Uterine rupture in twin pregnancy with normal fetus and complete hydatidiform mole.

Abstract:

:We describe a rare case of complete hydatidiform mole with twin live fetus (CHMTF) confirmed by histopathology, flow cytometry and polymerase chain reaction techniques. No malformations were observed, fetal karyotype was normal and β-human chorionic gonadotropin levels were high (>100,000 IU/ml). The patient was informed of the risks and decided to continue with the pregnancy, but at week 15, she had to undergo hysterectomy due to uterine rupture. She subsequently developed persistent trophoblastic disease (PTD) with pulmonary metastases that required treatment with polychemotherapy. Patients with CHMTF should be informed of all known risks, including the considerable risk of PTD, which is similar to or, even higher than that associated with a singleton complete mole. The risk does not appear to be increased by continuing the pregnancy. Because so few series have been published, there is a lack of evidence-based clinical management guidelines. To our knowledge, this is the first report of uterine rupture in CHMTF.

journal_name

Gynecol Obstet Invest

authors

Sánchez-Ferrer ML,Hernández-Martínez F,Machado-Linde F,Ferri B,Carbonel P,Nieto-Diaz A

doi

10.1159/000355566

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

127-33

issue

2

eissn

0378-7346

issn

1423-002X

pii

000355566

journal_volume

77

pub_type

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