Abstract:
:In the present study we have measured the concentrations of interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) in preovulatory follicular fluid (FF) samples obtained from patients undergoing ovulation induction with human menopausal gonadotropin/human chorionic gonadotropin. In 13 of the 24 (54%) FF samples obtained from 20 patients, TNF-alpha was detected. In contrast, IL-1 beta was observed in none of the 16 samples assessed. In the samples with detectable levels of TNF-alpha, the mean concentration was 40.1 pg/ml (range 20-74 pg/ml). In addition, we found an association between the presence of TNF-alpha in the FF and the serum level of 17 beta-estradiol (E2) and progesterone (P). The E2 and P levels were significantly lower in patients with detectable levels of TNF-alpha in FF than in patients with no detectable TNF-alpha in FF. In summary, the present study shows the presence of TNF-alpha and the absence IL-1 beta in hyperstimulated human preovulatory FF. In addition, our results show an association between the presence of TNF-alpha in FF and low E2 and P levels in serum, suggesting a role for TNF-alpha in the regulation of human steroidogenesis.
journal_name
Gynecol Obstet Investjournal_title
Gynecologic and obstetric investigationauthors
Punnonen J,Heinonen PK,Teisala K,Kujansuu E,Jansen CT,Punnonen Rdoi
10.1159/000294853keywords:
subject
Has Abstractpub_date
1992-01-01 00:00:00pages
80-4issue
2eissn
0378-7346issn
1423-002Xjournal_volume
33pub_type
杂志文章abstract:OBJECTIVE:To determine the effects of the nitric oxide (NO) precursor L-arginine on the airway NO concentration in patients with preeclampsia. METHODS:NO was measured by a noninvasive chemiluminescence technique in air sampled directly from nasal and oral cavities during expiration before and during L-arginine infusio...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000010040
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND:Progesterone is thought to mediate immune modulator effects by regulating uterine responsiveness. The aim of the study was to clarify the effect of transferrin and glycodelin A (former name PP14) as sialyl Lewis X-expressing glycoproteins on the release of progesterone by trophoblast cells in vitro. METHODS...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000080073
更新日期:2004-01-01 00:00:00
abstract::A total of 171 consecutive high-risk parturients in Maputo Central Hospital were studied regarding post-partum contraceptive choice in order to plan a new post-natal clinic approach in maternal health care. It was found that contraceptive interest was much less in women with experience of child loss than in women with...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000294887
更新日期:1992-01-01 00:00:00
abstract::The Special Programme of Research in Human Reproduction (HRP), co-sponsored by the UNDP, UNFPA, WHO, and the World Bank, is celebrating 40 years of activities with an expansion of its mandate and new co-sponsors. When it began, in 1972, the main focus was on evaluating the acceptability, effectiveness, and safety of e...
journal_title:Gynecologic and obstetric investigation
pub_type: 历史文章,杂志文章,评审
doi:10.1159/000343067
更新日期:2012-01-01 00:00:00
abstract::Deep dyspareunia, often described as pain resulting from pelvic thrusting during sexual intercourse, is relatively common and has many causes. To date, feasible surgical interventions for deep dyspareunia are very rare. The two procedures which have been mentioned in the literature for the treatment of deep dyspareuni...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000087562
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:The aim of this study is to assess the clinical effectiveness and safety of hyaluronic acid gel for the prevention of postoperative intrauterine adhesions (IUAs). METHODS:PubMed, Cochrane Library, Embase and ClinicalTrials.gov databases were searched for randomized controlled trials. RESULTS:Six RCTs with ...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章,meta分析
doi:10.1159/000486674
更新日期:2018-01-01 00:00:00
abstract::Of 903 surgically treated patients with endometriosis the disease recurred in 132 cases (14.6%) during the follow-up period of 6-10 years. The re-operation was performed within 1 year after the primary operation for 7 patients, within 1-5 years for 91 patients and more than 5 years after the primary surgery for 34 pat...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000299851
更新日期:1980-01-01 00:00:00
abstract:INTRODUCTION:The role of defective fimbrio-ovarian relation in cases of unexplained infertility has not been extensively studied. The aim of the study was to assess the role of fimbrio-ovarian relation as an investigative modality in women with unexplained infertility. We also aimed to evaluate the efficacy of superovu...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000086004
更新日期:2005-01-01 00:00:00
abstract:AIM:To evaluate the clinical application of the new Hologic quantitative foetal fibronectin (qfFN) bedside test for the prediction of spontaneous preterm birth (sPTB) in patients with symptoms suggestive of spontaneous threatened preterm labour (sPTL). METHODS:A prospective observational study with 154 pregnant women ...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000480235
更新日期:2018-01-01 00:00:00
abstract::Amniotic fluids from women in West Virginia were evaluated for the presence of antibacterial activity by a bioassay technique. 41% of 32 third trimester samples were inhibitory. Evaluation of additional test organisms emphasized differences in susceptibility of various bacterial strains; two isolates of Escherichia co...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000299390
更新日期:1983-01-01 00:00:00
abstract::Our purpose was to determine whether intrauterine sonography with high-frequency, real-time miniature transducer (20 MHz) is useful for the diagnosis of gynecologic disorders. The study consisted of 37 women: 8 normal volunteers, 2 with molar pregnancy, 4 fibromyoma, 4 endometrial polyp, 1 intrauterine adhesion, 1 sep...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000010072
更新日期:1999-01-01 00:00:00
abstract::Hyaluronan (HA), a high molecular weight polysaccharide, is a major component of connective tissue and is thus present in the extracellular matrix of most tissues. Increased serum concentrations have been reported in association with pre-eclampsia and liver malfunction, amongst other disorders. We have performed histo...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000052986
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND/AIM:To evaluate the efficacy and tolerability of postoperative depot medroxyprogesterone acetate (DMPA) versus postoperative continuous oral contraceptive (OC) pills in the treatment of endometriosis-associated pain. METHODS:After a conservative surgery, 84 patients with symptomatic endometriosis were rando...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章,随机对照试验
doi:10.1159/000337713
更新日期:2012-01-01 00:00:00
abstract::Choriocarcinoma coexistent with an intrauterine pregnancy is rare and requires decisions affecting mother and child to treat this aggressive tumor. An instance of this situation is presented to highlight clinical circumstances that warrant departure from accepted dogma. Pathologic aspects of choriocarcinoma are also d...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000363234
更新日期:2015-01-01 00:00:00
abstract::Glycogen, glucose, some nucleosides and purine base derivatives were determined in biopsies from 10 term pregnant women undergoing elective cesarean sections before labor. The concentrations were compared in the biopsies which were cut from isthmus and fundus of the uterus and m. rectus abdominis. M. rectus biopsies h...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000010086
更新日期:1999-01-01 00:00:00
abstract::We report an extremely rare case of a 50-year-old woman with an adenocarcinoma arising within a urethral diverticulum. She could not be diagnosed correctly before operation and the microscopic pathological examination of the surgical specimen was the only indication showing the cancer origin. ...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000292307
更新日期:1995-01-01 00:00:00
abstract:BACKGROUND/AIMS:To compare the efficacy and safety of trocar-site infiltration with lidocaine and no intervention for postoperative pain relief after diagnostic laparoscopy. METHODS:A randomized clinical trial of women with infertility scheduled for diagnostic laparoscopy without additional procedures in Life Institut...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章,随机对照试验
doi:10.1159/000490565
更新日期:2019-01-01 00:00:00
abstract::We have previously described the identification of the human decidua-associated protein hDP200 as a rheumatoid factor [1]. Assuming that rheumatoid factor binds to Fc of immunoglobulins, the existence of high-molecular-weight complexes was studied in decidual extract, pooled uterine fluid from proliferative and early ...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000292272
更新日期:1996-01-01 00:00:00
abstract::Scanning electron microscopy of cryofractured immature intermediate villi showed numerous intercommunicating channels in the central region of the stroma, oriented mostly parallel to the major axis of the villus. In the stromal channels, numerous Hofbauer cells were present and their aspect and position inside the cha...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000299056
更新日期:1984-01-01 00:00:00
abstract:BACKGROUND:This study is aimed at comparing the early diagnostic accuracy of maternal blood white blood cell (WBC) count, C-reactive protein (CRP) and procalcitonin in predicting early onset neonatal sepsis (EONS) among early preterm premature rupture of membrane (PPROM) pregnancies. METHODS:A total of 57 consecutive ...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000446949
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND/AIMS:To determine the clinicopathological characteristics and potentially associated outcomes in patients diagnosed with serous adenocarcinoma of the uterine cervix. METHODS:The records of surgically-treated patients with pathological stage pT1b-2b serous adenocarcinoma were reviewed. RESULTS:Of 12 patient...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章,评审
doi:10.1159/000329319
更新日期:2012-01-01 00:00:00
abstract:AIM:To compare outcomes after laparoscopic ovarian cystectomy versus fenestration/coagulation or laser ablation for the treatment of endometriomas. METHODS:Studies were identified by searching the PubMed, EMBASE, SCOPUS, and Cochrane Central Register of Controlled Trials databases using the terms ovarian, endometrioma...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章,meta分析
doi:10.1159/000351165
更新日期:2013-01-01 00:00:00
abstract:AIMS:To summarize the clinical features, perioperative management and maternal and neonatal outcomes of patients with acute fatty liver of pregnancy (AFLP) and to discuss the management of anesthesia in these patients. METHODS:This study was a retrospective review over a period of 5 years and 9 months; 28 cases from t...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000351565
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the effectiveness of five methods including the ThinPrep cytological test (TCT), liquid-based cytology, the human papillomavirus (HPV) test, detection of the TERC and C-MYC genes and visual inspection with acetic acid/Lugol's iodine (VIA/VILI) for opportunistic cervical cancer screening, and to ex...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000371760
更新日期:2015-01-01 00:00:00
abstract:AIM:To compare the effect of suprapubic and transurethral catheterization on postvoid residual volumes (PRVs) after cystocele repair. METHODS:126 women who underwent pelvic organ prolapse surgery including cystocele repair were randomized to suprapubic or transurethral catheterization. At the third postoperative day, ...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章,随机对照试验
doi:10.1159/000323827
更新日期:2011-01-01 00:00:00
abstract::We focus on the roles of decidual and cumulus oophorus T cells. It was suggested that Th1-type cytokines (IFN-gamma and TNF-beta), which promote allograft rejection, may compromise pregnancy, whereas the Th2-type cytokines (IL-4, IL-5, IL-10) inhibiting the Th1 responses promote allograft tolerance and therefore may i...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章,评审
doi:10.1159/000101738
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVE:To compare embryo transfer (ET) technique based on catheter rotation during its withdrawal in cases with unexplained infertility in a prospective, randomized trial (NCT03097042). METHODS:Two hundred intracytoplasmic sperm injection (ICSI) patients undergoing ET with cleaving or blastocyst-stage fresh embryos...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章,随机对照试验
doi:10.1159/000489493
更新日期:2018-01-01 00:00:00
abstract::We present the case of a female fetus aborted in the 20th week of gestation due to severely dysplastic kidneys, anhydramnios and hydranencephalus. The combination of these malformations is extremely rare, resulting in only 4 cases described so far. Our case is the first ever presented in a female showing polycystic-dy...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章,评审
doi:10.1159/000291522
更新日期:1997-01-01 00:00:00
abstract::Adenoma malignum (minimum deviation adenocarcinoma) is a rare neoplasma of the uterine cervix, the diagnosis of wich cannot be determined by cervical smear. Recently, magnetic resonance imaging (MRI) was reported as useful for its diagnosis, but differentiation of adenoma malignum from deep-seated nabothian cysts rema...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000009959
更新日期:1998-01-01 00:00:00
abstract::In vitro experiments using isolated rings and perfused segments of human chorionic veins, were designed to determine the effects of serotonin and their interaction with PGF2 alpha on vascular tension and perfusion pressure. These vessels responded vigorously with high sensitivity to the vasoconstrictor effects of sero...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000292671
更新日期:1993-01-01 00:00:00