Impaired mixed lymphocyte reaction in intrahepatic cholestasis of pregnancy.

Abstract:

OBJECTIVE:To clarify the alteration of maternal-fetal mixed lymphocyte reaction (MLR) in intrahepatic cholestasis of pregnancy (ICP). METHODS:Twenty-two patients with intrahepatic cholestasis of pregnancy and 21 normal pregnant women were recruited into the present study. Of patients with ICP, 5 also experienced pregnancy-induced hypertension (PIH). Maternal-fetal mixed lymphocyte reaction was conducted by using a morphologic transformation method, and the transformation rates of lymphocytes were compared either between ICP patients with and without pregnancy-induced hypertension, or between control and ICP group. RESULTS:In the ICP group, the transformation rates of lymphocytes were not significantly different between pregnancies with and without pregnancy-induced hypertension (p > 0.5). Compared with control, the transformation rate of lymphocytes in intrahepatic cholestasis of pregnancy decreased significantly (p < 0.001). CONCLUSION:Suppressed mixed lymphocyte reaction was observed in intrahepatic cholestasis of pregnancy and its mechanism behind and role in the disease need to be further explored.

journal_name

Gynecol Obstet Invest

authors

Dong M,Xie X,Wang Z,He J,Zhou J,Cheng Q

doi

10.1159/000068381

keywords:

subject

Has Abstract

pub_date

2002-01-01 00:00:00

pages

191-5

issue

4

eissn

0378-7346

issn

1423-002X

pii

68381

journal_volume

54

pub_type

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