Abstract:
:The effects of estradiol-17 beta (E2) and clomiphene citrate (CC) on pituitary-uterine function in ovariectomized (OVX) rats were compared in two experiments. In experiment 1, CC completely blocked E2 stimulation of uterine weight when administered concurrently for 10 and 30 days. In experiment 2, content of total (occupied and unoccupied) uterine nuclear estrogen receptors was increased by E2, but not by CC, compared to OVX controls. Only a fraction of the nuclear receptors was occupied in E2-treated rats, whereas all of these receptor sites were occupied in CC-treated rats. In addition, uterine cytoplasmic estrogen receptors were increased by E2 and diminished by CC treatment. Both E2 and CC were effective in preventing the postovariectomy rise in serum luteinizing hormone (LH) and follicle-stimulating hormone (FSH), although LH was always inhibited to a greater extent than FSH. After 30 days of treatment, pituitary gonadotropins were also substantially reduced by E2 and CC, suggesting that long-term treatment decreased both pituitary synthesis and release. An increase in pituitary weight observed in E2-treated rats only was due largely to the stimulation of lactotropes, as serum prolactin was increased. In summary, although CC and E2 similarly depressed pituitary gonadotropin secretion, they exhibited marked differences in the stimulation and occupancy of uterine estrogen receptors and the stimulation of pituitary prolactin secretion.
journal_name
Gynecol Obstet Investjournal_title
Gynecologic and obstetric investigationauthors
Brown JL,Byrd SJ,Mitchell AS,Nelson MF,Young RL,Chakraborty PKdoi
10.1159/000293095subject
Has Abstractpub_date
1991-01-01 00:00:00pages
23-9issue
1eissn
0378-7346issn
1423-002Xjournal_volume
31pub_type
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journal_title:Gynecologic and obstetric investigation
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journal_title:Gynecologic and obstetric investigation
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journal_title:Gynecologic and obstetric investigation
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journal_title:Gynecologic and obstetric investigation
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doi:10.1159/000355566
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journal_title:Gynecologic and obstetric investigation
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doi:10.1159/000293043
更新日期:1991-01-01 00:00:00
abstract::The cardiovascular and metabolic responses during acute fetal hypoxia were studied in 7 pregnant sheep near term. Complete reduction of uterine flow (UBF) for 180 s was performed in 13 experiments by inflating a balloon positioned in the maternal aorta. Fetal heart rate (FHR), systolic and diastolic blood pressure (BP...
journal_title:Gynecologic and obstetric investigation
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更新日期:1983-01-01 00:00:00
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journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000493129
更新日期:2019-01-01 00:00:00
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journal_title:Gynecologic and obstetric investigation
pub_type: 临床试验,杂志文章
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journal_title:Gynecologic and obstetric investigation
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journal_title:Gynecologic and obstetric investigation
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doi:10.1159/000071525
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journal_title:Gynecologic and obstetric investigation
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journal_title:Gynecologic and obstetric investigation
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doi:10.1159/000298787
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journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000298825
更新日期:1987-01-01 00:00:00
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journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000098198
更新日期:2007-01-01 00:00:00
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journal_title:Gynecologic and obstetric investigation
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doi:10.1159/000293003
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doi:10.1159/000292298
更新日期:1995-01-01 00:00:00
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journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000480454
更新日期:2018-01-01 00:00:00
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journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000299082
更新日期:1984-01-01 00:00:00
abstract::The ovarian morphology in 149 patients with the clinical syndrome of polycystic ovaries (group I) is described. The ovaries from 10 age-matched women (group II) with no signs of ovarian disorder were investigated as a reference material. The number of cysts documented for group I was twice that of the reference group ...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000293771
更新日期:1988-01-01 00:00:00
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journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
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journal_title:Gynecologic and obstetric investigation
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journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000083680
更新日期:2005-01-01 00:00:00
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journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000292491
更新日期:1994-01-01 00:00:00
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journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章,评审
doi:10.1159/000292030
更新日期:1996-01-01 00:00:00
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journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000365084
更新日期:2014-01-01 00:00:00
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journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000292572
更新日期:1994-01-01 00:00:00
abstract:OBJECTIVE:MIB 1 is a new monoclonal antibody which recognizes nuclei of proliferating cells throughout the cell cycle except during the G0 and early G1 phases. In the present study we analyzed the MIB 1 immunostaining as an index of cellular proliferation in cervical intraepithelial neoplasia (CIN) and microinvasive ca...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000291977
更新日期:1996-01-01 00:00:00
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journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000338892
更新日期:2012-01-01 00:00:00
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journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000010256
更新日期:2000-01-01 00:00:00