present study investigated plasma activity of 5'-nucleotidase, a key enzyme in the production of adenosine, in pre-eclampsia, and evaluated the relationship between changes in 5'-nucleotidase activity, and levels of uric acid, endproduct of the purine metabolism, and the severity of pre-eclampsia. We measured plas...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000067886
更新日期:2002-01-01 00:00:00
abstract::A total of 202 delivering mothers and their newborns were studied with the intention to follow the materno-fetal transmission of malaria. Malaria infection was encountered in 35 cases (17.3%) in which Plasmodium falciparum predominated in peripheral blood while P. malariae predominated on the placental surface. In cor...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000292675
更新日期:1993-01-01 00:00:00
abstract:INTRODUCTION:Expression of fibroblast activation protein (FAP) has been detected in activated fibroblasts participating in injury response, fibrotic and inflammatory conditions, and tumorigenesis. Human endometrium is equally characterized by rapid tissue remodeling events due to the reproductive tasks comprising the a...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000511439
更新日期:2020-01-01 00:00:00
abstract::Placental proteins such as human chorionic gonadotrophin (hCG), Schwangerschaftsprotein 1 (SP1) and pregnancy-associated plasma protein A (PAPP-A) are found in the blood of pregnant women and in subjects suffering from cancer. They can also be found in the blood of healthy non-pregnant women and in the seminal fluid o...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000298985
更新日期:1985-01-01 00:00:00
abstract::Endometriosis is a sex steroids-dependent disease. It has been postulated that certain genetic polymorphisms involved in sex steroids biosynthesis and metabolisms may be associated with increased risk of developing endometriosis. Despite a deluge of reports of positive associations of endometriosis with numerous polym...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章,meta分析,评审
doi:10.1159/000089011
更新日期:2006-01-01 00:00:00
abstract:OBJECTIVE:To evaluate alterations in maternal circulating angiogenin levels with advancing gestation and to assess the effect of labor stress on serum angiogenin levels in neonates delivered vaginally and by cesarean section. METHODS:The maternal circulating angiogenin concentrations were compared in 37 normotensive n...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000010270
更新日期:2000-01-01 00:00:00
abstract::The aim of this study was to explore the antimicrobial activity of human follicular fluid (HFF), to test the hypothesis that different strains of the same bacterial species could display different patterns of susceptibility to antimicrobial action of HFF, and to preliminarily investigate the possible mechanism of anti...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000074103
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND:Preeclampsia (PE) is associated with oxidative stress in the maternal circulation and placenta. This study aimed to determine if inhibition of lectin-like oxidized low-density lipoprotein receptor 1 (LOX-1) gives protection against oxidative stress-mediated trophoblast dysfunction. METHODS:Plasma and placen...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000370195
更新日期:2015-01-01 00:00:00
abstract:AIMS:To construct in vitro models of normal uterine arterial vascular network through vascular corrosion casting and explore their characteristics and clinical significances. METHODS:Three sets of uterus, vagina and bilateral adnexa were perfused and cast via uterine artery and ovarian artery, using 25, 20 and 15% chl...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000245941
更新日期:2010-01-01 00:00:00
abstract::To determine the placental clearance of lactate and bicarbonate in sheep, the fetal side of an isolated cotyledon and the umbilical circulation of the total placenta were artificially perfused. The release and uptake of lactate and bicarbonate by the perfusion fluid and the fetomaternal concentration differences of th...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000299913
更新日期:1979-01-01 00:00:00
abstract:OBJECTIVES:The aim of this study is to evaluate oxidative protein damage (OPD) by investigating protein carbonyl (PCO) and nitrotyrosine (NT) levels, oxidative stress by total thiol (T-SH), erythrocyte glutathione (GSH) and nitric oxide (NO) levels in women receiving hormone replacement therapy (HRT). MATERIALS AND ME...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000067718
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND/AIMS:To assess whether patients prefer surgery or a pessary as treatment for pelvic organ prolapse (POP). METHODS:A structured interview was performed among treated and untreated women with POP. We conducted fictive scenarios of potential disadvantages of surgery and pessary use. Our main outcome was the wi...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000336634
更新日期:2012-01-01 00:00:00
abstract::Changes in norepinephrine following a bimanual handgrip contraction test were used to evaluate the contribution of static physical effort exerted by the parturient on the rise in adrenergic stimulation observed during ongoing labor. Noradrenaline baseline values were 306.71 +/- (SE) 21.5 pg/ml); and after a maximal ef...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000298871
更新日期:1987-01-01 00:00:00
abstract:BACKGROUND/AIMS:To compare the efficacy and safety of trocar-site infiltration with lidocaine and no intervention for postoperative pain relief after diagnostic laparoscopy. METHODS:A randomized clinical trial of women with infertility scheduled for diagnostic laparoscopy without additional procedures in Life Institut...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章,随机对照试验
doi:10.1159/000490565
更新日期:2019-01-01 00:00:00
abstract::We present an unusual case in whom a small congenital hernia of the umbilical cord and associated patent omphalomesenteric duct were diagnosed at midtrimester ultrasonography. The diagnosis was confirmed following delivery, and neonatal corrective surgery was performed. We compare prenatal ultrasound findings of umbil...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000052895
更新日期:2001-01-01 00:00:00