Endometrial carcinoma: histopathology, survival, and exogenous estrogens.

Abstract:

:Pathologic material was reviewed and survival data were obtained on 182 of the endometrial cancer patients reported in our previous study (1975) to compare histopathologic characteristics and clinical behavior (survival) between endometrial adenocarcinoma in estrogen users and nonusers. In addition, relative risk estimates of estrogen-associated endometrial carcinoma were calculated from review results. This work identifies estrogen users as having a significant higher frequency of low-grade tumor with an associated improved survival even when numerous clinical parameters are taken into account. Other histologic or clinical characteristics of the disease did not relate significantly to estrogen use after taking account of histologic grade. The marked increase in endometrial cancer risk among estrogen users was confirmed by the pathology review (relative risk 6.44) and is evident even when attention is restricted to disease that has invaded the myometrium (relative risk 6.09).

journal_name

Gynecol Obstet Invest

authors

Smith DC,Prentice RL,Bauermeister DE

doi

10.1159/000299600

subject

Has Abstract

pub_date

1981-01-01 00:00:00

pages

169-79

issue

4

eissn

0378-7346

issn

1423-002X

journal_volume

12

pub_type

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