Tn and sialyl-Tn antigens as potential prognostic markers in human ovarian carcinoma.

Abstract:

OBJECTIVE:Carcinoma-associated Tn and sialyl-Tn antigens have been shown to aid in the prediction of tumor aggressiveness. The purpose of this study was to evaluate the prognostic value of Tn and sialyl-Tn antigen expression in human ovarian carcinoma. METHODS:Formalin-fixed, paraffin-embedded tissue sections from 32 primary ovarian carcinomas, 6 benign and 2 normal ovarian tissues were immunostained using monoclonal antibodies against Tn and sialyl-Tn antigens and a streptavidin-biotin-peroxidase method Immunostainings were assessed semiquantitatively and the measurements were then correlated with the established prognostic factors of ovarian carcinoma. i.e. disease stage and histological grade. RESULTS:Of the 32 ovarian carcinomas, 22 (69%) expressed Tn and 28 (87.5%) sialyl-Tn antigens. Immunostaining measures for Tn antigen were significantly associated with the clinical stage (p < or = 0.02) and histological grade (p < or = 0.05) of the tumors. The results for sialyl-Tn antigen revealed more significant associations with the clinical stage (p < or = 0.002) and histological grade (p < or = 0.007). The clinical stage and histologic grade of the tumors were also highly correlated with each other. Similarly, combined Tn and sialyl-Tn antigen expression revealed significant correlations with the prognostic factors. Benign and normal ovarian tissues showed no reactive Tn and sialyl-Tn antigen. CONCLUSIONS:The extent of Tn and sialyl-Tn antigen expression in primary ovarian carcinoma may contribute to the prognosis of the disease.

journal_name

Gynecol Obstet Invest

authors

Ogawa H,Ghazizadeh M,Araki T

doi

10.1159/000292284

subject

Has Abstract

pub_date

1996-01-01 00:00:00

pages

278-83

issue

4

eissn

0378-7346

issn

1423-002X

journal_volume

41

pub_type

杂志文章
  • Peritoneal fluid leukotriene B4 and prostaglandin E2 in acute salpingitis.

    abstract::Concentrations of leukotriene B4 (LTB4) and prostaglandin E2 (PGE2) in peritoneal fluid were measured in 19 women with suspected acute pelvic inflammatory disease. Acute salpingitis was verified by laparoscopy in 16 cases; 11 of them had isolation of microbes from the peritoneal cavity. Means (+/- SD) levels of perito...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000293338

    authors: Heinonen PK,Aine R,Seppälä E

    更新日期:1990-01-01 00:00:00

  • Intrauterine balloon catheter for ultrasound evaluation of pelvic masses. Enhancement of uterus localization.

    abstract::Pelvic masses can be diagnosed by pelvic ultrasonography. Difficulties may be encountered to identify the organ origin of a pelvic mass. An intrauterine marker is proposed to facilitate the diagnosis by the exact localization of the uterus and its relationship to other pelvic findings. ...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000298777

    authors: Zakut H,Achiron R

    更新日期:1987-01-01 00:00:00

  • Follow-up of growth-retarded children born by elective cesarean section before 33 weeks.

    abstract::25 singleton pregnancies were terminated by cesarean section between 28 and 33 weeks of gestation because of suspected growth retardation and abnormal unstressed cardiotocograms. Only infants with birth weights below the tenth centile were considered. 17 survived and were neurologically examined at 2.5-7 years of age....

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000299030

    authors: Huisjes HJ,Baarsma R,Hadders-Algra M,Touwen BC

    更新日期:1985-01-01 00:00:00

  • Ophthalmic artery velocimetry in preeclampsia.

    abstract::Our objective was to compare ophthalmic artery pulsatility index values from normal pregnant women with those from preeclampsia patients. The ophthalmic artery of 20 normotensive pregnant women, 7 mildly preeclamptic and 2 severely preeclamptic patients was studied once with color Doppler flow imaging and pulsed Doppl...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000292298

    authors: Hata T,Senoh D,Hata K,Kitao M

    更新日期:1995-01-01 00:00:00

  • Serotonin-induced vasoconstriction in human placental chorionic veins: interaction with prostaglandin F2 alpha.

    abstract::In vitro experiments using isolated rings and perfused segments of human chorionic veins, were designed to determine the effects of serotonin and their interaction with PGF2 alpha on vascular tension and perfusion pressure. These vessels responded vigorously with high sensitivity to the vasoconstrictor effects of sero...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000292671

    authors: González C,Cruz MA,Gallardo V,Albornoz J,Bravo I

    更新日期:1993-01-01 00:00:00

  • Peritoneal fluid concentrations of ciliary neurotrophic factor, a gp130 cytokine, in women with endometriosis.

    abstract::Ciliary neurotrophic factor (CNTF) is a gp130 neuroregulatory cytokine belonging to the interleukin-6-type cytokine superfamily. Several lines of evidence suggest that the concentrations of interleukin-6 are elevated in the peritoneal fluid of endometriosis patients. To our knowledge, no study on whether this might al...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000072694

    authors: Suzumori N,Suzumori K

    更新日期:2003-01-01 00:00:00

  • Efficacy of ER-alpha polymorphisms and the intrafollicular IGF system for predicting pregnancy in IVF-ET patients.

    abstract:AIMS:To evaluate the efficacies of the estrogen receptor-alpha (ER-alpha) gene polymorphisms and of the intrafollicular insulin-like growth factor (IGF) system for predicting pregnancy in in vitro fertilization and embryo transfer (IVF-ET) patients. METHODS:A total of 96 patients undergoing IVF-ET were included in thi...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000162104

    authors: Choi YS,Kim SH,Ku SY,Jee BC,Suh CS,Choi YM,Kim JG,Moon SY

    更新日期:2009-01-01 00:00:00

  • Effects of caffeine ingestion during pregnancy.

    abstract::We studied the effects of caffeine ingestion during pregnancy. A total number of 9,921 healthy pregnant women with a gestational age after 24 weeks were subjected to the study. The women who drank more than 5 cups of coffee per day had a high incidence of impending abortion, premature labor, and fetuses small for gest...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000299032

    authors: Furuhashi N,Sato S,Suzuki M,Hiruta M,Tanaka M,Takahashi T

    更新日期:1985-01-01 00:00:00

  • Doppler flow velocity waveforms and vasoactive effects of serotonin in human umbilical arteries.

    abstract::The vasoactive effect of serotonin was investigated by in vitro perfusion in human umbilical arteries in which antenatal Doppler ultrasound examination revealed abnormal velocity waveforms. The results were compared to those obtained in preparations from normotensive uncomplicated term pregnancies as well as from pret...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000052885

    authors: Haugen G,Rognerud H

    更新日期:2001-01-01 00:00:00

  • Cervico-oculo-acousticus syndrome with pregnancy.

    abstract::Cervico-oculo-acousticus syndrome is a very rare entity with only 21 cases described in the world literature. A study of a case of this syndrome with pregnancy is presented. This primigravida, in addition to the classical triad of the syndrome, had other dysmorphic features such as short stature (141 cm), and marked t...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000293115

    authors: Sholapurkar SL,Dhall GI

    更新日期:1991-01-01 00:00:00

  • Taxol Improves Pre-Implantation Development Potential of Mouse Embryos.

    abstract:AIM:The objective of the present study was to investigate the development of mouse embryos and the chromosomal status after the pre-implantation treatment with paclitaxel (Taxol) based on the reports that indicate Taxol improves the developmental potential of vitrified human and mouse oocytes. METHODS:Outbred female m...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000502820

    authors: Esmaeilzadeh K,Gourabi H,Sheidai M,Fakhri M,Bazrgar M

    更新日期:2020-01-01 00:00:00

  • Relationship between mean arterial pressure and parameters derived from blood flow velocity waveforms in the systemic circulation of fetal sheep.

    abstract::In 8 fetal sheep under anesthesia, we examined the relationship between the fetal aorta blood flow velocity waveform and fetal mean arterial pressure after administration of norepinephrine and angiotensin II. It was hypothesized that the pulsatility index (PI) of the waveform would change during fetal hypertension. Me...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000292583

    authors: Muijsers GJ,van Huisseling H,Hasaart TH

    更新日期:1993-01-01 00:00:00

  • The Efficacy of Dienogest in the Treatment of Simple Endometrial Hyperplasia without Atypia.

    abstract:AIM:The aim of the study was to compare the effectiveness of dienogest (DIE), depo medroxyprogesterone 17-acetate (MPA), and micronized progesteron (MP) regimens for treatment of simple endometrial hyperplasia (EH) without atypia. METHODS:One hundred and twenty premenopausal patients aged between 35 and 55, with simpl...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章,随机对照试验

    doi:10.1159/000477618

    authors: Uysal G,Acmaz G,Madendag Y,Cagli F,Akkaya H,Madendag I,Karakilic EU

    更新日期:2018-01-01 00:00:00

  • Maternal and perinatal outcome in nulliparous women aged 35 and older.

    abstract:OBJECTIVE:To compare the maternal and perinatal outcome of nulliparous women 35 years and older at the time of delivery with nulliparous women 25-29 years old. METHODS:A retrospective review of maternal and newborn records of singleton gestations only for first birth in women aged 35 and older (study group n = 143) we...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000064689

    authors: Ziadeh SM

    更新日期:2002-01-01 00:00:00

  • The importance of the removal of the intrauterine device in genital colonization by actinomyces.

    abstract:OBJECTIVE:To determine whether, in addition to treatment with antibiotics, it is necessary to remove the intrauterine device (IUD) to eliminate genital colonization by Actinomyces. METHODS:A randomized clinical trial was carried out. Patients were divided into two groups. The intervention group did not have their IUDs...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000052955

    authors: Bonacho I,Pita S,Gómez-Besteiro MI

    更新日期:2001-01-01 00:00:00

  • Effects of add-back therapy on bone mineral density and pyridinium crosslinks in patients with endometriosis treated with gonadotropin-releasing hormone agonists.

    abstract::Treatment of endometriosis with gonadotropin-releasing hormone agonists (GnRHa) is limited to 6 months because of possible adverse effects on bone metabolism. We designed a randomized, double-blind, placebo-controlled, prospective study of 27 patients with endometriosis who were given GnRHa with or without hormone add...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000010059

    authors: Gnoth CH,Gödtke K,Freundl G,Godehardt E,Kienle E

    更新日期:1999-01-01 00:00:00

  • Ultrastructure of rabbit endosalpinx and glycoprotein pattern of the oviduct fluid in the presence of copper intrauterine devices.

    abstract::Oviduct fluid was collected from 24 mature female rabbits in estrus fitted with a copper intrauterine device (IUD) in one of the uterine horns by laparotomy and examined for total sugar and protein content. The percentage of total sugar in the dry protein-containing material from the experimental side was 7.3 compared...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000299449

    authors: David A,Levinsky H,Malik Z,Langzam Y,Feller N,Shaked P,Allalouf D

    更新日期:1982-01-01 00:00:00

  • Use of highly evacuated Redon drains after gynecologic laparotomies.

    abstract::Highly evacuated (980 mbar) wound drainage systems according to Redon were used in 100 gynecologic laparotomies. In 96% of cases, no flask exchange was required before the system was removed. Bacteriological specimens from various locations of the Redon system showed minimal colonization with pathogenic bacteria. No c...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000293758

    authors: Grillo M,Riedel HH,Lehmann-Willenbrock E,Höller C

    更新日期:1988-01-01 00:00:00

  • Gonadotrophin dependence of steroidogenesis by human corpora lutea of different ages during the menstrual cycle.

    abstract::In vitro production of progesterone and estradiol by human corpora lutea of different ages was evaluated in the presence or absence of human chorionic gonadotrophin (HCG). Progesterone production by the luteal tissue was enhanced by as little as 0.1 IU/ml HCG and maximally stimulated by approximately 10 IU/ml HCG. Est...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000293698

    authors: Yamoto M,Ikoma H,Nakano R

    更新日期:1988-01-01 00:00:00

  • Should we continue performing intrauterine inseminations in the year 2004?

    abstract::This review summarizes the existing evidence regarding intrauterine insemination (IUI) as a treatment for cervical hostility, male and unexplained subfertility. IUI in natural cycles has been proven effective in patients with cervical hostility and moderate male subfertility. IUI in cycles with mild ovarian hyperstimu...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章,评审

    doi:10.1159/000080492

    authors: Cohlen BJ

    更新日期:2005-01-01 00:00:00

  • Chronic intrauterine bleeding and fetal growth at less than 32 weeks of gestation.

    abstract::Placental hemosiderin deposition representing intrauterine bleeding at least 24-48 h before delivery is detected frequently in prematurity. The objective of this study was to assess incidence and site of histologic evidence of intrauterine bleeding in association with fetal growth in prematurity. Placentas of consecut...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000010289

    authors: Sherer DM,Salafia CM

    更新日期:2000-01-01 00:00:00

  • Anxiety of infertile women undergoing IVF-ET: relation to the grief process.

    abstract::The psychological state of 102 infertile women undergoing in vitro fertilization and embryo transfer was investigated. The levels of anxiety were measured by the state trait anxiety inventory and the manifest anxiety scale. The process of accepting infertility and attitudes toward treatment were explored by a semistru...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000291510

    authors: Mori E,Nadaoka T,Morioka Y,Saito H

    更新日期:1997-01-01 00:00:00

  • Immunoradiometric studies with a monoclonal antibody against an estrogen-receptor-related protein in human breast cancer.

    abstract::The concentration of P29, a phosphoprotein related to estradiol receptor (RE), was measured by an immunoradiometric assay in human breast cancer cytosol and the results compared with the levels of RE and progesterone receptors (RP), as measured by the classical ligand-binding assay. Good linear correlation was found b...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000293689

    authors: Cano A,Rivera J,Parrilla JJ,Abad L

    更新日期:1988-01-01 00:00:00

  • Altered growth hormone secretion during oral contraception.

    abstract::Serum profiles of growth hormone (GH) were recorded for 24 h in 9 young healthy women before and during treatment with monophasic, combined contraceptives. During treatment, there was a change in GH secretion towards a pattern of smaller peaks at a higher frequency. The mean peak amplitude decreased from 11.2 to 7.3 m...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000293276

    authors: Karlsson R,Edén S,von Schoultz B

    更新日期:1990-01-01 00:00:00

  • Effect of LHRH and its analogues on the progesterone secretion of human granulosa cells in vitro.

    abstract::Progesterone secretion of cultured human granulosa cells treated with LHRH or its analogues was measured. Granulosa cells were also stimulated with LH, FSH, cAMP or forskolin. No differences could be observed in the progesterone basal secretion of cultures treated with or without LHRH or its analogues and after the va...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000292765

    authors: Török A,Hamori M,Bódis J,Cledon P,Tinneberg HR,Hanf V

    更新日期:1992-01-01 00:00:00

  • Relationship between changes in contraction and cyclic AMP contents under long-term application of ritodrine in pregnant rat myometrium.

    abstract::The relationship between contraction changes and cAMP production under long-term application of ritodrine was investigated using longitudinal muscle strips of pregnant (Day 21) rat uterus. Cellular cAMP gradually increased up to 20 min, then decreased to the control level and fluctuated after 90 min in the presence of...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000293119

    authors: Kawarabayashi T,Tsukamoto T,Hamasaki Y,Kaneko Y,Ikeda M,Sugimori H

    更新日期:1991-01-01 00:00:00

  • Gestational diabetes: an evaluation of serum fructosamine as a screening test in a high-risk population.

    abstract:AIM:To evaluate the value of serum fructosamine as a screening test for gestational diabetes mellitus (GDM). METHODS:849 pregnant women underwent the one-step 75 g oral glucose tolerance test (OGTT) for universal screening of GDM. The fasting serum fructosamine (cFruc) was assessed using the area under the receiver op...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000318705

    authors: Agarwal MM,Dhatt GS,Othman Y,Ljubisavljevic MR

    更新日期:2011-01-01 00:00:00

  • Parity-related prevalence of rhesus antigens among Mozambican parturients.

    abstract::The potential risk of rhesus alloimmunization and the ensuing risk of fetal death with increasing parity were investigated in two groups of parturients; primiparous and grand multiparous (para > or = 5) women with liveborns. It was hypothesized that significantly fewer women of the latter than of the former group woul...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000292744

    authors: Pereira C,Axemo P,Bergström S,Säfwenberg J

    更新日期:1992-01-01 00:00:00

  • Preeclampsia and maternal heart rate variability.

    abstract::Maternal heart rate variability was evaluated by means of 24-hour Holter ECG monitoring in three groups of patients (15 preeclamptic, 15 women hospitalized due to other complications and 15 normal ambulatory pregnant women) in the 28th-33rd week of gestation. Heart rate variability was estimated by time and frequency ...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000009949

    authors: Eneroth E,Storck N

    更新日期:1998-01-01 00:00:00

  • Differences in mRNA expression of endothelin-1, c-fos and c-jun in placentas from normal pregnancies and pregnancies complicated with preeclampsia and/or intrauterine growth retardation.

    abstract::A defect in placental function has been suggested to be associated both with preeclampsia (PE), with or without concomitant intrauterine growth retardation (IUGR), and with IUGR as a single entity. Our aim was to compare the mRNA expression of the growth-related protooncogenes c-fos and c-jun and the vasoconstrictor a...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000291494

    authors: Faxén M,Nasiell J,Lunell NO,Blanck A

    更新日期:1997-01-01 00:00:00