Tobacco smoking impairs the local immunosurveillance in the uterine cervix. An immunohistochemical study.

Abstract:

:Previous reports have supported an association between tobacco smoking and cervical neoplasia. Our observations show an association between smoking and a reduction of the numerical densities of Langerhans cells and of helper/inducer T lymphocytes in the squamous epithelia of the transformation zone of the uterine cervix. This suggests a local impairment of cell-mediated immunity by smoking. This immunosuppressive effect could support the concept that smoking is an independent risk factor for cervical neoplasia.

journal_name

Gynecol Obstet Invest

authors

Poppe WA,Ide PS,Drijkoningen MP,Lauweryns JM,Van Assche FA

doi

10.1159/000292372

subject

Has Abstract

pub_date

1995-01-01 00:00:00

pages

34-8

issue

1

eissn

0378-7346

issn

1423-002X

journal_volume

39

pub_type

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