Abstract:
BACKGROUND/AIMS:Adenomyosis is a common condition with a poorly understood pathogenesis. Recent data suggest that it may be an epigenetic disease. This study investigated the expression and localization of class I histone deacetylases (HDACs) in women with and without adenomyosis. METHODS:The ectopic and homologous eutopic endometrium of 50 women with adenomyosis and the endometrium of 18 age- and menstrual phase-matched women without adenomyosis were used for immunohistochemical analysis. Tissue sections were immunostained with HDAC1, -2, and -3. Microscopic evaluation to assess the presence and localization of HDAC1-3 throughout the menstrual cycle in both eutopic endometrial and endometriotic tissues of women with adenomyosis was performed and compared with the normal endometrium. RESULTS:We found that, compared with the normal endometrium, immunoreactivity against HDAC1 and HDAC3 was higher in both the eutopic and the ectopic endometrium. Increased HDAC2 in the eutopic endometrium was found to be associated with the severity of dysmenorrhea. CONCLUSION:Given the potential wide-ranging effect of histone deacetylation on gene expression, these findings suggest that HDACs may be involved in adenomyosis. They also suggest the possibility that HDAC2 may be involved in dysmenorrhea and its severity and that HDACs may be potential therapeutic targets in adenomyosis.
journal_name
Gynecol Obstet Investjournal_title
Gynecologic and obstetric investigationauthors
Liu X,Nie J,Guo SWdoi
10.1159/000336409subject
Has Abstractpub_date
2012-01-01 00:00:00pages
50-5issue
1eissn
0378-7346issn
1423-002Xpii
000336409journal_volume
74pub_type
杂志文章abstract::The efficacy of three protocols of endometrial preparation (spontaneous cycles, A: artificial preparation, B; ovarian stimulation, C) for cryopreserved-thawed human embryo transfer (CT-ET). The implantation and clinical pregnancy rates per cycle in 236 women undergoing 381 consecutive CT-ETs were evaluated according t...
journal_title:Gynecologic and obstetric investigation
pub_type: 临床试验,杂志文章
doi:10.1159/000292274
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journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
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journal_title:Gynecologic and obstetric investigation
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journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章,随机对照试验
doi:10.1159/000337713
更新日期:2012-01-01 00:00:00
abstract::This manuscript discusses the diagnosis and imaging of adenomyotic disease of the retroperitoneal space, a pathology that we have defined as retroperitoneal adenomyotic disease (RAD). By prospective analysis, comparing barium enema, magnetic resonance imaging (MRI) and transrectal ultrasonography, we distinguished thr...
journal_title:Gynecologic and obstetric investigation
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abstract::Sonography has achieved a position of preeminence in the diagnostic evaluation of molar gestation. However, little information is available about the serial change of the transvaginal sonographic features of molar pregnancy. We describe a case of complete hydatidiform mole, and present serial transvaginal views taken ...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
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更新日期:2003-01-01 00:00:00
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journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章,meta分析
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更新日期:2018-01-01 00:00:00
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journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000010086
更新日期:1999-01-01 00:00:00
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journal_title:Gynecologic and obstetric investigation
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journal_title:Gynecologic and obstetric investigation
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journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000294858
更新日期:1992-01-01 00:00:00
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journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000010218
更新日期:2000-01-01 00:00:00
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journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
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更新日期:2009-01-01 00:00:00
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journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000052936
更新日期:2001-01-01 00:00:00
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journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000292053
更新日期:1996-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1159/000496608
更新日期:2019-01-01 00:00:00
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journal_title:Gynecologic and obstetric investigation
pub_type: 临床试验,杂志文章
doi:10.1159/000010149
更新日期:1999-01-01 00:00:00
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journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000292387
更新日期:1995-01-01 00:00:00
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journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000329335
更新日期:2012-01-01 00:00:00
abstract::To evaluate both the incidence of c-myc gene mutation and the relationship of this finding to the clinico-pathologic characteristics of patients with cervical cancer, a polymerase chain reaction (PCR)-based heteroduplex gel electrophoresis method was used to screen DNA extracted from 102 cervical invasive carcinomas r...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000291505
更新日期:1997-01-01 00:00:00
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journal_title:Gynecologic and obstetric investigation
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journal_title:Gynecologic and obstetric investigation
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2001-01-01 00:00:00
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journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000291415
更新日期:1997-01-01 00:00:00
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journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000010289
更新日期:2000-01-01 00:00:00
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journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000356960
更新日期:2014-01-01 00:00:00
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journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章,meta分析
doi:10.1159/000213048
更新日期:2009-01-01 00:00:00
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journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000291535
更新日期:1997-01-01 00:00:00
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journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000010158
更新日期:1999-01-01 00:00:00
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journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000162104
更新日期:2009-01-01 00:00:00
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journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000299023
更新日期:1985-01-01 00:00:00