Stable engraftment of human female genital mucous membrane xenografts on SCID mice.


:We developed a model in which full-thickness human genital mucous membranes (fallopian tubes, endometrium) were heterotopically xenografted into the skin of severe combined immunodeficient (SCID) mice. The transplanted tissue retained its human phenotype for at least 4 weeks including the glandular epithelium, the lamina propria, and main parts of the grafted vessels. By using an occlusive chamber filled with covering phosphate-buffered saline we created a system that protected the moist human epithelial surface. This system will allow the study of the interaction of test substances, or of invasive, pathogenic microorganisms, with epithelial cells and other cellular components of the human genital mucosa under in vivo conditions.


Gynecol Obstet Invest


Kaufmann R,Rudolphi A,Boxberger HJ,Hainzl A,Rosenthal H,Reimann J




Has Abstract


1995-01-01 00:00:00












  • Conservative treatment of ectopic pregnancy and its effect on corpus luteum activity.

    abstract::Corpus luteum activity was monitored in 15 women undergoing nonsurgical management of ectopic pregnancy with local methotrexate injection followed by alternating oral methotrexate and citrovorum factor (group A, n = 8) or local methotrexate injection alone (group B, n = 7). All patients initially demonstrated a viable...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章


    authors: Shulman A,Maymon R,Zmira N,Lotan M,Holtzinger M,Bahary C

    更新日期:1992-01-01 00:00:00

  • Histological and ultrastructural pattern of cervical squamous cell carcinoma in a young woman.

    abstract::A rare type of cervical squamous cell carcinoma with pseudoglandular features occurred in a 22-year-old woman. Histological and ultrastructural characteristics of this tumor with keratinized cells as well as glandular mucin containing structures and intracellular luminal formations are presented. The problems associat...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章


    authors: Kivinen S,Stenbäck F

    更新日期:1983-01-01 00:00:00

  • CD9 gene variations are not associated with female infertility in humans.

    abstract:BACKGROUND/AIMS:To determine whether genetic alterations in the CD9 gene are associated with female infertility in humans. METHODS:We sequenced the entire coding region of this gene in 86 Japanese women with unexplained infertility and further conducted a case-control study of six tagging single nucleotide polymorphis...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章


    authors: Nishiyama S,Kishi T,Kato T,Suzuki M,Nishizawa H,Pryor-Koishi K,Sawada T,Nishiyama Y,Iwata N,Udagawa Y,Kurahashi H

    更新日期:2010-01-01 00:00:00

  • Association of apolipoprotein J gene 866C-->T polymorphism with preeclampsia and essential hypertension.

    abstract::The etiology of preeclampsia (PE) is unknown, but endothelial cell injury plays a pivotal role. Moreover, there is a significantly positive association between PE and later hypertension. Apolipoprotein J (apo J) plays an important role in stabilizing cell membranes at diverse fluid-tissue interfaces and might protect ...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章


    authors: Chen M,Yuan Z,Shan K

    更新日期:2005-01-01 00:00:00

  • Unexpected nature of a pelvic mass in pregnancy: Castleman's disease.

    abstract::The obstetrician is rarely confronted with a pregnant patient who presents with a large suspicious pelvic mass. Diagnostic tools are not always of value and laparotomy may be performed for obstetric and histopathologic reasons. In this article we present an interesting case of an unusual pelvic mass in pregnancy secon...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章


    authors: Başer I,Dilek S,Pabuçcu R,Ulgenalp I,Mermut S,Finci R

    更新日期:1989-01-01 00:00:00

  • Diagnostic aid of endometrium biopsy.

    abstract::The 784 cases, from which 701 complained of abnormal uterine bleeding, were reviewed by age groups, presenting symptoms, sex steroid medication and endometrial findings. Endometrial polyps and endometritis, which showed an incidence of 17.5 and 10.0%, respectively, were correlated with clinicopathologic findings. Peri...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章


    authors: van Bogaert LJ

    更新日期:1979-01-01 00:00:00

  • Prediction of high birthweight from maternal characteristics, symphysis fundal height and ultrasound biometry.

    abstract::The possibility to predict a large infant during pregnancy was assessed using data from a prospective cohort study of 537 singleton pregnancies with term deliveries. Maternal characteristics, symphysis fundal height and ultrasound measurements were used in multivariate analyses for the prediction of an infant with a b...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章


    authors: Wikström I,Bergström R,Bakketeig L,Jacobsen G,Lindmark G

    更新日期:1993-01-01 00:00:00

  • Value of perinatal audit in obstetric care in the developing world: a ten-year experience of the Maputo model.

    abstract::A decade of perinatal audit in the Maputo Central Hospital is reviewed with the objective of addressing the potential value of the audit process in monitoring the different constituents of morbidity and mortality in the perinatal period. The perinatal mortality showed a significant but transient change during the obse...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章


    authors: Bugalho A,Bergström S

    更新日期:1993-01-01 00:00:00

  • Does cord presentation on ultrasound predict cord prolapse?

    abstract:OBJECTIVE:To study the association of umbilical cord presentation found on antenatal ultrasound and the incidence of cord prolapse in labor. STUDY DESIGN:We reviewed the antenatal records of all deliveries in the Mount Sinai Hospital in a 5-year period and conducted two separate retrospective studies. In the first stu...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章


    authors: Ezra Y,Strasberg SR,Farine D

    更新日期:2003-01-01 00:00:00

  • Novel Nonsense Mutation in the NLRP7 Gene Associated with Recurrent Hydatidiform Mole.

    abstract:AIM:This study aimed to clarify the genetic and epigenetic features of recurrent hydatidiform mole (RHM) in Japanese patients. METHODS:Four Japanese isolated RHM cases were analyzed using whole-exome sequencing. Villi from RHMs were collected by laser microdissection for genotyping and DNA methylation assay of differe...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章


    authors: Ito Y,Maehara K,Kaneki E,Matsuoka K,Sugahara N,Miyata T,Kamura H,Yamaguchi Y,Kono A,Nakabayashi K,Migita O,Higashimoto K,Soejima H,Okamoto A,Nakamura H,Kimura T,Wake N,Taniguchi T,Hata K

    更新日期:2016-01-01 00:00:00

  • The integrity of cervical collagen during pregnancy and labor.

    abstract::The concentration of collagen in the human uterine cervix decreases during pregnancy. This change contributes to the ripening process, which facilitates cervical dilatation during labor. It has been suggested that cervical collagen is partly degraded at term and after delivery. In order to evaluate this hypothesis we ...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章


    authors: Uldbjerg N,Malmström A,Ekman G,Ulmsten U

    更新日期:1985-01-01 00:00:00

  • Fetal weight prediction by ultrasound measurements. A prospective study.

    abstract::Fetal weight prediction with ultrasonic measurements of biparietal diameter (BPD) and abdominal circumference (AC) using the equation by Shepard et al. [1982] was tested prospectively in 310 fetuses. Fetuses of all weight categories were included. The error of weight prediction was in the range of +684 to -880 g. One ...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章


    authors: Bistoletti P

    更新日期:1986-01-01 00:00:00

  • A case study of a pregnant patient with a congenital heart block accompanied by left isomerism and uncontrolled type 2 diabetes who was treated successfully with ritodrine.

    abstract::We present a case study of a patient with a congenital heart block associated with a left isomerism that was diagnosed during the 26th week of gestation. The mother had type 2 diabetes mellitus that was difficult to control during the early stages of the pregnancy. A fetal echocardiogram revealed an atrioventricular d...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章


    authors: Serikawa T,Ichikawa K,Kikuchi A,Takakuwa K,Tanaka K

    更新日期:2010-01-01 00:00:00

  • Risk Factors for Intrapartum Fever in Term Gestations and Associated Maternal and Neonatal Sequelae.

    abstract:AIM:To determine factors associated with intrapartum fever and to examine associated maternal and neonatal outcomes. METHODS:Retrospective study of patients between 360/7 and 420/7 gestational weeks who entered spontaneous or induced active labor and developed temperature ≥38°C; a similar group that did not develop fe...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章


    authors: Burgess APH,Katz JE,Moretti M,Lakhi N

    更新日期:2017-01-01 00:00:00

  • Patient satisfaction after laparoscopic total or supracervical hysterectomy.

    abstract:BACKGROUND/AIMS:To evaluate patient satisfaction after laparoscopic supracervical (LASH) or total hysterectomy (TLH). METHODS:Retrospective study of patient satisfaction after LASH or TLH. RESULTS:We studied 40 cases of LASH and another 40 of TLH. The age of the patients, marital status, education level and employmen...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章


    authors: Kafy S,Al-Sannan B,Kabli N,Tulandi T

    更新日期:2009-01-01 00:00:00

  • Ultrastructure of rabbit endosalpinx and glycoprotein pattern of the oviduct fluid in the presence of copper intrauterine devices.

    abstract::Oviduct fluid was collected from 24 mature female rabbits in estrus fitted with a copper intrauterine device (IUD) in one of the uterine horns by laparotomy and examined for total sugar and protein content. The percentage of total sugar in the dry protein-containing material from the experimental side was 7.3 compared...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章


    authors: David A,Levinsky H,Malik Z,Langzam Y,Feller N,Shaked P,Allalouf D

    更新日期:1982-01-01 00:00:00

  • Outpatient Hysteroscopic Polypectomy: Bipolar Energy System (Versapoint®) versus Mechanical Energy System (TRUCLEAR System®) - Preliminary Results.

    abstract:HYPOTHESIS:The new hysteroscopic system with mechanical energy is an effective outpatient technique for diagnosis and treatment that has certain advantages over conventional hysteroscopy in the management of endometrial polyps. OBJECTIVES:Our primary objective was to assess the total duration of hysteroscopy and polyp...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章,随机对照试验


    authors: Rovira Pampalona J,Degollada Bastos M,Mancebo Moreno G,Ratia Garcia E,Buron Pust A,Mateu Pruñonosa JC,Guerra Garcia A,Carreras Collado R,Bresco Torras P

    更新日期:2015-01-01 00:00:00

  • Comparison of Serum A Disintegrin and Metalloproteinase with Thrombospondin Motifs-19 Levels in Different Fertility Situations: Could It Be a Serum Marker of Ovarian Function and Oocyte Pool?

    abstract:BACKGROUND/AIMS:A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) enzymes take part in extracellular matrix (ECM) remodeling which has been shown to contribute to the ovulation and follicular functions. We aimed to compare serum levels of ADAMTS-19 in patients with different fertility situations. ...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章


    authors: Ersoy E,Özler S,Öztaş E,Ersoy AÖ,Ergin M,Tokmak A,Yilmaz N

    更新日期:2019-01-01 00:00:00

  • Magnetic resonance-visible polypropylene mesh for pelvic organ prolapse repair.

    abstract:AIM:To develop a magnetic resonance (MR)-visible mesh using iron oxides and prove visibility. METHODS:In a phantom study, a suitable iron oxide, Fe3O4 [iron(II,III) oxide] and FeOOH [iron(III) oxide-hydroxide], concentration was determined using relaxometric MR measurements of the transverse relaxation rates R2 and R2...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章


    authors: Brocker KA,Lippus F,Alt CD,Hallscheidt P,Zsolt F,Soljanik I,Lenz F,Bock M,Sohn C

    更新日期:2015-01-01 00:00:00

  • Fractal analysis of the maternal surface of the placenta: preliminary report.

    abstract:AIMS:The objective of this study was to determine whether the maternal surface of the placenta is fractal, and whether the mean fractal dimension differs according to the gestational age and clinically or pathologically different conditions. METHODS:Using digitized images of the maternal surface of 75 placentas, fract...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章


    authors: Shiba M,Kikuchi A,Hara K,Sunagawa S,Yoshida S,Takagi K,Ogiso Y

    更新日期:2007-01-01 00:00:00

  • Serum leptin profiles in the normal menstrual cycles and gonadotropin treatment cycles.

    abstract::Circulating levels of leptin, estradiol (E(2)) and progesterone (P(4)) throughout normal menstrual cycles (n = 13), and controlled, stimulated cycles (n = 33) were examined using sensitive specific radioimmunoassays in order to investigate the relationships between sex hormones (E(2), P(4)). Serum leptin levels during...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 临床试验,杂志文章


    authors: Yamada M,Irahara M,Tezuka M,Murakami T,Shima K,Aono T

    更新日期:2000-01-01 00:00:00

  • Diagnostic Relevance of Ferrokinetic Laboratory Markers in Anemic Pregnant Women.

    abstract:OBJECTIVES:Different forms of anemia are considered as the most frequent complication of the gestational period. By its etiology, pathogenesis, and clinical hematology, it is not a single disease. Among all forms of anemia occurring during pregnancy, iron deficiency anemia (IDA) is the most common, accounting for 80-95...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章


    authors: Aringazina R,Zharmakhanova G,Kurmanalina G,Bekkuzhin A,Kurmanalin B

    更新日期:2020-01-01 00:00:00

  • Role of T-cell cytokines in decidua and in cumulus oophorus during pregnancy.

    abstract::We focus on the roles of decidual and cumulus oophorus T cells. It was suggested that Th1-type cytokines (IFN-gamma and TNF-beta), which promote allograft rejection, may compromise pregnancy, whereas the Th2-type cytokines (IL-4, IL-5, IL-10) inhibiting the Th1 responses promote allograft tolerance and therefore may i...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章,评审


    authors: Piccinni MP

    更新日期:2007-01-01 00:00:00

  • Magnetic resonance imaging angiography in a case of eclampsia.

    abstract::We experienced a typical case of eclampsia. After the onset of eclampsia, we performed magnetic resonance imaging angiography (MRI angiography) to estimate the function of the cerebral artery. MRI angiography showed that spasm occurred in many cerebral arteries. The spasm was still observed in some arteries 13 day aft...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章


    authors: Kanayama N,Nakajima A,Maehara K,Halim A,Kajiwara Y,Isoda H,Masui T,Terao T

    更新日期:1993-01-01 00:00:00

  • Effect of the carbon dioxide laser on the oviducts of rabbits.

    abstract::Oviducts of 35 mature, white New Zealand rabbits were injured by a laser beam, using various powers from 25 to 40 W, and by a series of pulses of 1/10, 1/20 or 1/100 s duration. The contralateral oviducts served as controls and were injured at similar areas by a scalpel. The injured areas of both tubes were histologic...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章


    authors: David A,Nebel L,Serr DM,Czernobilsky B,Gaton E

    更新日期:1981-01-01 00:00:00

  • Human Chorionic Gonadotropin Regression Curves after Partial or Complete Molar Pregnancy in Flanders: Are They Different from Regression Curves from the Eighties?

    abstract:BACKGROUND/AIMS:We updated human chorionic gonadotropin (hCG) regression curves created in the eighties after evacuation of complete and partial molar (CM and PM, respectively) pregnancies using modern hCG assays. We created similar curves for patients in need of chemotherapy (gestational trophoblastic neoplasia [GTN])...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章


    authors: Delattre S,Han S,Moerman P,Billen J,Goffin F,Scharpé K,Vergote I

    更新日期:2018-01-01 00:00:00

  • Prenatal diagnosis of minute supernumerary marker chromosomes.

    abstract::The identification of supernumerary marker chromosomes (SMC) at prenatal diagnosis is problematic, particularly for the prediction of phenotype. The assessment of phenotypic risk is based on the size, morphology and origin of the SMC. Fluorescence in situ hybridization (FISH) characterization and family studies are al...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章


    authors: Cotter PD,Drexler K,Corley AL,Covert SM,Moland JS,Govberg IJ,Norton ME

    更新日期:2005-01-01 00:00:00

  • Angioleiomyoma originating from the ovary of an eleven-year-old premenarchal girl.

    abstract:BACKGROUND:Angioleiomyoma (ALM) is a rare, benign neoplasm involving the peripheral soft tissues. ALM has not previously been described to originate from the ovary. We present a case herein of a premenarchal girl with a large ALM originating from the ovary. CASE:An 11-year-old girl underwent a laparotomy during the co...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章


    authors: Hsu TL,Changchien CC,Huang CC,Lin H

    更新日期:2008-01-01 00:00:00

  • TNFalpha -308 C-->t and -863 C-->a polymorphisms and spermiogram characteristics.

    abstract:BACKGROUND:Genetic factors may play a role in male infertility. METHODS:In a prospective case-control study, we assessed the allele and genotype frequencies of the TNFalpha -308 C-->T and -863 C-->A polymorphisms, detected by PCR of sperm DNA, of 577 Caucasian men recruited in an infertility clinic. Semen sampling was...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章


    authors: Kurz C,Bentz EK,Denschlag D,Berner I,Keck C,Tempfer CB,Pietrowski D

    更新日期:2008-01-01 00:00:00

  • Women with gestational diabetes develop glucose intolerance with high frequency within one year postpartum.

    abstract:OBJECTIVE:To investigate the incidence of glucose intolerance postpartum in women with gestational diabetes (GDM) and assess body weight, cholesterol and triglyceride concentrations after delivery. METHODS:This was a study of an initial cohort of 100 women with GDM who were tested at 6 weeks, 6 months, and 1 year post...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章


    authors: Saucedo R,Zarate A,Basurto L,Hernandez M,Puello E,Campos S,Moreno E

    更新日期:2012-01-01 00:00:00