Abstract:
:Gestational diabetes (GD), defined as carbohydrate intolerance with onset or first recognition during pregnancy, has a prevalence of 7% and is a growing problem worldwide. Infants born to mothers with GD are more likely to be large for gestational age, incur traumatic birth injury, require a stay in the intensive care unit and develop postnatal metabolic disturbances. As the worldwide epidemic of obesity worsens, more women are entering pregnancy with metabolic alterations and preexisting insulin resistance, which is heightened by the hormonal milieu of pregnancy. The Hyperglycemia Adverse Pregnancy Outcome (HAPO) study has clearly shown that GD-related complications correlate with glycemic control. We will review the current understanding of the physiology of GD and the screening and treatment guidelines that are commonly utilized in clinical care. In addition, we will discuss the need for development of multiparametric models combining maternal clinical risk factors and biomarkers early in pregnancy to better stratify and predict risk of GD-related complications and offer targeted intervention.
journal_name
Gynecol Obstet Investjournal_title
Gynecologic and obstetric investigationauthors
Correa PJ,Vargas JF,Sen S,Illanes SEdoi
10.1159/000357616subject
Has Abstractpub_date
2014-01-01 00:00:00pages
145-9issue
3eissn
0378-7346issn
1423-002Xpii
000357616journal_volume
77pub_type
杂志文章,评审abstract::Sonography has achieved a position of preeminence in the diagnostic evaluation of molar gestation. However, little information is available about the serial change of the transvaginal sonographic features of molar pregnancy. We describe a case of complete hydatidiform mole, and present serial transvaginal views taken ...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000072082
更新日期:2003-01-01 00:00:00
abstract::In 15 normal mothers the stress effects of labor on zinc and copper distributions in erythrocytes and plasma were investigated. Lower levels of total zinc and of zinc derived from both carbonic anhydrase isoenzymes (CA-I and CA-II), especially from CA-I, in erythrocytes were obtained immediately after delivery. On the...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000298798
更新日期:1987-01-01 00:00:00
abstract::Implantation of intrauterine devices (IUDs) is associated with an increased incidence of uterine infection, probably as a result of vaginal bacteria entering the uterus at the time of insertion. To reduce the incidence of IUD-related infections, the incorporation of antimicrobial agents into the tail of the device was...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000010256
更新日期:2000-01-01 00:00:00
abstract::Uterine myoma leading to uremia in young women below 16 years of age is an extremely rare condition. On reviewing the literature we have not been able to find any case similar to the one described below. ...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000293043
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND:Epithelial ovarian carcinoma produces steroid hormones that may be of prognostic importance. The steroids are mainly bound to plasma albumin and sex hormone-binding globulin. Alterations in plasma protein levels influence hormonal effects. As plasma prealbumin may reflect changes in the patient's clinical st...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000292542
更新日期:1994-01-01 00:00:00
abstract::Holtzman, female rats with a plastic or copper IUD were maintained on either a dexamethasone solution (9.4 or 28 micrograms/rat/day) in the drinking water or on water alone. Animals were caged with males of proven fertility and subsequently killed at day 14 of pregnancy and the number of implantation sites counted. Bo...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000299826
更新日期:1980-01-01 00:00:00
abstract::Sixty postmenopausal women were randomly assigned to three types of treatment with intranasal salmon calcitonin (SCT) plus calcium 500 mg daily (group A: 100 IU daily of SCT; group B: 100 IU daily of SCT for alternate cycles of 2 months with a 1-month interval; group C: 100 IU daily of SCT for alternate cycles of 3 mo...
journal_title:Gynecologic and obstetric investigation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000294874
更新日期:1992-01-01 00:00:00
abstract::We report an extremely rare case of a 50-year-old woman with an adenocarcinoma arising within a urethral diverticulum. She could not be diagnosed correctly before operation and the microscopic pathological examination of the surgical specimen was the only indication showing the cancer origin. ...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000292307
更新日期:1995-01-01 00:00:00
abstract::Osteoporosis of the hip is a rare complication of pregnancy, the diagnosis of which can only be determined by radiologic means. Differentiation between osteonecrosis and osteoporosis remains problematic in some cases. Magnetic resonance imaging was reported as useful for the diagnosis of osteoporosis. Treatment of ost...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000052910
更新日期:2001-01-01 00:00:00
abstract::In vitro production of progesterone and estradiol by human corpora lutea of different ages was evaluated in the presence or absence of human chorionic gonadotrophin (HCG). Progesterone production by the luteal tissue was enhanced by as little as 0.1 IU/ml HCG and maximally stimulated by approximately 10 IU/ml HCG. Est...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000293698
更新日期:1988-01-01 00:00:00
abstract:BACKGROUND/AIMS:We updated human chorionic gonadotropin (hCG) regression curves created in the eighties after evacuation of complete and partial molar (CM and PM, respectively) pregnancies using modern hCG assays. We created similar curves for patients in need of chemotherapy (gestational trophoblastic neoplasia [GTN])...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000458523
更新日期:2018-01-01 00:00:00
abstract::We report a case of an unusual vesicovaginal stone. The dumb-bell-shaped stone created a ball valve effect in the fistula, therefore giving rise to only mild urinary leakage despite the large size of the fistula. ...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000064686
更新日期:2002-01-01 00:00:00
abstract::Endometriosis is a sex steroids-dependent disease. It has been postulated that certain genetic polymorphisms involved in sex steroids biosynthesis and metabolisms may be associated with increased risk of developing endometriosis. Despite a deluge of reports of positive associations of endometriosis with numerous polym...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章,meta分析,评审
doi:10.1159/000089011
更新日期:2006-01-01 00:00:00
abstract::An evaluation of the age distribution of erythrocytes in twin gestation was performed. Based on previous studies on age distribution of erythrocytes in late pregnancy, we have proposed that a more pronounced shift in age distribution of erythrocytes in twin pregnancy may be expected. We have used the density distribut...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000292618
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND:Progesterone is thought to mediate immune modulator effects by regulating uterine responsiveness. The aim of the study was to clarify the effect of transferrin and glycodelin A (former name PP14) as sialyl Lewis X-expressing glycoproteins on the release of progesterone by trophoblast cells in vitro. METHODS...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000080073
更新日期:2004-01-01 00:00:00
abstract::The long-term effects of valproic acid (VPA) on reproductive endocrine functions in women with epilepsy (WWE) were studied. Serum reproductive hormone concentrations, clinical findings and ovarian morphology were analyzed in 71 WWE who had been receiving antiepileptic drugs (AED) for a minimum of 2 years. Of the 71 WW...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000203537
更新日期:2009-01-01 00:00:00
abstract:AIM:To compare the effect of suprapubic and transurethral catheterization on postvoid residual volumes (PRVs) after cystocele repair. METHODS:126 women who underwent pelvic organ prolapse surgery including cystocele repair were randomized to suprapubic or transurethral catheterization. At the third postoperative day, ...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章,随机对照试验
doi:10.1159/000323827
更新日期:2011-01-01 00:00:00
abstract::An extremely rare case of partial hydatidiform mole located in the right Fallopian tube was diagnosed by ultrasonography and computed tomography. The lesion was excised, and the human chorionic gonadotropin (HCG) level in early morning urine fell below 1,000 IU/ml on postoperative day 11, and the serum HCG-beta level ...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000292708
更新日期:1993-01-01 00:00:00
abstract::This study was undertaken to evaluate the response to parenteral administration of iron in 62 pregnant patients with asiderotic anemia and mean initial hemoglobin (Hb) concentrations (Hb1) of 9.91+/-(SD) 1.13 g/dl. Iron (742+/-366 mg) was administered intravenously, and the response to treatment was classified accordi...
journal_title:Gynecologic and obstetric investigation
pub_type: 临床试验,杂志文章
doi:10.1159/000010109
更新日期:1999-01-01 00:00:00
abstract::The study's objective was to determine if using human chorionic gonadotropin (hCG) as a timing method for intrauterine insemination (IUI) in patients who make mature follicles but have cervical factor problems has a negative effect on pregnancy rates (PRs) (possibly by releasing an immature oocyte), or increases the r...
journal_title:Gynecologic and obstetric investigation
pub_type: 临床试验,杂志文章
doi:10.1159/000292447
更新日期:1994-01-01 00:00:00
abstract::Thyroxine-binding globulin (TBG) and free thyroxine (FT4) were studied in 172 apparently healthy women giving birth to malformed children. The malformations were divided into two groups: minor malformations (group A) and major malformations (group B). The blood samples were usually drawn in the first trimester. Group ...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000293608
更新日期:1989-01-01 00:00:00
abstract:AIMS:To construct in vitro models of normal uterine arterial vascular network through vascular corrosion casting and explore their characteristics and clinical significances. METHODS:Three sets of uterus, vagina and bilateral adnexa were perfused and cast via uterine artery and ovarian artery, using 25, 20 and 15% chl...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000245941
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND/AIMS:Some embryo implantation problems in patients with recurrent implantation failure may be explained by the inability of the embryo to hatch out of its zona pellucida. In this case-control study, a study group which had received modified quarter laser-assisted zona thinning (mQLAZT) was compared with a co...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000171068
更新日期:2009-01-01 00:00:00
abstract::Twenty-four women with second-trimester cervical incompetence underwent emergency cerclage. The appropriateness of cervical cerclage was analyzed according to a scoring system (Cervical Incompetence Scale; CIS) which measures the degree of cervical effacement, cervical dilatation and protrusion of fetal membranes into...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000293093
更新日期:1991-01-01 00:00:00
abstract:OBJECTIVES:The aim of this study is to evaluate oxidative protein damage (OPD) by investigating protein carbonyl (PCO) and nitrotyrosine (NT) levels, oxidative stress by total thiol (T-SH), erythrocyte glutathione (GSH) and nitric oxide (NO) levels in women receiving hormone replacement therapy (HRT). MATERIALS AND ME...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000067718
更新日期:2002-01-01 00:00:00
abstract::Penis and testicle amputation, vaginoplasty, and clitoroplasty are procedures that help male-to-female transsexuals to accept their body and to increase psychosocial well-being. We describe a successful correction of prolapse of the neovagina with abdominovaginal sacropexy in a male-to-female transsexual who had under...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000064559
更新日期:2002-01-01 00:00:00
abstract::One-sided artificial hydrosalpinx was caused in mature New Zealand rabbits by proximal and distal ligature. After 2 weeks the average secretion accumulation was 2.1 ml, after 8 weeks 6.3 ml. A fold relief could no longer be detected after 8 weeks. The light-microscopical study of the epithelium showed signs of cell de...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000299469
更新日期:1982-01-01 00:00:00
abstract::To determine the placental clearance of lactate and bicarbonate in sheep, the fetal side of an isolated cotyledon and the umbilical circulation of the total placenta were artificially perfused. The release and uptake of lactate and bicarbonate by the perfusion fluid and the fetomaternal concentration differences of th...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000299913
更新日期:1979-01-01 00:00:00
abstract::Minimal deviation adenocarcinoma (MDA) is a very rare variant of cervical adenocarcinoma, this pathological entity is composed of mucinous very-well-differentiated glands deeply invading cervical stroma, and often surrounded by a desmoplastic reaction. Despite its benign histological appearance, MDA is typically chara...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000327938
更新日期:2011-01-01 00:00:00
abstract::The obstetrician is rarely confronted with a pregnant patient who presents with a large suspicious pelvic mass. Diagnostic tools are not always of value and laparotomy may be performed for obstetric and histopathologic reasons. In this article we present an interesting case of an unusual pelvic mass in pregnancy secon...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000293507
更新日期:1989-01-01 00:00:00