Abstract:
BACKGROUND/AIMS:Low molecular weight heparin is recommended for the treatment of venous thromboembolism (VTE) during pregnancy. However, there are few reliable data regarding the safety of therapeutic doses of tinzaparin in this setting. The objective of this study was to assess the safety of once-daily therapeutic doses of tinzaparin for the treatment of VTE during pregnancy. METHODS:A retrospective study was carried out in 3 tertiary care centres in France, from 1998 to 2009, including consecutive pregnant women who received once-daily therapeutic doses of tinzaparin (175 IU/kg/day). RESULTS:We analyzed 87 pregnancies in 83 women, representing a total of 13,320 patient-days of treatment. Live-birth rate was 97.8%, with one case of miscarriage (<20 weeks of gestation) and one case of intrauterine foetal death (≥20 weeks). There was no antenatal major bleeding. Major bleeding occurred in 4 women during an emergency caesarean section. No case of heparin-induced thrombocytopenia and no maternal death were reported. There was no neonatal haemorrhage and no case of congenital abnormality. VTE recurred on treatment in one patient and after treatment interruption for several days in 2 other patients. CONCLUSIONS:These results support the safety of once-daily tinzaparin at therapeutic dose for the treatment of VTE during pregnancy.
journal_name
Gynecol Obstet Investjournal_title
Gynecologic and obstetric investigationauthors
Parent F,Deruelle P,Sanchez O,Meyer G,Girard P,Jilwan F,Boyer-Neumann C,Wolf M,Simonneau Gdoi
10.1159/000367846subject
Has Abstractpub_date
2015-01-01 00:00:00pages
256-62issue
4eissn
0378-7346issn
1423-002Xpii
000367846journal_volume
79pub_type
杂志文章abstract::As part of a case control within cohort study 472 pregnant women answered a questionnaire post partum. Serum relaxin concentrations were measured by a homologous ELISA in samples collected from the women in the 30th week of pregnancy. Serum relaxin concentrations were not associated with pregnancy-associated pelvic pa...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000292438
更新日期:1994-01-01 00:00:00
abstract::Cervico-oculo-acousticus syndrome is a very rare entity with only 21 cases described in the world literature. A study of a case of this syndrome with pregnancy is presented. This primigravida, in addition to the classical triad of the syndrome, had other dysmorphic features such as short stature (141 cm), and marked t...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000293115
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND:To compare the vaginal route and laparoscopic suture for vaginal cuff closure (VCC) in patients undergoing a total laparoscopic hysterectomy (TLH). METHODS:A total of 471 women who required hysterectomy were allocated to two groups. 261 women had TLH via VCC by the vaginal route and 210 women had TLH via VC...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000316052
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND/AIMS:To evaluate the degree of pain during and after office hysteroscopy with combined intracervical and intrauterine anesthesia compared to intracervical anesthesia only. METHODS:We evaluated the amount of pain experienced during office hysteroscopy using combined local intracervical and intrauterine anest...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000252957
更新日期:2010-01-01 00:00:00
abstract::The possible interaction of the newly developed triazole antifungal SCH 39304 with low-dose combined oral contraceptives (OCs) was studied in 15 healthy women. Serum levels of ovarian and adrenocortical steroids and sex hormone-binding globulin (SHBG) were analyzed in samples collected during the OC cycles immediately...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000293003
更新日期:1991-01-01 00:00:00
abstract::The mechanisms by which anti-phospholipid antibodies (aPLs) may induce pregnancy losses, intrauterine growth retardation and pregnancy-induced hypertension are not clearly understood. Moreover, there is a controversy regarding the possible direct effects of these antibodies on the physiology of the placenta since the ...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND:We sought to compare the pullout strengths of the sacral end of the sacrocolpopexy mesh when attached using one suture at the first versus second sacral vertebral level (S1 vs. S2) in female cadaveric pelvises. METHODS:The sacral vertebrae were isolated in 9 unembalmed female cadavers, and segments of polyp...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000338892
更新日期:2012-01-01 00:00:00
abstract::Immunocytochemical study in paraffin sections of human endometrium showed that the receptor contents for both oestrogen and progesterone receptors were lower than in the frozen sections although the staining patterns were similar in these two section types. Pretreating the specimens with proteolytic enzymes like tryps...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000292422
更新日期:1995-01-01 00:00:00
abstract::Serum samples were collected from 199 patients attending a gynaecological clinic, colposcopy specimens being taken at the same time for routine pathology of paraffin sections which ranged from normal, through the degrees of dysplasia to carcinoma in situ. Other parameters noted were age, number of pregnancies and time...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000299470
更新日期:1982-01-01 00:00:00
abstract:INTRODUCTION:Expression of fibroblast activation protein (FAP) has been detected in activated fibroblasts participating in injury response, fibrotic and inflammatory conditions, and tumorigenesis. Human endometrium is equally characterized by rapid tissue remodeling events due to the reproductive tasks comprising the a...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000511439
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVES:In this study, we aimed to compare the levels of maternal blood lipids, placental and venous blood lipid transporters, and inflammatory factor receptors in pregnant women with and without gestational diabetes mellitus (GDM). We also aimed to figure out the relationship between these values and neonatal weigh...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000510032
更新日期:2021-01-22 00:00:00
abstract::We report a postmenopausal patient with serous papillary cystadenocarcinoma of the ovary associated with large abscess formation and estrogen production. Ovarian cancer accompanied by stromal function is an occasional event, but large abscess association is a rarity. The present case is thus even rarer. Her clinical c...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000292710
更新日期:1993-01-01 00:00:00
abstract:OBJECTIVE:MIB 1 is a new monoclonal antibody which recognizes nuclei of proliferating cells throughout the cell cycle except during the G0 and early G1 phases. In the present study we analyzed the MIB 1 immunostaining as an index of cellular proliferation in cervical intraepithelial neoplasia (CIN) and microinvasive ca...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000291977
更新日期:1996-01-01 00:00:00
abstract:BACKGROUND/AIM:Marginal or decreased amniotic fluid volume by ultrasound estimate and fetal growth restriction have been shown to be significantly associated with perinatal mortality. The association of fetal growth restriction and precisely measured amniotic fluid volume is unknown. The purpose of this study was to de...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000324570
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVE:The aim of the present study was to evaluate the dynamic changes in serially obtained amniotic fluid index values and to determine any association with intrapartum fetal distress in a term population. MATERIALS AND METHODS:All patients, > or = 40 weeks of gestational age, evaluated at the Institute of Obstet...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000291535
更新日期:1997-01-01 00:00:00
abstract::During a 9-year period 61 Israeli Jewish Patients with histologically confirmed invasive squamous cell carcinoma of the uterine cervix (SUC) were treated by irradiation alone. A large proportion of the patients (44.2%) were more than 60 years old and only 27.9% were diagnosed as having stage IB disease. This is attrib...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000299404
更新日期:1983-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the effectiveness of five methods including the ThinPrep cytological test (TCT), liquid-based cytology, the human papillomavirus (HPV) test, detection of the TERC and C-MYC genes and visual inspection with acetic acid/Lugol's iodine (VIA/VILI) for opportunistic cervical cancer screening, and to ex...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000371760
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:Our objective was to evaluate the direct effect of tamoxifen citrate (TAM) on the endometrium, liver, breast tissue and the lipid profile in oophorectomized (OX) rats. STUDY DESIGN:An experimental animal study. MATERIAL AND METHODS:Forty-one mature rats (33 OX) were randomly divided into four groups and rec...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000009933
更新日期:1998-01-01 00:00:00
abstract::The aim of the present experiments was to investigate a possible correlation between the occurrence of preeclampsia and the levels of norepinephrine in human myometrial biopsies obtained from the lower uterine segment at the time of cesarean section. Norepinephrine was measured directly by the technique of muscle CATS...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000293271
更新日期:1990-01-01 00:00:00
abstract::Holtzman, female rats with a plastic or copper IUD were maintained on either a dexamethasone solution (9.4 or 28 micrograms/rat/day) in the drinking water or on water alone. Animals were caged with males of proven fertility and subsequently killed at day 14 of pregnancy and the number of implantation sites counted. Bo...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000299826
更新日期:1980-01-01 00:00:00
abstract::Osteoporosis of the hip is a rare complication of pregnancy, the diagnosis of which can only be determined by radiologic means. Differentiation between osteonecrosis and osteoporosis remains problematic in some cases. Magnetic resonance imaging was reported as useful for the diagnosis of osteoporosis. Treatment of ost...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000052910
更新日期:2001-01-01 00:00:00
abstract::To study the effect of calcium and vitamin D supplementation on the incidence of toxaemia of pregnancy, 200 randomly selected pregnant women (supplemented group), were put on calcium (375 mg/day) and vitamin D (1,200 IU/day) supplements at 20-24 weeks of pregnancy onwards. Another 200 pregnant women constituted the no...
journal_title:Gynecologic and obstetric investigation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000298772
更新日期:1987-01-01 00:00:00
abstract::17 beta-Estradiol (E2), basal body temperature (BBT) and luteinizing hormone (LH), were measured in normally menstruating women. The preovulatory E2 observations were characterized by variations about a constant level during the preovula-peak. The BBT observations typically varied about a constant level during the pre...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000299523
更新日期:1982-01-01 00:00:00
abstract::Concentrations of leukotriene B4 (LTB4) and prostaglandin E2 (PGE2) in peritoneal fluid were measured in 19 women with suspected acute pelvic inflammatory disease. Acute salpingitis was verified by laparoscopy in 16 cases; 11 of them had isolation of microbes from the peritoneal cavity. Means (+/- SD) levels of perito...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000293338
更新日期:1990-01-01 00:00:00
abstract::The objective of the study was to assess the effects of low-dose vaginal treatment with oestradiol before vaginal operation. In a double-blind randomized study including 43 postmenopausal women scheduled for vaginal repair operation for genital descensus, it was found that 7 patients suffered from concomitant urinary ...
journal_title:Gynecologic and obstetric investigation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000292320
更新日期:1995-01-01 00:00:00
abstract::Ciliary neurotrophic factor (CNTF) is a gp130 neuroregulatory cytokine belonging to the interleukin-6-type cytokine superfamily. Several lines of evidence suggest that the concentrations of interleukin-6 are elevated in the peritoneal fluid of endometriosis patients. To our knowledge, no study on whether this might al...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000072694
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND:Clarifying the normal distribution of activation antigens will contribute to database construction studies of monoclonal-antibody-based therapies in endometrial disorders. METHODS:In this study, endometrial tissue samples obtained during proliferative and secretory phases and decidual samples of early pregn...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000092375
更新日期:2006-01-01 00:00:00
abstract::The crisis frequency of stress incontinence (SI) is known to be high among pregnant women. This preliminary study was performed to determine whether the diagnostic standard of the Q-tip test used in the diagnosis of SI in nonpregnant women is applicable to pregnant women. The Q-tip tests were performed regularly durin...
journal_title:Gynecologic and obstetric investigation
pub_type: 临床试验,杂志文章
doi:10.1159/000052900
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND/AIMS:A phase II study was conducted to assess the activity and toxicity of weekly docetaxel in patients with advanced or recurrent cancer of the cervix. METHODS:Eligible patients were required to have measurable disease with adequate performance status, bone marrow, renal and hepatic function. Patients were...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000106489
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Dyslipidemia is commonly observed in polycystic ovary syndrome (PCOS) patients. Bezafibrate is a drug for dyslipidemia acting through peroxisome proliferator-activated receptors. We investigated the effects of bezafibrate for ovulation induction in patients with PCOS with dyslipidemia who were resistant to c...
journal_title:Gynecologic and obstetric investigation
pub_type: 临床试验,杂志文章
doi:10.1159/000316265
更新日期:2010-01-01 00:00:00