Serous adenocarcinoma of the uterine cervix: a clinicopathological study of 12 cases and a review of the literature.

Abstract:

BACKGROUND/AIMS:To determine the clinicopathological characteristics and potentially associated outcomes in patients diagnosed with serous adenocarcinoma of the uterine cervix. METHODS:The records of surgically-treated patients with pathological stage pT1b-2b serous adenocarcinoma were reviewed. RESULTS:Of 12 patients with serous adenocarcinoma who underwent radical hysterectomy, five had pT1b1N0 disease, two pT1b1N1, two pT1b2N0, and three pT2bN1. The 5-year overall survival rate for patients with or without parametrial involvement (pT2b vs. pT1b) was 0 and 89%, respectively. The 3-year recurrence-free survival rate for those with or without parametrial involvement was 33 and 89%, respectively. Four patients suffered recurrence, namely one of those who had pT1b (1/9, 11%) and 3 of those who had pT2b disease (100%). The sites of recurrence of pT2b disease were outside the pelvis in all 3 patients. Of these, 2 (67%) had peritoneal spread and 1 distant node metastasis. CONCLUSION:While patients with pathological stage pT1b disease may have a relatively favorable outcome after radical surgery, those with more advanced disease have a poor prognosis because of extra-pelvic recurrence.

journal_name

Gynecol Obstet Invest

authors

Togami S,Kasamatsu T,Sasajima Y,Onda T,Ishikawa M,Ikeda S,Kato T,Tsuda H

doi

10.1159/000329319

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

26-31

issue

1

eissn

0378-7346

issn

1423-002X

pii

000329319

journal_volume

73

pub_type

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