Abstract:
:Human heparanase has been shown to function in tumor progression, metastatic spread, and tumor angiogenesis. The aim of the present study was to assess heparanase expression in endometrial cancer in correlation with neovascularization and clinicopathological factors. Forty endometrial cancers were obtained from previously untreated patients (median age 55.5, range 33-78 years). The expression of heparanase mRNA was evaluated using a semiquantitative reverse transcriptase-polymerase chain reaction. Tumor angiogenesis was assessed using microvessel counting. The Mann-Whitney U test, one-factor ANOVA test, and Spearman's test were used to determine the relationship between heparanase expression, microvessel density, and clinicopathological parameters. The expression of heparanase mRNA was detected in 20 of 40 (50%) endometrial cancers, and was significantly correlated with FIGO stage IIIc (p=0.0075), the presence of lymph-vascular space involvement (p=0.0041), lymph node metastasis (p=0.0049), and histological tumor grade (p=0.0030). Microvessel density was also associated with FIGO stage IIIc (p=0.027), the presence of lymph-vascular space involvement (p=0.001), lymph node metastasis (p=0.038), ovarian metastasis (p=0.030) and histological tumor grade (p=0.0030). Moreover, we found a strong positive correlation between heparanase expression and microvessel density (r2=0.475, p=0.0001). These results suggest that the expression of heparanase may influence different malignant behaviors in endometrial cancer.
journal_name
Gynecol Obstet Investjournal_title
Gynecologic and obstetric investigationauthors
Watanabe M,Aoki Y,Kase H,Tanaka Kdoi
10.1159/000072821keywords:
subject
Has Abstractpub_date
2003-01-01 00:00:00pages
77-82issue
2eissn
0378-7346issn
1423-002Xpii
72821journal_volume
56pub_type
杂志文章abstract::The HELLP syndrome is a severe complication of pregnancy. It usually occurs in the middle of the third trimester. In our case, however, a very early development is reported. ...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000293233
更新日期:1990-01-01 00:00:00
abstract:OBJECTIVE:To determine whether, in addition to treatment with antibiotics, it is necessary to remove the intrauterine device (IUD) to eliminate genital colonization by Actinomyces. METHODS:A randomized clinical trial was carried out. Patients were divided into two groups. The intervention group did not have their IUDs...
journal_title:Gynecologic and obstetric investigation
pub_type: 临床试验,杂志文章,随机对照试验
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abstract:OBJECTIVE:To compare embryo transfer (ET) technique based on catheter rotation during its withdrawal in cases with unexplained infertility in a prospective, randomized trial (NCT03097042). METHODS:Two hundred intracytoplasmic sperm injection (ICSI) patients undergoing ET with cleaving or blastocyst-stage fresh embryos...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章,随机对照试验
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journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000010119
更新日期:1999-01-01 00:00:00
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journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000356960
更新日期:2014-01-01 00:00:00
abstract::Our objective was to evaluate the efficacy and safety of labor induction in women with a breech presentation, and an unripe cervix. We conducted a retrospective, matched-paired study on patients with breech presentation and an unripe cervix (n = 23), who underwent induction of labor using extra-amniotic saline instill...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000010029
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journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000327938
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journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000098316
更新日期:2007-01-01 00:00:00
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journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000080020
更新日期:2004-01-01 00:00:00
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journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000291858
更新日期:1997-01-01 00:00:00
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journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000106489
更新日期:2007-01-01 00:00:00
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journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000074451
更新日期:2003-01-01 00:00:00
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journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000294838
更新日期:1992-01-01 00:00:00
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journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000293689
更新日期:1988-01-01 00:00:00
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journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000074815
更新日期:2003-01-01 00:00:00
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journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章,评审
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更新日期:2003-01-01 00:00:00
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journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000299404
更新日期:1983-01-01 00:00:00
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journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000293611
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journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000126494
更新日期:2008-01-01 00:00:00
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journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
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journal_title:Gynecologic and obstetric investigation
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journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000292710
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journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000458523
更新日期:2018-01-01 00:00:00
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journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000331652
更新日期:2012-01-01 00:00:00
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journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000298871
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journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000292284
更新日期:1996-01-01 00:00:00
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journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000292511
更新日期:1994-01-01 00:00:00
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journal_title:Gynecologic and obstetric investigation
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journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000299461
更新日期:1982-01-01 00:00:00