Effects of a yeast-based dietary supplementation on premenstrual syndrome. A double-blind placebo-controlled study.

Abstract:

:A dietary approach has proven to be effective in alleviating symptoms of premenstrual syndrome. In our previous studies, magnesium improved premenstrual irritability and mood scoings. In this double-blind, placebo-controlled study, we evaluated the effects of a new dietetic preparation (Sillix Donna, Giuliani) in 40 patients affected by mild to moderate premenstrual syndrome. Premenstrual symptoms were scored in both follicular and luteal phases, at baseline, at 2nd, 4th and 6th month of treatment by using the Menstrual Distress Questionnaire (MDQ). Twenty patients were randomised to receive the active preparation and 20 placebo. MDQ scores at baseline were similar in the two groups. Five patients of the placebo group dropped out because of treatment failure. No side effects were observed. Both treatments reduced symptoms already in the 2nd month, but the active preparation was more effective at all time controls (p < 0.05); at the 6th month it significantly reduced premenstrual MDQ scores to 18% of baseline values, placebo only to 73%. These data demonstrate that Sillix Donna is effective in reducing premenstrual distress.

journal_name

Gynecol Obstet Invest

authors

Facchinetti F,Nappi RE,Sances MG,Neri I,Grandinetti G,Genazzani A

doi

10.1159/000291836

subject

Has Abstract

pub_date

1997-01-01 00:00:00

pages

120-4

issue

2

eissn

0378-7346

issn

1423-002X

journal_volume

43

pub_type

临床试验,杂志文章,随机对照试验
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