Stable engraftment of human female genital mucous membrane xenografts on SCID mice.

Abstract:

:We developed a model in which full-thickness human genital mucous membranes (fallopian tubes, endometrium) were heterotopically xenografted into the skin of severe combined immunodeficient (SCID) mice. The transplanted tissue retained its human phenotype for at least 4 weeks including the glandular epithelium, the lamina propria, and main parts of the grafted vessels. By using an occlusive chamber filled with covering phosphate-buffered saline we created a system that protected the moist human epithelial surface. This system will allow the study of the interaction of test substances, or of invasive, pathogenic microorganisms, with epithelial cells and other cellular components of the human genital mucosa under in vivo conditions.

journal_name

Gynecol Obstet Invest

authors

Kaufmann R,Rudolphi A,Boxberger HJ,Hainzl A,Rosenthal H,Reimann J

doi

10.1159/000292314

subject

Has Abstract

pub_date

1995-01-01 00:00:00

pages

97-100

issue

2

eissn

0378-7346

issn

1423-002X

journal_volume

40

pub_type

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