Treatment patterns and outcomes in bulky stage IB2 cervical cancer patients: a single institution's experience over 14 years.

Abstract:

AIM:The aim of this study was to assess various treatment options in stage IB2 cervical cancer patients. METHODS:Between January 1995 and May 2007, 63 patients with stage IB2 were treated by radical hysterectomy (n = 28), primary concurrent chemoradiation (CCRT, n = 16) or radiation therapy (RT, n = 19). Disease-free survival (DFS) and overall survival (OS) were compared between these treatment modalities. RESULTS:The 3-year DFS of the surgical approach group was 67.5% compared to 70.3% of the primary RT/CCRT group (p = 0.603). The 5-year OS of all patients was 75.9%. The 5-year OS of the surgical approach group was 81.6% compared to 76.2% of the primary RT/CCRT group (p = 0.578). Twelve (42.8%) of 28 surgically treated patients had high-risk pathologic factors. Out of 20 premenopausal patients who underwent the surgical approach, ovarian preservation was possible in 13 patients without adjuvant CCRT. Of these 13 patients, 7 patients did not experience disease recurrence and continued normal ovarian function. CONCLUSION:Both radical hysterectomy and primary RT/CCRT are effective treatment options in IB2 cervical cancer. In addition, the surgical approach can be considered for preserving ovarian function in premenopausal IB2 cervical cancer patients.

journal_name

Gynecol Obstet Invest

authors

Kim WY,Chang SJ,Chang KH,Yoo SC,Chun M,Ryu HS

doi

10.1159/000320722

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

19-23

issue

1

eissn

0378-7346

issn

1423-002X

pii

000320722

journal_volume

71

pub_type

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