Termination of pregnancy in a woman with hereditary antithrombin deficiency under antithrombotic protection with subcutaneous heparin and infusion of plasma.

Abstract:

:Subcutaneous heparin and plasma infusion were successfully used during an induced abortion in a young woman with familial antithrombin-III deficiency and a history of severe thrombotic episodes. :Women with herditary antithrombin-3 deficiency are exposed to a considerable risk of thrombosis during periods of thrombogenic stress, such as labour, delivery or abortion. This study describes treatment with heparin and subcutaneous infusion of plasma in a pregnant 25 year old, AT-3 deficient woman undergoing abortion. The patient belonged to a family in which thrombotic episodes were not uncommon; the patient herself had experienced thrombosis during her first pregnancy. At the 3rd month of gestation it was decided to interrupt pregnancy. Prophylactic treatment with subcutaneous heparin, 5000 IU 3 times a day, began 10 days before abortion. On the day of the abortion, she received 900 ml of fresh plasma as a source of AT-3 over a period of 7 hours, and an additional amount of 5000 IU heparin shortly before the abortion. The abortion and injection of methylergometrin caused a significant reduction of platelet number; changes in plasma AT-3 were minimal. On the 4th day after abortion the platelet number increased to pretreatment level, and heaprin treatment was stopped on the 12th day. This study demonstrates that subcutaneous infusion of fresh plasma is a safe prophylactic treatment for AT-3 deficient patients exposed to thrombogenic stress.

journal_name

Gynecol Obstet Invest

authors

Jespersen J

doi

10.1159/000299612

subject

Has Abstract

pub_date

1981-01-01 00:00:00

pages

267-71

issue

5

eissn

0378-7346

issn

1423-002X

journal_volume

12

pub_type

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