Higher implantation rate using modified quarter laser-assisted zona thinning in repeated implantation failure.

Abstract:

BACKGROUND/AIMS:Some embryo implantation problems in patients with recurrent implantation failure may be explained by the inability of the embryo to hatch out of its zona pellucida. In this case-control study, a study group which had received modified quarter laser-assisted zona thinning (mQLAZT) was compared with a control group which had not received mQLAZT with respect to reproductive outcome. METHODS:Cycles from patients with a 4th fresh embryo transfer (ET) after 3 previously failed ET cycles (no beta-hCG detected) were included. Cases (group A, n = 53) included ET cycles from patients who received a 4th ET with fresh embryos after mQLAZT. Controls (group B, n = 86) included ET cycles from patients who had a 4th ET without mQLAZT. The clinical implantation rate and live birth rate per embryo transferred were measured. RESULTS:The clinical implantation rate with positive fetal heart beat per embryo transferred was significantly higher (p = 0.035) in group A (22/107 or 21%) than in group B (18/166 or 11%). CONCLUSION:The data of this case-control study suggest that mQLAZT can be effective in the treatment of patients with recurrent implantation failure, but need to be confirmed by randomized trials.

journal_name

Gynecol Obstet Invest

authors

Debrock S,Spiessens C,Peeraer K,De Loecker P,Willemen D,D'Hooghe TM

doi

10.1159/000171068

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

127-33

issue

2

eissn

0378-7346

issn

1423-002X

pii

000171068

journal_volume

67

pub_type

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