Plasma endothelin-1 levels during asphyxia in the fetal goat.

Abstract:

:The changes in fetal carotid arterial plasma levels of endothelin-1, catecholamines, PO2, PCO2 and pH were measured after intermittent repetitive umbilical cord occlusion in late gestation pregnant goats (n = 9). Endothelin-1 levels increased to 3.58 +/- 0.28 pg/ml immediately after the onset of fetal hypoxia, a level significantly higher than the respective values in the control period (p < 0.05). The elevation of fetal plasma endothelin-1 levels correlated inversely with carotid arterial PO2 (r = -0.41, p < 0.05) and pH (r = - 0.43, p < 0.05). The results suggest that increased endothelin-1 levels may contribute to the maintenance of the fetal circulation during fetal asphyxia.

journal_name

Gynecol Obstet Invest

authors

Takada H,Yoneyama Y,Power GG,Araki T

doi

10.1159/000291966

subject

Has Abstract

pub_date

1996-01-01 00:00:00

pages

217-21

issue

4

eissn

0378-7346

issn

1423-002X

journal_volume

42

pub_type

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