Immunoradiometric studies with a monoclonal antibody against an estrogen-receptor-related protein in human breast cancer.

Abstract:

:The concentration of P29, a phosphoprotein related to estradiol receptor (RE), was measured by an immunoradiometric assay in human breast cancer cytosol and the results compared with the levels of RE and progesterone receptors (RP), as measured by the classical ligand-binding assay. Good linear correlation was found between P29 and RE, but not RP. Tumors which were positive for both RE and RP had a higher P29 mean value than RE-negative, RP-negative tumors. Menopausal status of the patients influenced the result, since premenopausal women had lower mean concentrations or were P29-positive less frequently than postmenopausal women. RE-negative, RP-positive tumors tended to have positive P29 levels. The correlation between RE and P29 corroborates results obtained with other techniques and supports a role for P29 in predicting response to hormonal treatment.

journal_name

Gynecol Obstet Invest

authors

Cano A,Rivera J,Parrilla JJ,Abad L

doi

10.1159/000293689

subject

Has Abstract

pub_date

1988-01-01 00:00:00

pages

166-70

issue

2

eissn

0378-7346

issn

1423-002X

journal_volume

26

pub_type

杂志文章
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    pub_type: 杂志文章,随机对照试验

    doi:10.1159/000377700

    authors: Rovira Pampalona J,Degollada Bastos M,Mancebo Moreno G,Ratia Garcia E,Buron Pust A,Mateu Pruñonosa JC,Guerra Garcia A,Carreras Collado R,Bresco Torras P

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    doi:10.1159/000327938

    authors: Ferrandina G,Carbone A,Macchia G,Petrillo M,Lucidi A,Morganti AG

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    pub_type: 临床试验,杂志文章

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    pub_type: 杂志文章

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    pub_type: 杂志文章

    doi:10.1159/000292675

    authors: Bergström S,Fernandes A,Schwalbach J,Perez O,Miyar R

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    pub_type: 杂志文章

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  • Tobacco smoking impairs the local immunosurveillance in the uterine cervix. An immunohistochemical study.

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    pub_type: 杂志文章

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    pub_type: 杂志文章,随机对照试验

    doi:10.1159/000091842

    authors: Kashanian M,Akbarian A,Baradaran H,Samiee MM

    更新日期:2006-01-01 00:00:00

  • Anxiety of infertile women undergoing IVF-ET: relation to the grief process.

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    pub_type: 杂志文章

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  • Characterization of P4, a natural inhibitor of cellular cytotoxicity reaction in pregnant women.

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    pub_type: 杂志文章

    doi:10.1159/000298991

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    doi:10.1159/000097139

    authors: Huang LW,Pan HS,Lin YH,Chou KY

    更新日期:2007-01-01 00:00:00

  • Oxytocin and female sexuality.

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    pub_type: 杂志文章,评审

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    更新日期:1995-01-01 00:00:00

  • Modified hysteroscopic myomectomy of large submucous fibroids.

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    journal_title:Gynecologic and obstetric investigation

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    journal_title:Gynecologic and obstetric investigation

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  • Atrial natriuretic peptide and cyclic guanosine-3',5'-monophosphate in normal and pathological pregnancies.

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    journal_title:Gynecologic and obstetric investigation

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  • CD44+/CD24+-Expressing Cervical Cancer Cells and Radioresistant Cervical Cancer Cells Exhibit Cancer Stem Cell Characteristics.

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    pub_type: 杂志文章

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    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000299256

    authors: Spona J,Gitsch E,Salzer H,Karrer K

    更新日期:1983-01-01 00:00:00

  • The importance of the removal of the intrauterine device in genital colonization by actinomyces.

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    pub_type: 临床试验,杂志文章,随机对照试验

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