Abstract:
:Subcutaneous heparin and plasma infusion were successfully used during an induced abortion in a young woman with familial antithrombin-III deficiency and a history of severe thrombotic episodes. :Women with herditary antithrombin-3 deficiency are exposed to a considerable risk of thrombosis during periods of thrombogenic stress, such as labour, delivery or abortion. This study describes treatment with heparin and subcutaneous infusion of plasma in a pregnant 25 year old, AT-3 deficient woman undergoing abortion. The patient belonged to a family in which thrombotic episodes were not uncommon; the patient herself had experienced thrombosis during her first pregnancy. At the 3rd month of gestation it was decided to interrupt pregnancy. Prophylactic treatment with subcutaneous heparin, 5000 IU 3 times a day, began 10 days before abortion. On the day of the abortion, she received 900 ml of fresh plasma as a source of AT-3 over a period of 7 hours, and an additional amount of 5000 IU heparin shortly before the abortion. The abortion and injection of methylergometrin caused a significant reduction of platelet number; changes in plasma AT-3 were minimal. On the 4th day after abortion the platelet number increased to pretreatment level, and heaprin treatment was stopped on the 12th day. This study demonstrates that subcutaneous infusion of fresh plasma is a safe prophylactic treatment for AT-3 deficient patients exposed to thrombogenic stress.
journal_name
Gynecol Obstet Investjournal_title
Gynecologic and obstetric investigationauthors
Jespersen Jdoi
10.1159/000299612subject
Has Abstractpub_date
1981-01-01 00:00:00pages
267-71issue
5eissn
0378-7346issn
1423-002Xjournal_volume
12pub_type
杂志文章abstract::Fetal echocardiographic and Doppler ultrasonographic prospective studies were performed in utero on 299 babies delivered at Hirata Municipal Hospital, Shimane, Japan, from May 1984 to June 1986. Two or three ultrasonographic examinations were performed on each fetus from 20 weeks of gestation to term. Three congenital...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000293682
更新日期:1988-01-01 00:00:00
abstract::The long-term effects of valproic acid (VPA) on reproductive endocrine functions in women with epilepsy (WWE) were studied. Serum reproductive hormone concentrations, clinical findings and ovarian morphology were analyzed in 71 WWE who had been receiving antiepileptic drugs (AED) for a minimum of 2 years. Of the 71 WW...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000203537
更新日期:2009-01-01 00:00:00
abstract::We developed a model in which full-thickness human genital mucous membranes (fallopian tubes, endometrium) were heterotopically xenografted into the skin of severe combined immunodeficient (SCID) mice. The transplanted tissue retained its human phenotype for at least 4 weeks including the glandular epithelium, the lam...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000292314
更新日期:1995-01-01 00:00:00
abstract::Our purpose was to determine whether intrauterine sonography with high-frequency, real-time miniature transducer (20 MHz) is useful for the diagnosis of gynecologic disorders. The study consisted of 37 women: 8 normal volunteers, 2 with molar pregnancy, 4 fibromyoma, 4 endometrial polyp, 1 intrauterine adhesion, 1 sep...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000010072
更新日期:1999-01-01 00:00:00
abstract::This study deals with the effects of smoking on serum ceruloplasmin and its ferroxidase activity in pregnant women. The mean value (+/- SD) of serum ceruloplasmin in women smokers during pregnancy is significantly higher (p < 0.01) in comparison to that of nonsmokers, whereas the ferroxidase activity of ceruloplasmin ...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000291880
更新日期:1996-01-01 00:00:00
abstract:BACKGROUND/AIMS:Adenomyosis is a common condition with a poorly understood pathogenesis. Recent data suggest that it may be an epigenetic disease. This study investigated the expression and localization of class I histone deacetylases (HDACs) in women with and without adenomyosis. METHODS:The ectopic and homologous eu...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000336409
更新日期:2012-01-01 00:00:00
abstract::We report a case of an unusual vesicovaginal stone. The dumb-bell-shaped stone created a ball valve effect in the fistula, therefore giving rise to only mild urinary leakage despite the large size of the fistula. ...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000064686
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND/AIMS:Previous studies on the effects of estrogen on sclerostin regulation were conducted in postmenopausal women in humans or animals following estrogen treatment or induced estrogen deficiency. The aim of this study was to evaluate the effects of sex hormones on serum sclerostin levels in premenopausal wome...
journal_title:Gynecologic and obstetric investigation
pub_type: 临床试验,杂志文章
doi:10.1159/000347013
更新日期:2013-01-01 00:00:00
abstract::Our objective was to evaluate the efficacy and safety of labor induction in women with a breech presentation, and an unripe cervix. We conducted a retrospective, matched-paired study on patients with breech presentation and an unripe cervix (n = 23), who underwent induction of labor using extra-amniotic saline instill...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000010029
更新日期:1998-01-01 00:00:00
abstract::In 121 women attending the infertility clinic between 1978 and 1982, 127 cycles with luteal phases of 10 days or more were investigated by a complete basal body temperature (BBT) chart, three plasma progesterone assays taken between 11 and 4 days before menses, and a dated endometrial biopsy (EB) taken at the time of ...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000299140
更新日期:1984-01-01 00:00:00
abstract::Immunocytochemical study in paraffin sections of human endometrium showed that the receptor contents for both oestrogen and progesterone receptors were lower than in the frozen sections although the staining patterns were similar in these two section types. Pretreating the specimens with proteolytic enzymes like tryps...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000292422
更新日期:1995-01-01 00:00:00
abstract:PURPOSE:To analyze the effects and potential benefits of a single midcycle dose of follicle-stimulating hormone (FSH) prior to human chorionic gonadotropin (hCG) administration during unstimulated in vitro fertilization (IVF) cycles. METHODS:Twenty-five cycles from 20 patients receiving 150 IU of FSH 42-44 h and 10,00...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000291825
更新日期:1997-01-01 00:00:00
abstract::The influence of metronidazole on some strains of facultatively anaerobic bacteria was studied. In high doses similar to those used for local treatment the growth of some strains was clearly suppressed, moreover there was an inhibition of hemolysis in hemolytic strains even when they were found to be resistant to the ...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000300975
更新日期:1978-01-01 00:00:00
abstract::Serum samples were collected from 199 patients attending a gynaecological clinic, colposcopy specimens being taken at the same time for routine pathology of paraffin sections which ranged from normal, through the degrees of dysplasia to carcinoma in situ. Other parameters noted were age, number of pregnancies and time...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000299470
更新日期:1982-01-01 00:00:00
abstract:BACKGROUND/AIMS:To evaluate the degree of pain during and after office hysteroscopy with combined intracervical and intrauterine anesthesia compared to intracervical anesthesia only. METHODS:We evaluated the amount of pain experienced during office hysteroscopy using combined local intracervical and intrauterine anest...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000252957
更新日期:2010-01-01 00:00:00
abstract::In 15 normal mothers the stress effects of labor on zinc and copper distributions in erythrocytes and plasma were investigated. Lower levels of total zinc and of zinc derived from both carbonic anhydrase isoenzymes (CA-I and CA-II), especially from CA-I, in erythrocytes were obtained immediately after delivery. On the...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000298798
更新日期:1987-01-01 00:00:00
abstract:OBJECTIVES:To investigate the signs, symptoms and changes in the vaginal milieu that could be associated with cervical human papillomavirus infection (CHPI). STUDY DESIGN:Women (n = 972) attending for contraceptive advice were tested for human papillomavirus in cervical samples. Results of gynecological history, exami...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000291818
更新日期:1997-01-01 00:00:00
abstract::We measured three selected components of the fibrinolytic system in amniotic fluid of 36 parturient women, i.e. the antigen of tissue plasminogen activator (tPA) and antigens of plasminogen activator inhibitor of type 1 (PAI-1) and type 2 (PAI-2). The ELISA method was used. During labour, the level of each of the stud...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000292387
更新日期:1995-01-01 00:00:00
abstract::A dietary approach has proven to be effective in alleviating symptoms of premenstrual syndrome. In our previous studies, magnesium improved premenstrual irritability and mood scoings. In this double-blind, placebo-controlled study, we evaluated the effects of a new dietetic preparation (Sillix Donna, Giuliani) in 40 p...
journal_title:Gynecologic and obstetric investigation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000291836
更新日期:1997-01-01 00:00:00
abstract::The relationship between age and urodynamic parameters was studied cross-sectionally in a group of 28 women in whom clinically and urodynamically both stress incontinence and detrusor instability were excluded (no proven incontinence, NPI) and in a group, matched for age, with genuine stress incontinence (GSI). At all...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000294858
更新日期:1992-01-01 00:00:00
abstract::The concentration of collagen in the human uterine cervix decreases during pregnancy. This change contributes to the ripening process, which facilitates cervical dilatation during labor. It has been suggested that cervical collagen is partly degraded at term and after delivery. In order to evaluate this hypothesis we ...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000298975
更新日期:1985-01-01 00:00:00
abstract::In an acute fetal lamb model the relation between arterial PCO2 (PaCO2), transcutaneous PCO2 (tcPCO2) and pH was studied at different conditions of stress. Occlusion of the maternal common iliac artery for 8 min, umbilical cord obstruction for 5 min and placental embolization were performed subsequently, every time wi...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000291808
更新日期:1997-01-01 00:00:00
abstract::The effects of estradiol-17 beta (E2) and clomiphene citrate (CC) on pituitary-uterine function in ovariectomized (OVX) rats were compared in two experiments. In experiment 1, CC completely blocked E2 stimulation of uterine weight when administered concurrently for 10 and 30 days. In experiment 2, content of total (oc...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000293095
更新日期:1991-01-01 00:00:00
abstract::The nuclear DNA content of 20 anembryonic pregnancies was studied by flow cytometry from paraffin embedded tissue blocks. An abnormal amount of DNA content was found in 8 of the cases. This was a significantly higher percentage than encountered in spontaneous abortions studied by the same population (40 and 9%, respec...
journal_title:Gynecologic and obstetric investigation
pub_type: 临床试验,杂志文章
doi:10.1159/000010149
更新日期:1999-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:To assess the presence of human papillomavirus (HPV) DNA in vulvar papillomatosis, since some women with this complaint have symptoms associated with HPV infection, such as itching, burning, and dyspareunia. GOAL:To reassure the patients that they do not have a transmissible viral disease, by...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000292350
更新日期:1995-01-01 00:00:00
abstract:BACKGROUND/AIMS:Limited information is available regarding the quantity of blood loss associated with uncomplicated transvaginal oocyte retrieval. The aim of the present study was evaluating the quantity of such a loss. METHODS:One hundred and fifty consecutive women undergoing oocyte retrieval were recruited. They un...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000158649
更新日期:2009-01-01 00:00:00
abstract::Two women, one 27 years old (case 1) and the other 20 years old (case 2), were evaluated due to right lower quadrant pain. The lactate dehydrogenase level was increased in case 1 and the dihydroepiandostrone level was increased in both cases. Preoperative transvaginal ultrasonography revealed solid masses, but the tum...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000053009
更新日期:2002-01-01 00:00:00
abstract::Placental proteins such as human chorionic gonadotrophin (hCG), Schwangerschaftsprotein 1 (SP1) and pregnancy-associated plasma protein A (PAPP-A) are found in the blood of pregnant women and in subjects suffering from cancer. They can also be found in the blood of healthy non-pregnant women and in the seminal fluid o...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000298985
更新日期:1985-01-01 00:00:00
abstract::The mechanisms by which anti-phospholipid antibodies (aPLs) may induce pregnancy losses, intrauterine growth retardation and pregnancy-induced hypertension are not clearly understood. Moreover, there is a controversy regarding the possible direct effects of these antibodies on the physiology of the placenta since the ...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:
更新日期:2004-01-01 00:00:00
abstract::Serum profiles of growth hormone (GH) were recorded for 24 h in 9 young healthy women before and during treatment with monophasic, combined contraceptives. During treatment, there was a change in GH secretion towards a pattern of smaller peaks at a higher frequency. The mean peak amplitude decreased from 11.2 to 7.3 m...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000293276
更新日期:1990-01-01 00:00:00