Abstract:
:The concentration of collagen in the human uterine cervix decreases during pregnancy. This change contributes to the ripening process, which facilitates cervical dilatation during labor. It has been suggested that cervical collagen is partly degraded at term and after delivery. In order to evaluate this hypothesis we investigated the proportion of intact to degraded collagen after solubilization of about 86% of the collagen with pepsin in acetic acid. Total collagen was quantitated as hydroxyproline whereas intact collagen was estimated by SDS-gel electrophoresis. The proportion of intact collagen to total collagen did not change during pregnancy and delivery. Furthermore it was similar to that of intact standard collagen. Thus, even if the concentration of collagen is diminished during pregnancy as a result of increased collagenolytic activity, there is no indication of a qualitative change of the remaining collagen.
journal_name
Gynecol Obstet Investjournal_title
Gynecologic and obstetric investigationauthors
Uldbjerg N,Malmström A,Ekman G,Ulmsten Udoi
10.1159/000298975subject
Has Abstractpub_date
1985-01-01 00:00:00pages
68-73issue
2eissn
0378-7346issn
1423-002Xjournal_volume
20pub_type
杂志文章abstract::We report the third case of a prenatal diagnosis of Larsen's syndrome, which is the first report affecting both a 37-year-old primiparous caucasian woman and her fetus not considered to have Larsen's syndrome until the finding of bilateral clubfeet was demonstrated on screening ultrasound at 23 weeks of gestation. His...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000010050
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND/AIMS:A phase II study was conducted to assess the activity and toxicity of weekly docetaxel in patients with advanced or recurrent cancer of the cervix. METHODS:Eligible patients were required to have measurable disease with adequate performance status, bone marrow, renal and hepatic function. Patients were...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000106489
更新日期:2007-01-01 00:00:00
abstract::To determine the relationship between abnormal fetal heart rate (FHR) patterns, fetal oxygen content by reflectance pulse oximetry, and the effects of maternal oxygen administration, 158 intrapartum women consisting of 120 women with normal FHR patterns, and 38 women with varying degrees of variable FHR decelerations ...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000291404
更新日期:1997-01-01 00:00:00
abstract::Preeclampsia has been linked to increased risk for cardiovascular disease and, more recently, to reduced risk for breast cancer later in life. The altered chronic disease risk associated with prior preeclampsia may reflect underlying metabolic differences. In this case-control study, we examined the metabolic profiles...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000084146
更新日期:2005-01-01 00:00:00
abstract::A prospective randomized trial comprising 90 patients was undertaken to evaluate three different regimens of tinidazole in the treatment of anaerobic vaginosis. Each group consisted of 30 women. The three regimens were: (A) oral tinidazole (150 mg X 2) for 7 days, (B) same oral treatment as above but also the partner ...
journal_title:Gynecologic and obstetric investigation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000293524
更新日期:1989-01-01 00:00:00
abstract::An extremely rare case of partial hydatidiform mole located in the right Fallopian tube was diagnosed by ultrasonography and computed tomography. The lesion was excised, and the human chorionic gonadotropin (HCG) level in early morning urine fell below 1,000 IU/ml on postoperative day 11, and the serum HCG-beta level ...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000292708
更新日期:1993-01-01 00:00:00
abstract:AIMS:To determine the cut-off level of endometrial thickness for detecting endometrial disease on a large scale of screening and to examine the usefulness of transvaginal ultrasonography (TVS) for endometrial disease screening in asymptomatic postmenopausal Japanese women. METHODS:The study involved 1,400 postmenopaus...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000087375
更新日期:2005-01-01 00:00:00
abstract::Burch colposuspension for correction of urinary incontinence is rarely followed by complications. A very rarely described complication is ureteral kinking, which tends to occur in patients with previous pelvic surgeries. We present 6 additional cases of this rare complication and recommend appropriate intraoperative d...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000293398
更新日期:1990-01-01 00:00:00
abstract:OBJECTIVE:Human placentae from normal and pre-eclamptic pregnancies were evaluated for possible changes in gene expression by microarray analysis to uncover new clues for the research of the etiology of pre-eclampsia. METHODS:Placentae from five normal pregnancies and five pregnancies complicated by pre-eclampsia were...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000092857
更新日期:2006-01-01 00:00:00
abstract::An evaluation of the age distribution of erythrocytes in twin gestation was performed. Based on previous studies on age distribution of erythrocytes in late pregnancy, we have proposed that a more pronounced shift in age distribution of erythrocytes in twin pregnancy may be expected. We have used the density distribut...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000292618
更新日期:1993-01-01 00:00:00
abstract:AIMS:To investigate misoprostol use as a self-administered medical abortifacient and to explore the knowledge and availability of misoprostol and attitudes towards it among Saudi women. METHODS:A questionnaire-based cross-sectional study was conducted in obstetric and gynecological outpatient clinics at private and te...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000363238
更新日期:2014-01-01 00:00:00
abstract:AIM:The objective of the present study was to investigate the development of mouse embryos and the chromosomal status after the pre-implantation treatment with paclitaxel (Taxol) based on the reports that indicate Taxol improves the developmental potential of vitrified human and mouse oocytes. METHODS:Outbred female m...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000502820
更新日期:2020-01-01 00:00:00
abstract::Circulating levels of leptin, estradiol (E(2)) and progesterone (P(4)) throughout normal menstrual cycles (n = 13), and controlled, stimulated cycles (n = 33) were examined using sensitive specific radioimmunoassays in order to investigate the relationships between sex hormones (E(2), P(4)). Serum leptin levels during...
journal_title:Gynecologic and obstetric investigation
pub_type: 临床试验,杂志文章
doi:10.1159/000010228
更新日期:2000-01-01 00:00:00
abstract::To study the effect of calcium and vitamin D supplementation on the incidence of toxaemia of pregnancy, 200 randomly selected pregnant women (supplemented group), were put on calcium (375 mg/day) and vitamin D (1,200 IU/day) supplements at 20-24 weeks of pregnancy onwards. Another 200 pregnant women constituted the no...
journal_title:Gynecologic and obstetric investigation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000298772
更新日期:1987-01-01 00:00:00
abstract::We treated a patient with an ovarian tumor histologically consisting of an endometrial cyst, dermoid cyst and mucinous cystadenoma, in the same ovary. A comparative study between ultrasonic and histological findings was done. The usefulness, drawbacks and limitations in the ultrasonic evaluation of ovarian tumors are ...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000293646
更新日期:1989-01-01 00:00:00
abstract:AIM:The aim of this study was to assess various treatment options in stage IB2 cervical cancer patients. METHODS:Between January 1995 and May 2007, 63 patients with stage IB2 were treated by radical hysterectomy (n = 28), primary concurrent chemoradiation (CCRT, n = 16) or radiation therapy (RT, n = 19). Disease-free ...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000320722
更新日期:2011-01-01 00:00:00
abstract::The psychological state of 102 infertile women undergoing in vitro fertilization and embryo transfer was investigated. The levels of anxiety were measured by the state trait anxiety inventory and the manifest anxiety scale. The process of accepting infertility and attitudes toward treatment were explored by a semistru...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000291510
更新日期:1997-01-01 00:00:00
abstract::The feasibility of performing hysteroscopic endomyometrial resection using isotonic 2.2% glycine as distension medium was studied in 181 consecutive operations. A standard continuous flow loop-resectoscope was used. Distension was achieved by means of a gravity-fed system and glycine flowed out under its own pressure....
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000010119
更新日期:1999-01-01 00:00:00
abstract::This prospective study was designed to determine whether there would be a higher incidence of congenital cardiovascular malformation (CCVM) in pregnant women with certain risk factors. Fetal echocardiography, from second trimester of term, was performed in 1,659 pregnant women with risk factors for CCVMs and 826 pregn...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000291897
更新日期:1996-01-01 00:00:00
abstract:AIMS:To construct in vitro models of normal uterine arterial vascular network through vascular corrosion casting and explore their characteristics and clinical significances. METHODS:Three sets of uterus, vagina and bilateral adnexa were perfused and cast via uterine artery and ovarian artery, using 25, 20 and 15% chl...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000245941
更新日期:2010-01-01 00:00:00
abstract::Pre-implantation blastocysts or trophoblast, obtained from ectoplacental cones, were transferred to the right oviducts of both pregnant and nonpregnant mice. Blastocysts which remained within the oviductal lumen did not show evidence of further differentiation into trophoblast although they readily implanted on variou...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000299117
更新日期:1984-01-01 00:00:00
abstract::We immunohistologically studied the hepatic tissue sections in cases with the syndrome of hemolysis, elevated liver enzymes, and low platelets (HELLP syndrome; n = 2) and acute fatty liver of pregnancy (AFLP; n = 2) compared to necropsy controls. Unlike in the AFLP cases, a marked infiltration of neutrophils in liver ...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000292053
更新日期:1996-01-01 00:00:00
abstract::Thyroxine-binding globulin (TBG) and free thyroxine (FT4) were studied in 172 apparently healthy women giving birth to malformed children. The malformations were divided into two groups: minor malformations (group A) and major malformations (group B). The blood samples were usually drawn in the first trimester. Group ...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000293608
更新日期:1989-01-01 00:00:00
abstract::Amniotic fluids from women in West Virginia were evaluated for the presence of antibacterial activity by a bioassay technique. 41% of 32 third trimester samples were inhibitory. Evaluation of additional test organisms emphasized differences in susceptibility of various bacterial strains; two isolates of Escherichia co...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000299390
更新日期:1983-01-01 00:00:00
abstract::Full vaginal casts of 39 caucasian women, 13 each nulliparous, uniparous and multiparous, were made using vinyl polysiloxane impression material. Vaginal lengths were measured with polished acrylic rods inserted by the subjects, and introital diameters were measured with conical polypropylene flasks. Parallel sided, c...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000291946
更新日期:1996-01-01 00:00:00
abstract:OBJECTIVES:In this study, we aimed to compare the levels of maternal blood lipids, placental and venous blood lipid transporters, and inflammatory factor receptors in pregnant women with and without gestational diabetes mellitus (GDM). We also aimed to figure out the relationship between these values and neonatal weigh...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000510032
更新日期:2021-01-22 00:00:00
abstract:OBJECTIVE:Isotretinoin is used in acne vulgaris treatment for more than 20 years. Isotretinoin has serious side effects on many organs, but there are no comprehensive studies investigating its possible toxic effects on reproductive organs. Thus, we aimed to investigate the possible toxic effects of isotretinoin adminis...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000510031
更新日期:2020-01-01 00:00:00
abstract::Adenocarcinoma of the endometrium with intrauterine pregnancy is extremely rare. We report the case of a 35-year-old woman with endometrial cancer discovered in the 7th gestational week. A therapeutic abortion was performed and because of bleeding and spotting dilatation and curettage was done 10 days later. Histology...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000292043
更新日期:1996-01-01 00:00:00
abstract:PURPOSE:To analyze the effects and potential benefits of a single midcycle dose of follicle-stimulating hormone (FSH) prior to human chorionic gonadotropin (hCG) administration during unstimulated in vitro fertilization (IVF) cycles. METHODS:Twenty-five cycles from 20 patients receiving 150 IU of FSH 42-44 h and 10,00...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000291825
更新日期:1997-01-01 00:00:00
abstract::Ciliary neurotrophic factor (CNTF) is a gp130 neuroregulatory cytokine belonging to the interleukin-6-type cytokine superfamily. Several lines of evidence suggest that the concentrations of interleukin-6 are elevated in the peritoneal fluid of endometriosis patients. To our knowledge, no study on whether this might al...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000072694
更新日期:2003-01-01 00:00:00