Immunosuppressant material in human seminal fluid. Inhibition of blast transformation and of NK activity by seminal fluid patients of a male infertility clinic.

Abstract:

:Human seminal plasma from normal or patients with abnormal parameters of the ejaculates contains an inhibitory material that expresses potent in vitro inhibitory activity on PHA-M-induced blast transformation and NK activity. Using the test of inhibition of NK activity, the semen samples from individuals with higher concentrations of fructose had higher inhibitory activity. The results described herein suggest that inhibitory activity for blast transformation may be present in the prostatic fluid while the NK inhibition aspects are correlated with the vesicle-marker (fructose). Inhibition of the immune responses by human seminal plasma of the effector functions indicates the interesting implication that soluble factors may indirectly protect against or promote human autoimmune infertility disease.

journal_name

Gynecol Obstet Invest

authors

Marcus ZH,Lunenfeld B,Weissenberg R,Lewin LM

doi

10.1159/000298834

subject

Has Abstract

pub_date

1987-01-01 00:00:00

pages

54-9

issue

1

eissn

0378-7346

issn

1423-002X

journal_volume

23

pub_type

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