Abstract:
BACKGROUND/AIMS:The transmembrane protein dystroglycan (DG) is known to anchor the cell membrane to the extracellular matrix, and is susceptible to cleavage by matrix metalloproteinases. This study tested the hypothesis that changes in DG abundance in fetal membranes (FM) occur late in gestation, with spontaneous rupture of membranes (SROM), and during labor. METHODS:FM were collected from a prospective cohort consisting of four groups of patients (term labor, term unlabored, preterm labor, and preterm unlabored). FM were subjected to immunohistochemical staining using antibodies specific for α- and β-DG subunits, and staining intensity was graded by a blinded pathologist. RESULTS:α- and β-DG staining was significantly decreased at term and after SROM (p < 0.05), but not in the presence of labor. CONCLUSIONS:Decreased DG intensity was seen in FM of patients at term and with SROM, but no change was observed with labor.
journal_name
Gynecol Obstet Investjournal_title
Gynecologic and obstetric investigationauthors
Theiler RN,Snyder RR,Theiler SKdoi
10.1159/000367894subject
Has Abstractpub_date
2015-01-01 00:00:00pages
244-9issue
4eissn
0378-7346issn
1423-002Xpii
000367894journal_volume
79pub_type
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